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E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease

Anoop S. Chauhan, Satpal S. Jhujh, Grant S. Stewart

Biochem J (2024) 481 (14): 923–944.

https://doi.org/10.1042/BCJ20240124

Published: 10 July 2024

... reliant on DNA repair pathways that have evolved to deal with every type of genotoxic insult that threatens to compromise genome stability. Notably, inherited mutations in genes encoding proteins involved in these protective pathways trigger the onset of disease that is driven by chromosome instability...

View articletitled, E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease

Articles

Mechanistic insights into Lhr helicase function in DNA repair

Ryan J. Buckley, Kevin Kramm, Christopher D. O. Cooper, Dina Grohmann, Edward L. Bolt

Biochem J (2020) 477 (16): 2935–2947.

https://doi.org/10.1042/BCJ20200379

Published: 19 August 2020

...Ryan J. Buckley; Kevin Kramm; Christopher D. O. Cooper; Dina Grohmann; Edward L. Bolt The DNA helicase L arge h elicase -r elated (Lhr) is present throughout archaea, including in the Asgard and Nanoarchaea, and has homologues in bacteria and eukaryotes. It is thought to function in DNA repair...

View articletitled, Mechanistic insights into Lhr helicase function in DNA repair

Includes: Supplementary data

Articles

1,N 6 -α-hydroxypropanoadenine, the acrolein adduct to adenine, is a substrate for AlkB dioxygenase

Małgorzata Dylewska, Jarosław T. Kuśmierek, Tomasz Pilżys, Jarosław Poznański, Agnieszka M. Maciejewska

Biochem J (2017) 474 (11): 1837–1852.

https://doi.org/10.1042/BCJ20161008

Published: 16 May 2017

... of α-ketoglutarate (αKG)- and iron-dependent dioxygenases [ 17 ]. Its homologs are present in almost all organisms including humans [ 18 , 19 ]. A previous bioinformatic analysis of protein sequence databases identified 1943 AlkB sequences with eight new AlkB subfamilies [ 20 ]. AlkB-like DNA repair...

View articletitled, 1,N 6 -α-hydroxypropanoadenine, the acrolein adduct to adenine, is a substrate for AlkB dioxygenase

Includes: Supplementary data

Articles

The direct interaction of NME3 with Tip60 in DNA repair

Ning Tsao, Ya-Chi Yang, Yu-Jyun Deng, Zee-Fen Chang

Biochem J (2016) 473 (9): 1237–1245.

https://doi.org/10.1042/BCJ20160122

Published: 26 April 2016

...Ning Tsao; Ya-Chi Yang; Yu-Jyun Deng; Zee-Fen Chang Cellular supply of dNTPs via RNR (ribonucleotide reductase) is crucial for DNA replication and repair. It has been shown that DNA-damage-site-specific recruitment of RNR is critical for DNA repair efficiency in quiescent cells. The catalytic...

View articletitled, The direct interaction of NME3 with Tip60 in DNA repair

Includes: Supplementary data

Articles

Crystal structure of Mycobacterium tuberculosis O 6 -methylguanine-DNA methyltransferase protein clusters assembled on to damaged DNA

Riccardo Miggiano, Giuseppe Perugino, Maria Ciaramella, Mario Serpe, Dominik Rejman, Ondřej Páv, Radek Pohl, Silvia Garavaglia, Samarpita Lahiri, Menico Rizzi, Franca Rossi

Biochem J (2016) 473 (2): 123–133.

https://doi.org/10.1042/BJ20150833

Published: 05 January 2016

... functionally characterized N-terminal domain of the protein. Although the impact of this mutation on the Mt OGT activity has not yet been proved in vivo , we previously demonstrated that a recombinant Mt OGT-R37L variant performs a suboptimal alkylated-DNA repair in vitro , suggesting a direct role for the Arg...

View articletitled, Crystal structure of Mycobacterium tuberculosis O 6 -methylguanine-DNA methyltransferase protein clusters assembled on to damaged DNA

Includes: Supplementary data

Articles

RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin

Furqan Sami, Xing Lu, Swetha Parvathaneni, Rabindra Roy, Ronald K. Gary, Sudha Sharma

Biochem J (2015) 468 (2): 227–244.

https://doi.org/10.1042/BJ20141021

Published: 22 May 2015

... signal in the presence of BSA. DNA repair flap endonuclease helicase RecQ replication telomere PAGE-purified oligonucleotides (Midland Certified Reagent Co.) used for preparation of DNA substrates were as described in [ 15 , 40 , 41 ]. Briefly, oligonucleotides were 5′ end-labelled...

View articletitled, RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin

Includes: Supplementary data

Articles

Protein stability versus function: effects of destabilizing missense mutations on BRCA1 DNA repair activity

David C.A. Gaboriau, Pamela J.E. Rowling, Ciaran G. Morrison, Laura S. Itzhaki

Biochem J (2015) 466 (3): 613–624.

https://doi.org/10.1042/BJ20141077

Published: 06 March 2015

... stages of BRCA1-mediated DNA repair by homologous recombination using chicken lymphoblastoid DT40 cells as a model system. We found that all of the mutations, regardless of how profound their destabilizing effects, retained some DNA repair activity and thereby partially rescued the chicken BRCA1 knockout...

View articletitled, Protein stability versus function: effects of destabilizing missense mutations on BRCA1 DNA repair activity

Includes: Supplementary data

Articles

Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase

Amrita Madabushi, Bor-Jang Hwang, Jin Jin, A-Lien Lu

Biochem J (2013) 456 (1): 89–98.

https://doi.org/10.1042/BJ20130670

Published: 24 October 2013

... SIRT1 and TDG may mediate DNA repair, gene expression and FU (5-fluorouracil)-mediated cytotoxicity. 1 Present address: Department of Natural & Physical Sciences, Life Sciences Institute, Baltimore City Community College, MD 21201, U.S.A. 2 To whom correspondence should be addressed...

View articletitled, Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase

Includes: Supplementary data

Articles

Structural and functional interactions of the prostate cancer suppressor protein NKX3.1 with topoisomerase I

Liang-Nian Song, Cai Bowen, Edward P. Gelmann

Biochem J (2013) 453 (1): 125–136.

https://doi.org/10.1042/BJ20130012

Published: 13 June 2013

... of NKX3.1 on cell survival after DNA damage as topoisomerase knockdown blocked the effect of NKX3.1 on clonogenicity after DNA damage. Therefore NKX3.1 and topoisomerase I interact in vitro and in cells to affect the CPT sensitivity and DNA-repair functions of NKX3.1. HEK-293T cells were engineered...

View articletitled, Structural and functional interactions of the prostate cancer suppressor protein NKX3.1 with topoisomerase I

Articles

Dynamics of plant histone modifications in response to DNA damage

Georgina E. Drury, Adam A. Dowle, David A. Ashford, Wanda M. Waterworth, Jerry Thomas, Christopher E. West

Biochem J (2012) 445 (3): 393–401.

https://doi.org/10.1042/BJ20111956

Published: 13 July 2012

... Biochemical Society 2012 Arabidopsis DNA double-strand break DNA repair epigenetics recombination Protein samples were separated using 10% acrylamide/bisacrylamide (19:1) Tricine gels containing ethylene glycol (30%, v/v) according to [ 17 ] using the Protean II xi Cell electrophoresis...

View articletitled, Dynamics of plant histone modifications in response to DNA damage

Articles

Replication fork dynamics and the DNA damage response

Rebecca M. Jones, Eva Petermann

Biochem J (2012) 443 (1): 13–26.

https://doi.org/10.1042/BJ20112100

Published: 14 March 2012

... phosphorylates a large number of downstream targets involved in checkpoint signalling, DNA repair and apoptosis, such as histone H2AX [ 71 ] and tumour protein p53 [ 72 ]. One important role of ATR is the phosphorylation and activation of the effector kinase CHK1 (checkpoint kinase 1) [ 73 , 74 ]. Efficient...

View articletitled, Replication fork dynamics and the DNA damage response

Articles

Staphylococcus aureus DinG, a helicase that has evolved into a nuclease

Anne-Marie McRobbie, Bjoern Meyer, Christophe Rouillon, Biljana Petrovic-Stojanovska, Huanting Liu, Malcolm F. White

Biochem J (2012) 442 (1): 77–84.

https://doi.org/10.1042/BJ20111903

Published: 27 January 2012

...://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. damage inducible gene G (DinG) DNA repair helicase iron–sulfur nuclease xeroderma pigmentosum complementation group D (XPD...

View articletitled, Staphylococcus aureus DinG, a helicase that has evolved into a nuclease

Includes: Supplementary data

Articles

The human Suv3 helicase interacts with replication protein A and flap endonuclease 1 in the nucleus

Susanne T. Venø, Tomasz Kulikowicz, Cezar Pestana, Piotr P. Stepien, Tinna Stevnsner, Vilhelm A. Bohr

Biochem J (2011) 440 (2): 293–300.

https://doi.org/10.1042/BJ20100991

Published: 14 November 2011

... the hypothesis that hSuv3 may play a significant role in nuclear DNA metabolism as well. 1 To whom correspondence should be addressed (email [email protected] ). 6 7 2010 15 8 2011 17 8 2011 17 8 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 DNA repair...

View articletitled, The human Suv3 helicase interacts with replication protein A and flap endonuclease 1 in the nucleus

Articles

Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1

Heidrun Interthal, James J. Champoux

Biochem J (2011) 436 (3): 559–566.

https://doi.org/10.1042/BJ20101841

Published: 27 May 2011

[email protected] ). 9 11 2010 15 3 2011 4 4 2011 4 4 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 DNA repair DNA topoisomerase I proteasome tyrosyl-DNA phosphodiesterase (TDP) TDP1 was discovered by virtue of its ability to hydrolyse a tyrosyl...

View articletitled, Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1

Articles

Poly(ADP-ribose) polymerase-1 (PARP-1) pharmacogenetics, activity and expression analysis in cancer patients and healthy volunteers

Tomasz Zaremba, Huw D. Thomas, Michael Cole, Sally A. Coulthard, Elizabeth R. Plummer, Nicola J. Curtin

Biochem J (2011) 436 (3): 671–679.

https://doi.org/10.1042/BJ20101723

Published: 27 May 2011

... DNA repair poly(ADP-ribose) polymerase (PARP) poly(ADP-ribose) polymerase activity poly(ADP-ribose) polymerase expression radiotherapy Patients vary in their toxic and therapeutic response to treatment owing to several different factors, and pharmacogenetics may be used to predict toxicity...

View articletitled, Poly(ADP-ribose) polymerase-1 (PARP-1) pharmacogenetics, activity and expression analysis in cancer patients and healthy volunteers

Includes: Supplementary data

Articles

Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity

Cyril M. Sanders

Biochem J (2010) 430 (1): 119–128.

https://doi.org/10.1042/BJ20100612

Published: 28 July 2010

... intermediates formed during DNA replication and gene expression. DNA repair DNA replication genome stability G-quadruplex DNA (G4 DNA) Pif1 helicase protein–DNA interactions DNA can adopt structures other than the canonical B-form duplex stabilized by Watson–Crick base pairing. Structures...

View articletitled, Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity

Includes: Supplementary data

Articles

Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex

Catherine Chailleux, Sandrine Tyteca, Christophe Papin, François Boudsocq, Nadine Puget, Céline Courilleau, Mikhaïl Grigoriev, Yvan Canitrot, Didier Trouche

Biochem J (2010) 426 (3): 365–371.

https://doi.org/10.1042/BJ20091329

Published: 24 February 2010

...Catherine Chailleux; Sandrine Tyteca; Christophe Papin; François Boudsocq; Nadine Puget; Céline Courilleau; Mikhaïl Grigoriev; Yvan Canitrot; Didier Trouche Chromatin modifications and chromatin-modifying enzymes are believed to play a major role in the process of DNA repair. The histone acetyl...

View articletitled, Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex

Includes: Supplementary data

Articles

The C-terminal domain is sufficient for endonuclease activity of Neisseria gonorrhoeae MutL

Viswanadham Duppatla, Chiranjeevi Bodda, Claus Urbanke, Peter Friedhoff, Desirazu N. Rao

Biochem J (2009) 423 (2): 265–277.

https://doi.org/10.1042/BJ20090626

Published: 25 September 2009

... Society 2009 DNA repair endonuclease MutL NgoL Neisseria gonorrhoeae All reagents used were of analytical or ultra-pure grade. [γ- 32 P]ATP (3500 Ci/mmol) was purchased from Bhabha Atomic Research Centre. MgCl 2 , MnCl 2 , CaCl 2 , BSA, Amp (ampicillin), Hepes, imidazole and Coomassie...

View articletitled, The C-terminal domain is sufficient for endonuclease activity of Neisseria gonorrhoeae MutL

Includes: Supplementary data

Articles

Competition between NarL-dependent activation and Fis-dependent repression controls expression from the Escherichia coli yeaR and ogt promoters

Derrick J. P. Squire, Meng Xu, Jeffrey A. Cole, Stephen J. W. Busby, Douglas F. Browning

Biochem J (2009) 420 (2): 249–257.

https://doi.org/10.1042/BJ20090183

Published: 13 May 2009

... and, hence, this is the first report of expression of a DNA repair function being controlled by nitrate ions. DNA repair Fis NarL nitrate promoter reactive nitrogen species 1 These authors have contributed equally to this work. 2 To whom correspondence should be addressed (email...

View articletitled, Competition between NarL-dependent activation and Fis-dependent repression controls expression from the Escherichia coli yeaR and ogt promoters

Articles

Characterization of the interaction between the human DNA topoisomerase IIβ-binding protein 1 (TopBP1) and the cell division cycle 45 (Cdc45) protein

Uta Schmidt, Yvonne Wollmann, Claudia Franke, Frank Grosse, Hans-Peter Saluz, Frank Hänel

Biochem J (2008) 409 (1): 169–177.

https://doi.org/10.1042/BJ20070872

Published: 11 December 2007

... organisms. It is required for the initiation of DNA replication and for DNA repair and DNA damage signalling. Experiments with fission yeast and Xenopus revealed that the TopBP1 homologues of these organisms are required for chromatin loading of the replication protein Cdc45 (cell division cycle 45...

View articletitled, Characterization of the interaction between the human DNA topoisomerase IIβ-binding protein 1 (TopBP1) and the cell division cycle 45 (Cdc45) protein

Articles

Oxidative stress and cancer: have we moved forward?

Barry Halliwell

Biochem J (2007) 401 (1): 1–11.

https://doi.org/10.1042/BJ20061131

Published: 11 December 2006

... The Biochemical Society, London 2007 antioxidant cancer DNA repair nitric oxide reactive oxygen species In 1996, I co-authored in the Biochemical Journal an article speculating on the role of oxygen radicals and other ‘reactive species’ (RS; defined in the legend to Figure 1 ) in cancer [ 1...

View articletitled, Oxidative stress and cancer: have we moved forward?

Articles

Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability

Sudha Sharma, Kevin M. Doherty, Robert M. Brosh, Jr

Biochem J (2006) 398 (3): 319–337.

https://doi.org/10.1042/BJ20060450

Published: 29 August 2006

... with an emphasis on how this distinct class of enzymes functions in chromosomal stability maintenance and prevention of human disease and cancer. 27 3 2006 17 7 2006 17 7 2006 The Biochemical Society, London 2006 aging cancer DNA repair genomic instability helicase RecQ...

View articletitled, Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability

Articles

Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis

Lyne Jossé, Margaret E. Harley, Isabel M. S. Pires, David A. Hughes

Biochem J (2006) 393 (1): 303–309.

https://doi.org/10.1042/BJ20051238

Published: 12 December 2005

...Lyne Jossé; Margaret E. Harley; Isabel M. S. Pires; David A. Hughes Human DSS1 associates with BRCA2, a tumour suppressor protein required for efficient recombinational DNA repair, but the biochemical function of DSS1 is not known. Orthologues of DSS1 are found in organisms such as budding yeast...

View articletitled, Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis

Articles

Characterization of an archaeal family 4 uracil DNA glycosylase and its interaction with PCNA and chromatin proteins

Isabelle DIONNE, Stephen D. BELL

Biochem J (2005) 387 (3): 859–863.

https://doi.org/10.1042/BJ20041661

Published: 26 April 2005

... ). 30 9 2004 1 12 2004 10 12 2004 10 12 2004 The Biochemical Society, London 2005 DNA repair DNA replication proliferating cell nuclear antigen (PCNA) Sulfolobus uracil uracil DNA glycosylase (UDG) PCNA (proliferating cell nuclear antigen) is a toroidal...

View articletitled, Characterization of an archaeal family 4 uracil DNA glycosylase and its interaction with PCNA and chromatin proteins

Articles

Defining the function of xeroderma pigmentosum group F protein in psoralen interstrand cross-link-mediated DNA repair and mutagenesis

Zhiwen CHEN, Xiaoxin Susan XU, Jason HARRISON, Gan WANG

Biochem J (2004) 379 (1): 71–78.

https://doi.org/10.1042/bj20031143

Published: 01 April 2004

.... The molecular mechanism of repairing the ICL damage has not been well established. We have studied the role of XPF (xeroderma pigmentosum group F) protein in psoralen-induced ICL-mediated DNA repair and mutagenesis. The results obtained from our mutagenesis studies revealed a very similar mutation frequency...

View articletitled, Defining the function of xeroderma pigmentosum group F protein in psoralen interstrand cross-link-mediated DNA repair and mutagenesis

Articles

Alkylation damage repair protein O6-alkylguanine-DNA alkyltransferase from the hyperthermophiles Aquifex aeolicus and Archaeoglobus fulgidus

Sreenivas KANUGULA, Anthony E. PEGG

Biochem J (2003) 375 (2): 449–455.

https://doi.org/10.1042/bj20030809

Published: 15 October 2003

...Sreenivas KANUGULA; Anthony E. PEGG AGT ( O 6 -alkylguanine DNA alkyltransferase) is an important DNA-repair protein that protects cells from killing and mutagenesis by alkylating agents. The AGT genes from two extremely thermophilic organisms, the bacterium Aquifex aeolicus and the archaeon...

View articletitled, Alkylation damage repair protein O6-alkylguanine-DNA alkyltransferase from the hyperthermophiles Aquifex aeolicus and Archaeoglobus fulgidus

Articles

RecQ helicases: suppressors of tumorigenesis and premature aging

Csanád Z. BACHRATI, Ian D. HICKSON

Biochem J (2003) 374 (3): 577–606.

https://doi.org/10.1042/bj20030491

Published: 15 September 2003

... against replication fork demise, either through prevention of fork breakdown or restoration of productive DNA synthesis. Key words: cancer predisposition, chromosomal instability, DNA repair, progeroid syndrome, RecQ helicase, topoisomerase. INTRODUCTION Helicases are enzymes that use the energy derived...

View articletitled, RecQ helicases: suppressors of tumorigenesis and premature aging

Articles

Mutagenesis of the HMGB (high-mobility group B) protein Cmb1 (cytosine-mismatch binding 1) of Schizosaccharomyces pombe: effects on recognition of DNA mismatches and damage

Christophe KUNZ, Karin ZURBRIGGEN, Oliver FLECK

Biochem J (2003) 372 (2): 651–660.

https://doi.org/10.1042/bj20021506

Published: 01 June 2003

... 2003 cisplatin DNA repair high-mobility group mis-match mutation avoidance Abbreviations used: cisplatin, cis -diammine-dichloroplatinum(II) ( cis -denotes a cisplatin adduct); Cmb, cytosine-mismatch binding; Cmb1Δ41 (etc.), Cmb1 from which the 41 N-terminal amino acids have been...

View articletitled, Mutagenesis of the HMGB (high-mobility group B) protein Cmb1 (cytosine-mismatch binding 1) of Schizosaccharomyces pombe: effects on recognition of DNA mismatches and damage

Articles

An open reading frame in intron seven of the sea urchin DNA-methyltransferase gene codes for a functional AP1 endonuclease

Anna Valentina CIOFFI, Diana FERRARA, Maria Vittoria CUBELLIS, Francesco ANIELLO, Marcella CORRADO, Francesca LIGUORI, Alessandro AMOROSO, Laura FUCCI, Margherita BRANNO

Biochem J (2002) 365 (3): 833–840.

https://doi.org/10.1042/bj20011857

Published: 01 August 2002

... for a functional AP endonuclease designated SuAP1. 1 These authors contributed equally to this work. 2 To whom correspondence should be addressed (e-mail [email protected] ). 19 12 2001 22 3 2002 15 4 2002 The Biochemical Society, London ©2002 2002 development DNA repair...

View articletitled, An open reading frame in intron seven of the sea urchin DNA-methyltransferase gene codes for a functional AP1 endonuclease

Articles

Phosphorylation of methylated-DNA–protein-cysteine S-methyltransferase at serine-204 significantly increases its resistance to proteolytic digestion

In Kyoung LIM, Tae Jun PARK, Woon Ki PAIK

Biochem J (2000) 352 (3): 801–808.

https://doi.org/10.1042/bj3520801

Published: 08 December 2000

... © 2000 2000 endopeptidase Glu-C DNA repair hepatocarcinogenesis rat Biochem. J. (2000) 352, 801 808 (Printed in Great Britain) 801 Phosphorylation of methylated-DNA protein-cysteine S-methyltransferase at serine-204 significantly increases its resistance to proteolytic digestion...

View articletitled, Phosphorylation of methylated-DNA–protein-cysteine S-methyltransferase at serine-204 significantly increases its resistance to proteolytic digestion

Articles

Yeast cell-free system that catalyses joint-molecule formation in a Rad51p- and Rad52p-dependent fashion

Vijayalakshmi NAGARAJ, David NORRIS

Biochem J (2000) 347 (2): 363–368.

https://doi.org/10.1042/bj3470363

Published: 10 April 2000

... with the known properties of the reaction in io and suggest that the new cell-free system will be suitable for purifying enzymes involved in homologous recombination. Key words: DNA repair, heteroduplex DNA, recombination. in hDNA formation. These biochemical studies argue that proteins encoded by genes...

View articletitled, Yeast cell-free system that catalyses joint-molecule formation in a Rad51p- and Rad52p-dependent fashion

Articles

Conserved residue lysine165 is essential for the ability of O6-alkylguanine–DNA alkyltransferase to react with O6-benzylguanine

Meng XU-WELLIVER, Sreenivas KANUGULA, Natalia A. LOKTIONOVA, Tina M. CRONE, Anthony E. PEGG

Biochem J (2000) 347 (2): 527–534.

https://doi.org/10.1042/bj3470527

Published: 10 April 2000

...Meng XU-WELLIVER; Sreenivas KANUGULA; Natalia A. LOKTIONOVA; Tina M. CRONE; Anthony E. PEGG The role of lysine 165 in the activity of the DNA repair protein, O 6 -alkylguanine-DNA alkyltransferase (AGT), and the ability of AGT to react with the pseudosubstrate inhibitor, O 6 -benzylguanine (BG...

View articletitled, Conserved residue lysine165 is essential for the ability of O6-alkylguanine–DNA alkyltransferase to react with O6-benzylguanine

Articles

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

Damien d'AMOURS, Serge DESNOYERS, Icy d'SILVA, Guy G. POIRIER

Biochem J (1999) 342 (2): 249–268.

https://doi.org/10.1042/bj3420249

Published: 24 August 1999

... supported by the identification of direct protein-protein interactions involving poly(ADP-ribose) polymerase (113 kDa PARP), an enzyme catalysing the formation of poly(ADP-ribose), and key effectors of DNA repair, replication and transcription reactions. The presence of PARP in these multiprotein complexes...

View articletitled, Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

Articles

In vitro analysis of the zinc-finger motif in human replication protein A

Jiaowang DONG, Jang-Su PARK, Suk-Hee LEE

Biochem J (1999) 337 (2): 311–317.

https://doi.org/10.1042/bj3370311

Published: 08 January 1999

... the ssDNA and stimulates pol a and pol d [14 16], even though the latter may not be essential for DNA replication [17]. RPA also functions in damaged DNA repair [18 20] and homologous recombination [21]. In nucleotide excision repair (NER), RPA forms a complex with Xeroderma pigmentosum group...

View articletitled, In vitro analysis of the zinc-finger motif in human replication protein A

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