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Keywords: DNA repair
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Biochem J (2024) 481 (14): 923–944.
Published: 10 July 2024
... reliant on DNA repair pathways that have evolved to deal with every type of genotoxic insult that threatens to compromise genome stability. Notably, inherited mutations in genes encoding proteins involved in these protective pathways trigger the onset of disease that is driven by chromosome instability...
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Biochem J (2020) 477 (16): 2935–2947.
Published: 19 August 2020
...Ryan J. Buckley; Kevin Kramm; Christopher D. O. Cooper; Dina Grohmann; Edward L. Bolt The DNA helicase L arge h elicase -r elated (Lhr) is present throughout archaea, including in the Asgard and Nanoarchaea, and has homologues in bacteria and eukaryotes. It is thought to function in DNA repair...
Includes: Supplementary data
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Biochem J (2017) 474 (11): 1837–1852.
Published: 16 May 2017
... of α-ketoglutarate (αKG)- and iron-dependent dioxygenases [ 17 ]. Its homologs are present in almost all organisms including humans [ 18 , 19 ]. A previous bioinformatic analysis of protein sequence databases identified 1943 AlkB sequences with eight new AlkB subfamilies [ 20 ]. AlkB-like DNA repair...
Includes: Supplementary data
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Biochem J (2016) 473 (9): 1237–1245.
Published: 26 April 2016
...Ning Tsao; Ya-Chi Yang; Yu-Jyun Deng; Zee-Fen Chang Cellular supply of dNTPs via RNR (ribonucleotide reductase) is crucial for DNA replication and repair. It has been shown that DNA-damage-site-specific recruitment of RNR is critical for DNA repair efficiency in quiescent cells. The catalytic...
Includes: Supplementary data
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Biochem J (2016) 473 (2): 123–133.
Published: 05 January 2016
... functionally characterized N-terminal domain of the protein. Although the impact of this mutation on the Mt OGT activity has not yet been proved in vivo , we previously demonstrated that a recombinant Mt OGT-R37L variant performs a suboptimal alkylated-DNA repair in vitro , suggesting a direct role for the Arg...
Includes: Supplementary data
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Biochem J (2015) 468 (2): 227–244.
Published: 22 May 2015
... signal in the presence of BSA. DNA repair flap endonuclease helicase RecQ replication telomere PAGE-purified oligonucleotides (Midland Certified Reagent Co.) used for preparation of DNA substrates were as described in [ 15 , 40 , 41 ]. Briefly, oligonucleotides were 5′ end-labelled...
Includes: Supplementary data
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Biochem J (2015) 466 (3): 613–624.
Published: 06 March 2015
... stages of BRCA1-mediated DNA repair by homologous recombination using chicken lymphoblastoid DT40 cells as a model system. We found that all of the mutations, regardless of how profound their destabilizing effects, retained some DNA repair activity and thereby partially rescued the chicken BRCA1 knockout...
Includes: Supplementary data
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Biochem J (2013) 456 (1): 89–98.
Published: 24 October 2013
... SIRT1 and TDG may mediate DNA repair, gene expression and FU (5-fluorouracil)-mediated cytotoxicity. 1 Present address: Department of Natural & Physical Sciences, Life Sciences Institute, Baltimore City Community College, MD 21201, U.S.A. 2 To whom correspondence should be addressed...
Includes: Supplementary data
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Biochem J (2013) 453 (1): 125–136.
Published: 13 June 2013
... of NKX3.1 on cell survival after DNA damage as topoisomerase knockdown blocked the effect of NKX3.1 on clonogenicity after DNA damage. Therefore NKX3.1 and topoisomerase I interact in vitro and in cells to affect the CPT sensitivity and DNA-repair functions of NKX3.1. HEK-293T cells were engineered...
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Biochem J (2012) 445 (3): 393–401.
Published: 13 July 2012
... Biochemical Society 2012 Arabidopsis DNA double-strand break DNA repair epigenetics recombination Protein samples were separated using 10% acrylamide/bisacrylamide (19:1) Tricine gels containing ethylene glycol (30%, v/v) according to [ 17 ] using the Protean II xi Cell electrophoresis...
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Biochem J (2012) 443 (1): 13–26.
Published: 14 March 2012
... phosphorylates a large number of downstream targets involved in checkpoint signalling, DNA repair and apoptosis, such as histone H2AX [ 71 ] and tumour protein p53 [ 72 ]. One important role of ATR is the phosphorylation and activation of the effector kinase CHK1 (checkpoint kinase 1) [ 73 , 74 ]. Efficient...
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Biochem J (2012) 442 (1): 77–84.
Published: 27 January 2012
...://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. damage inducible gene G (DinG) DNA repair helicase iron–sulfur nuclease xeroderma pigmentosum complementation group D (XPD...
Includes: Supplementary data
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Biochem J (2011) 440 (2): 293–300.
Published: 14 November 2011
... the hypothesis that hSuv3 may play a significant role in nuclear DNA metabolism as well. 1 To whom correspondence should be addressed (email [email protected] ). 6 7 2010 15 8 2011 17 8 2011 17 8 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 DNA repair...
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Biochem J (2011) 436 (3): 559–566.
Published: 27 May 2011
[email protected] ). 9 11 2010 15 3 2011 4 4 2011 4 4 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 DNA repair DNA topoisomerase I proteasome tyrosyl-DNA phosphodiesterase (TDP) TDP1 was discovered by virtue of its ability to hydrolyse a tyrosyl...
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Biochem J (2011) 436 (3): 671–679.
Published: 27 May 2011
... DNA repair poly(ADP-ribose) polymerase (PARP) poly(ADP-ribose) polymerase activity poly(ADP-ribose) polymerase expression radiotherapy Patients vary in their toxic and therapeutic response to treatment owing to several different factors, and pharmacogenetics may be used to predict toxicity...
Includes: Supplementary data
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Biochem J (2010) 430 (1): 119–128.
Published: 28 July 2010
... intermediates formed during DNA replication and gene expression. DNA repair DNA replication genome stability G-quadruplex DNA (G4 DNA) Pif1 helicase protein–DNA interactions DNA can adopt structures other than the canonical B-form duplex stabilized by Watson–Crick base pairing. Structures...
Includes: Supplementary data
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Biochem J (2010) 426 (3): 365–371.
Published: 24 February 2010
...Catherine Chailleux; Sandrine Tyteca; Christophe Papin; François Boudsocq; Nadine Puget; Céline Courilleau; Mikhaïl Grigoriev; Yvan Canitrot; Didier Trouche Chromatin modifications and chromatin-modifying enzymes are believed to play a major role in the process of DNA repair. The histone acetyl...
Includes: Supplementary data
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Biochem J (2009) 423 (2): 265–277.
Published: 25 September 2009
... Society 2009 DNA repair endonuclease MutL NgoL Neisseria gonorrhoeae All reagents used were of analytical or ultra-pure grade. [γ- 32 P]ATP (3500 Ci/mmol) was purchased from Bhabha Atomic Research Centre. MgCl 2 , MnCl 2 , CaCl 2 , BSA, Amp (ampicillin), Hepes, imidazole and Coomassie...
Includes: Supplementary data
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Biochem J (2007) 401 (1): 1–11.
Published: 11 December 2006
... The Biochemical Society, London 2007 antioxidant cancer DNA repair nitric oxide reactive oxygen species In 1996, I co-authored in the Biochemical Journal an article speculating on the role of oxygen radicals and other ‘reactive species’ (RS; defined in the legend to Figure 1 ) in cancer [ 1...
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Biochem J (2006) 398 (3): 319–337.
Published: 29 August 2006
... with an emphasis on how this distinct class of enzymes functions in chromosomal stability maintenance and prevention of human disease and cancer. 27 3 2006 17 7 2006 17 7 2006 The Biochemical Society, London 2006 aging cancer DNA repair genomic instability helicase RecQ...
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Biochem J (2006) 393 (1): 303–309.
Published: 12 December 2005
...Lyne Jossé; Margaret E. Harley; Isabel M. S. Pires; David A. Hughes Human DSS1 associates with BRCA2, a tumour suppressor protein required for efficient recombinational DNA repair, but the biochemical function of DSS1 is not known. Orthologues of DSS1 are found in organisms such as budding yeast...
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Biochem J (2005) 387 (3): 859–863.
Published: 26 April 2005
... ). 30 9 2004 1 12 2004 10 12 2004 10 12 2004 The Biochemical Society, London 2005 DNA repair DNA replication proliferating cell nuclear antigen (PCNA) Sulfolobus uracil uracil DNA glycosylase (UDG) PCNA (proliferating cell nuclear antigen) is a toroidal...
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Biochem J (2004) 379 (1): 71–78.
Published: 01 April 2004
.... The molecular mechanism of repairing the ICL damage has not been well established. We have studied the role of XPF (xeroderma pigmentosum group F) protein in psoralen-induced ICL-mediated DNA repair and mutagenesis. The results obtained from our mutagenesis studies revealed a very similar mutation frequency...
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Biochem J (2003) 375 (2): 449–455.
Published: 15 October 2003
...Sreenivas KANUGULA; Anthony E. PEGG AGT ( O 6 -alkylguanine DNA alkyltransferase) is an important DNA-repair protein that protects cells from killing and mutagenesis by alkylating agents. The AGT genes from two extremely thermophilic organisms, the bacterium Aquifex aeolicus and the archaeon...
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Biochem J (2003) 374 (3): 577–606.
Published: 15 September 2003
... against replication fork demise, either through prevention of fork breakdown or restoration of productive DNA synthesis. Key words: cancer predisposition, chromosomal instability, DNA repair, progeroid syndrome, RecQ helicase, topoisomerase. INTRODUCTION Helicases are enzymes that use the energy derived...
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Biochem J (2000) 347 (2): 363–368.
Published: 10 April 2000
... with the known properties of the reaction in ŠiŠo and suggest that the new cell-free system will be suitable for purifying enzymes involved in homologous recombination. Key words: DNA repair, heteroduplex DNA, recombination. in hDNA formation. These biochemical studies argue that proteins encoded by genes...
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Biochem J (2000) 347 (2): 527–534.
Published: 10 April 2000
...Meng XU-WELLIVER; Sreenivas KANUGULA; Natalia A. LOKTIONOVA; Tina M. CRONE; Anthony E. PEGG The role of lysine 165 in the activity of the DNA repair protein, O 6 -alkylguanine-DNA alkyltransferase (AGT), and the ability of AGT to react with the pseudosubstrate inhibitor, O 6 -benzylguanine (BG...
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Biochem J (1999) 342 (2): 249–268.
Published: 24 August 1999
... supported by the identification of direct protein-protein interactions involving poly(ADP-ribose) polymerase (113 kDa PARP), an enzyme catalysing the formation of poly(ADP-ribose), and key effectors of DNA repair, replication and transcription reactions. The presence of PARP in these multiprotein complexes...
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Biochem J (1999) 337 (2): 311–317.
Published: 08 January 1999
... the ssDNA and stimulates pol a and pol d [14 16], even though the latter may not be essential for DNA replication [17]. RPA also functions in damaged DNA repair [18 20] and homologous recombination [21]. In nucleotide excision repair (NER), RPA forms a complex with Xeroderma pigmentosum group...