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Keywords: DNA damage
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Biochem J (2023) 480 (18): 1479–1483.
Published: 25 September 2023
...-fidelity mode of DNA damage tolerance (DDT), which involves TLS polymerases such as polη [ 10 ]. Polη contains 713 amino acids with the catalytic domains including ‘finger', ‘palm', ‘PAD' (also named ‘little finger') and ‘thumb' [ 10–13 ]. Unlike replicative DNA polymerases which can be blocked...
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Biochem J (2023) 480 (9): 649–664.
Published: 10 May 2023
... AMP and GMP, and our findings presented here will be valuable information for a wide range of biological and medical research including the drug development for various diseases. The integrity of the human genome is under constant attacks by both exogenous and endogenous DNA-damaging agents. One...
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Biochem J (2022) 479 (22): 2345–2349.
Published: 23 November 2022
...Elizabeth M. Black; Yoon Ki Joo; Lilian Kabeche Chk1 is a member of the DNA damage response pathway, whose loss leads to replication stress and genome instability. Because of its protective role against lethal levels of DNA replication stress, Chk1 has been studied as a valuable and intriguing...
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Biochem J (2022) 479 (13): 1429–1439.
Published: 04 July 2022
... assay. DNA damage is inhibited by growth media containing amino acids, which bind to extracellular Ru and prevent its entry into cells. We conclude that the cytotoxicity of Ru(II) is different from that of platinum, making it a promising development target for cancer therapeutics. Ruthenium exists...
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Biochem J (2021) 478 (12): 2359–2370.
Published: 23 June 2021
... 2021 27 5 2021 1 6 2021 1 6 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 base excision repair DNA damage DNA glycosylase oxidative stress Activation of macrophages and neutrophils during the inflammatory...
Includes: Supplementary data
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Biochem J (2021) 478 (7): 1399–1412.
Published: 16 April 2021
...Evgeniy S. Shilkin; Anastasia S. Gromova; Margarita P. Smal; Alena V. Makarova Y-family DNA polymerase iota (Pol ι) is involved in DNA damage response and tolerance. Mutations and altered expression level of POLI gene are linked to a higher incidence of cancer. We biochemically characterized five...
Includes: Supplementary data
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Biochem J (2020) 477 (24): 4797–4810.
Published: 24 December 2020
...Hunmin Jung; Michael A. Hawkins; Seongmin Lee The exocyclic amines of nucleobases can undergo deamination by various DNA damaging agents such as reactive oxygen species, nitric oxide, and water. The deamination of guanine and adenine generates the promutagenic xanthine and hypoxanthine...
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Biochem J (2019) 476 (21): 3401–3411.
Published: 15 November 2019
... with intrinsic disorder regions. HDM2 is a hub protein with a large interactome and with different cellular functions. It is best known for its regulation of the p53 tumour suppressor. Under normal cellular conditions, HDM2 ubiquitinates and degrades p53 by the 26S proteasome but after DNA damage, HDM2 switches...
Includes: Supplementary data
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Biochem J (2015) 465 (3): 413–421.
Published: 22 January 2015
... of Alzheimer's disease (AD) and AICD has important roles in the regulation of gene transcription (in complex with Fe65). It is therefore important to understand how Fe65 is regulated and how this contributes to the function and/or processing of APP. Studies have also implicated Fe65 in the cellular DNA damage...
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Biochem J (2012) 448 (1): 115–125.
Published: 18 October 2012
... translocations in lymphoid malignancies. chromosomal translocation double-strand break DNA damage leukaemia single-strand break V(D)J recombination 5′ end-labelling of oligomeric DNA was performed as described previously [ 26 ] using T4 polynucleotide kinase and [γ- 32 P]ATP at 37°C for 1 h...
Includes: Supplementary data
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Biochem J (2012) 443 (1): 213–222.
Published: 14 March 2012
... ] and induction of accelerated cell senescence [ 8 ]. Protein and DNA damage by MG is suppressed by Glo1 (glyoxalase 1) which catalyses the GSH-dependent conversion of MG into S - D -lactoylglutathione. Further metabolism of S - D -lactoylglutathione to D -lactate is catalysed by Glo2 which restores GSH...
Includes: Supplementary data
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Biochem J (2012) 441 (3): 813–821.
Published: 16 January 2012
...) and PLGA [poly(lactic-co-glycolic acid)]-PEO [poly(ethylene oxide)] polymeric NPs (150 nm). We evaluated their uptake by the cells, and their localization, generation of oxidative stress and DNA-damaging effects in exposed cells. We show that NPs are internalized by human brain-derived endothelial cells...
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Biochem J (2010) 428 (2): 147–161.
Published: 13 May 2010
... that chromosome segregation is not the only important function of cohesin in the maintenance of genome integrity. chromosome segregation cohesion DNA damage heterochromatin transcriptional insulation 1 These authors contributed equally to this work. 2 To whom correspondence should...
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Biochem J (2009) 424 (3): 431–438.
Published: 10 December 2009
.... Apoptosis was the predominant type of cell death, with mechanistic studies revealing that oxidative stress and DNA damage may have a part to play. For the first time, uptake of Ant 4 via the PTS was demonstrated both directly and indirectly in human cell lines. In addition, Ant 4 significantly reduced...
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Biochem J (2009) 423 (3): 363–374.
Published: 12 October 2009
... of HUVECs upon knockdown of Nox4. Surprisingly, mean telomere length was significantly reduced in Nox4-depleted cells. Nox4 depletion had no discernable influence on the activity of MAPKs and stress-activated kinases, but reduced the degree of oxidative DNA damage. These results suggest that Nox4 activity...
Includes: Supplementary data
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Biochem J (2009) 422 (3): 543–551.
Published: 27 August 2009
...Hanshao Liu; Hoi Chin Hew; Zheng-Guang Lu; Tomoko Yamaguchi; Yoshio Miki; Kiyotsugu Yoshida Transcriptional regulation of the p53 tumour suppressor gene plays an important role in the control of the expression of various target genes involved in the DNA damage response. However, the molecular basis...
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Biochem J (2008) 415 (2): 297–307.
Published: 25 September 2008
... protein 10] fusion generated by a t(12;16)(q13;p11) chromosomal translocation, Ser 42 in FUS–CHOP is not phosphorylated after DNA damage. These results identify FUS as a new target of the ATM-signalling pathway and strengthen the notion that FUS regulates genome stability. 1 To whom correspondence...
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Biochem J (2007) 406 (3): 437–444.
Published: 29 August 2007
... into the reaction mixture prior to the EMSA reaction. The dissociation constants for p53 and the oligonucleotides were determined using Scatchard plot analysis as described previously [ 24 ]. chromatin immunoprecipitation DNA damage p53 PC4 promoter transcription The tumour suppressor protein...
Includes: Supplementary data
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Biochem J (2006) 400 (3): 573–582.
Published: 28 November 2006
...Roni H. G. Wright; Edward S. Dornan; Mary M. Donaldson; Iain M. Morgan TopBP1 has eight BRCT [BRCA1 (breast-cancer susceptibility gene 1) C-terminus] domains and is involved in initiating DNA replication, and DNA damage checkpoint signalling and repair. Several BRCT-domain-containing proteins...
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Biochem J (2005) 388 (3): 813–818.
Published: 07 June 2005
...Ayako FURUKAWA; Yusuke HIRAKU; Shinji OIKAWA; Catherine LUXFORD; Michael J. DAVIES; Shosuke KAWANISHI In γ-irradiation, • OH is directly generated from water and causes DNA damage leading to carcinogenesis. Exposure of proteins to γ-irradiation, in the presence of oxygen, gives high yields...
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Biochem J (2005) 388 (2): 705–712.
Published: 24 May 2005
...Catriona A. L. CLARKE; Paul R. CLARKE Cell-cycle checkpoints induced by DNA damage or replication play critical roles in the maintenance of genomic integrity during cell proliferation. Biochemical analysis of checkpoint pathways has been greatly facilitated by the use of cell-free systems made from...
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Biochem J (2005) 388 (1): e1.
Published: 10 May 2005
...Benjamin N. WARDLEWORTH; Jessica A. DOWNS In response to DNA damage, cells initiate multiple repair mechanisms that all contribute to the survival of both the cell and the organism. These responses are numerous and variable, and can include cell cycle arrest, transcriptional activation of DNA...
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Biochem J (2001) 359 (1): 183–192.
Published: 24 September 2001
..., such as hypoxia or heat shock. Induction of genotoxic stress also results in a large reduction in global protein synthesis rates and therefore we investigated whether the c- myc IRES was active following DNA damage. As expected, in cells treated with either ethylmethane sulphonate or mitomycin C there was a large...
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Biochem J (2001) 356 (2): 509–513.
Published: 24 May 2001
... with dehydroascorbic acid, the vitamin present in the cells was all in its reduced form. It was found that, in cells that are otherwise ascorbate-deficient, an increase in their ascorbic acid content does not prevent, but rather enhances, the DNA-damaging and lethal responses mediated by exogenous ONOO...
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Biochem J (2001) 355 (2): 473–479.
Published: 06 April 2001
... (MTGSH cells). Cell survival following exposure to oxidative stress and chemical agents was higher in cells expressing the native MT gene than in cells where MT localization was disrupted, or in untransfected cells. Also, MTMT cells showed less DNA damage than MTGSH cells in response to either hydrogen...
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Biochem J (2000) 352 (1): 1–17.
Published: 07 November 2000
... and the experimental strategies that have been developed for the re- activation of the p53 pathway in cancers. Key words: cell-cycle checkpoint pathway, degradation, DNA damage, transcription. THE TRANSACTIVATION FUNCTION OF p53 PROTEIN The functional and regulatory domains of p53 Following the discovery of p53...
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Biochem J (1999) 344 (1): 125–134.
Published: 08 November 1999
... give rise to subsequent DNA damage; the latter includes both DNA-protein cross-links and formation of oxidized DNA bases. 1 To whom correspondence should be addressed (e-mail m.davies@hri.org.au). 14 6 1999 16 8 1999 10 9 1999 The Biochemical Society, London © 1999 1999...