... into the etiology of disease-linked connexin mutants. However, the commonly used Xenopus oocytes, N2A, HeLa, and other model cells for recombinant expression of human connexins have different and significant limitations. Here we developed a human cell line (HEK293) with each of the endogenous connexins (Cx43...

... 2015 Degradation of Cx43 can occur in the proteasome, in the context of ERAD (endoplasmic-reticulum-associated protein degradation), or in the lysosome, as part of autophagy or endocytic pathways [ 7 , 8 ]. Additionally, we demonstrated that Nedd4 (neural-precursor-cell-expressed developmentally...