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Keywords: DNA repair
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Articles
Biochem J (2020) 477 (16): 2935–2947.
Published: 19 August 2020
...Ryan J. Buckley; Kevin Kramm; Christopher D. O. Cooper; Dina Grohmann; Edward L. Bolt The DNA helicase L arge h elicase -r elated (Lhr) is present throughout archaea, including in the Asgard and Nanoarchaea, and has homologues in bacteria and eukaryotes. It is thought to function in DNA repair but...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (11): 1837–1852.
Published: 16 May 2017
... Poznański ( jarek@ibb.waw.pl ) 15 11 2016 7 4 2017 13 4 2017 13 4 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 acrolein AlkB dioxygenase DNA repair mutagenesis substrate binding Temperature...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (9): 1237–1245.
Published: 26 April 2016
...Ning Tsao; Ya-Chi Yang; Yu-Jyun Deng; Zee-Fen Chang Cellular supply of dNTPs via RNR (ribonucleotide reductase) is crucial for DNA replication and repair. It has been shown that DNA-damage-site-specific recruitment of RNR is critical for DNA repair efficiency in quiescent cells. The catalytic...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (2): 123–133.
Published: 05 January 2016
... functionally characterized N-terminal domain of the protein. Although the impact of this mutation on the Mt OGT activity has not yet been proved in vivo , we previously demonstrated that a recombinant Mt OGT-R37L variant performs a suboptimal alkylated-DNA repair in vitro , suggesting a direct role for the Arg...
Includes: Supplementary data
Articles
Biochem J (2015) 468 (2): 227–244.
Published: 22 May 2015
... (Qiagen, SI03650325). Cells were reverse-transfected with siRNA (20 nM) using Lipofectamine RNAiMAX (Invitrogen) as instructed by the manufacturer. DNA repair flap endonuclease helicase RecQ replication telomere The RecQ helicase family is a group of highly conserved DNA-unwinding...
Includes: Supplementary data
Articles
Biochem J (2015) 466 (3): 613–624.
Published: 06 March 2015
... stages of BRCA1-mediated DNA repair by homologous recombination using chicken lymphoblastoid DT40 cells as a model system. We found that all of the mutations, regardless of how profound their destabilizing effects, retained some DNA repair activity and thereby partially rescued the chicken BRCA1 knockout...
Includes: Supplementary data
Articles
Biochem J (2013) 456 (1): 89–98.
Published: 24 October 2013
... SIRT1 and TDG may mediate DNA repair, gene expression and FU (5-fluorouracil)-mediated cytotoxicity. 15 5 2013 12 8 2013 16 8 2013 16 8 2013 1 Present address: Department of Natural & Physical Sciences, Life Sciences Institute, Baltimore City Community College, MD...
Includes: Supplementary data
Articles
Biochem J (2013) 453 (1): 125–136.
Published: 13 June 2013
... effect of NKX3.1 on cell survival after DNA damage as topoisomerase knockdown blocked the effect of NKX3.1 on clonogenicity after DNA damage. Therefore NKX3.1 and topoisomerase I interact in vitro and in cells to affect the CPT sensitivity and DNA-repair functions of NKX3.1. 1 To whom...
Articles
Biochem J (2012) 445 (3): 393–401.
Published: 13 July 2012
..., displaying dynamic responses to changes in the environment [ 4 ]. Chromatin remodelling activities have been shown to be important in both the signalling and repair of DSBs in mammalian and yeast systems [ 5 ]. However, our understanding of chromatin modifications and their importance in plant DNA repair...
Articles
Biochem J (2012) 443 (1): 13–26.
Published: 14 March 2012
... separation during mitosis. 1 To whom correspondence should be addressed (email e.petermann@bham.ac.uk ). 30 11 2011 10 1 2012 11 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cell cycle checkpoint DNA repair DNA helicase homologous...
Articles
Biochem J (2012) 442 (1): 77–84.
Published: 27 January 2012
... properly cited. damage inducible gene G (DinG) DNA repair helicase iron–sulfur nuclease xeroderma pigmentosum complementation group D (XPD) In contrast with the situation in E. coli , many Gram-positive bacterial DinG sequences lack the cysteine residues essential for the FeS cluster...
Includes: Supplementary data
Articles
Biochem J (2011) 440 (2): 293–300.
Published: 14 November 2011
... to homologous recombination and DNA repair [ 25 ]. FEN1 (flap endonuclease 1) is another well-documented partner of the RecQ helicases [ 18 ]. It is a multifunctional structure-specific nuclease, displaying an endonuclease activity on 5′-flap ssDNA or RNA substrates, a low-efficiency 5′→3...
Articles
Biochem J (2011) 436 (3): 559–566.
Published: 27 May 2011
...@u.washington.edu ). 9 11 2010 15 3 2011 4 4 2011 4 4 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 DNA repair DNA topoisomerase I proteasome tyrosyl-DNA phosphodiesterase (TDP) Cleavage of the DNA backbone by a topoisomerase is accompanied by...
Articles
Biochem J (2011) 436 (3): 671–679.
Published: 27 May 2011
... =5) was pooled prior to collection of PBMCs. Livers from control female mice ( n =3) and from oestradiol-treated female mice ( n =3) were also collected for analysis and stored at −80 °C. chemotherapy DNA repair poly(ADP-ribose) polymerase (PARP) poly(ADP-ribose) polymerase activity poly...
Includes: Supplementary data
Articles
Biochem J (2010) 430 (1): 119–128.
Published: 28 July 2010
... intermediates formed during DNA replication and gene expression. 1 email c.m.sanders@sheffield.ac.uk 21 4 2010 3 6 2010 4 6 2010 4 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 DNA repair DNA replication genome stability G-quadruplex DNA...
Includes: Supplementary data
Articles
Biochem J (2010) 426 (3): 365–371.
Published: 24 February 2010
...Catherine Chailleux; Sandrine Tyteca; Christophe Papin; François Boudsocq; Nadine Puget; Céline Courilleau; Mikhaïl Grigoriev; Yvan Canitrot; Didier Trouche Chromatin modifications and chromatin-modifying enzymes are believed to play a major role in the process of DNA repair. The histone acetyl...
Includes: Supplementary data
Articles
Biochem J (2009) 423 (2): 265–277.
Published: 25 September 2009
... Journal compilation © 2009 Biochemical Society 2009 DNA repair endonuclease MutL NgoL Neisseria gonorrhoeae The Gram-negative bacterial genus Neisseria contains many species that are only found in humans, including several commensal organisms that inhabit the nasopharynx and the...
Includes: Supplementary data
Articles
Biochem J (2009) 420 (2): 249–257.
Published: 13 May 2009
..., hence, this is the first report of expression of a DNA repair function being controlled by nitrate ions. 1 These authors have contributed equally to this work. 2 To whom correspondence should be addressed (email s.j.w.busby@bham.ac.uk ). 30 1 2009 24 2 2009 26 2 2009...
Articles
Biochem J (2008) 409 (1): 169–177.
Published: 11 December 2007
... organisms. It is required for the initiation of DNA replication and for DNA repair and DNA damage signalling. Experiments with fission yeast and Xenopus revealed that the TopBP1 homologues of these organisms are required for chromatin loading of the replication protein Cdc45 (cell division cycle 45). To...
Articles
Biochem J (2007) 401 (1): 1–11.
Published: 11 December 2006
... The Biochemical Society, London 2007 antioxidant cancer DNA repair nitric oxide reactive oxygen species In 1996, I co-authored in the Biochemical Journal an article speculating on the role of oxygen radicals and other ‘reactive species’ (RS; defined in the legend to Figure 1 ) in...
Articles
Biochem J (2006) 398 (3): 319–337.
Published: 29 August 2006
... Biochemical Society, London 2006 aging cancer DNA repair genomic instability helicase RecQ Understanding the molecular mechanisms of RecQ helicases is fundamental to deciphering the roles of these enzymes in cellular DNA metabolism. Since the discovery of Escherichia coli RecQ and its...
Articles
Biochem J (2006) 393 (1): 303–309.
Published: 12 December 2005
...Lyne Jossé; Margaret E. Harley; Isabel M. S. Pires; David A. Hughes Human DSS1 associates with BRCA2, a tumour suppressor protein required for efficient recombinational DNA repair, but the biochemical function of DSS1 is not known. Orthologues of DSS1 are found in organisms such as budding yeast...
Articles
Biochem J (2005) 387 (3): 859–863.
Published: 26 April 2005
... should be addressed (email sb419@hutchison-mrc.cam.ac.uk ). 30 9 2004 1 12 2004 10 12 2004 10 12 2004 The Biochemical Society, London 2005 DNA repair DNA replication proliferating cell nuclear antigen (PCNA) Sulfolobus uracil uracil DNA glycosylase (UDG...
Articles
Biochem J (2004) 379 (1): 71–78.
Published: 01 April 2004
... molecular mechanism of repairing the ICL damage has not been well established. We have studied the role of XPF (xeroderma pigmentosum group F) protein in psoralen-induced ICL-mediated DNA repair and mutagenesis. The results obtained from our mutagenesis studies revealed a very similar mutation frequency in...
Articles
Biochem J (2003) 375 (2): 449–455.
Published: 15 October 2003
...Sreenivas KANUGULA; Anthony E. PEGG AGT ( O 6 -alkylguanine DNA alkyltransferase) is an important DNA-repair protein that protects cells from killing and mutagenesis by alkylating agents. The AGT genes from two extremely thermophilic organisms, the bacterium Aquifex aeolicus and the archaeon...
Articles
Biochem J (2003) 374 (3): 577–606.
Published: 15 September 2003
... cancer predisposition chromosomal instability DNA repair progeroid syndrome RecQ helicase topoisomerase Abbreviations used: ALT, alternative lengthening of telomeres; AT, ataxia telangiectasia; ATM, ataxia telangiectasia mutated; ATP[γS], adenosine 5′-[γ-thio]triphosphate; ATR, ataxia...
Articles
Biochem J (2003) 372 (2): 651–660.
Published: 01 June 2003
... 2003 cisplatin DNA repair high-mobility group mis-match mutation avoidance Abbreviations used: cisplatin, cis -diammine-dichloroplatinum(II) ( cis -denotes a cisplatin adduct); Cmb, cytosine-mismatch binding; Cmb1Δ41 (etc.), Cmb1 from which the 41 N-terminal amino acids have been...
Articles
Biochem J (2002) 365 (3): 833–840.
Published: 01 August 2002
... functional AP endonuclease designated SuAP1. 1 These authors contributed equally to this work. 2 To whom correspondence should be addressed (e-mail maggy@alpha.szn.it ). 19 12 2001 22 3 2002 15 4 2002 The Biochemical Society, London ©2002 2002 development DNA repair...
Articles
Biochem J (2000) 352 (3): 801–808.
Published: 08 December 2000
...) whose activity was increased during DEN-induced hepatocarcinogenesis and also by digestion with endopeptidase Glu-C (V8 protease). endopeptidase Glu-C DNA repair hepatocarcinogenesis rat 1 To whom correspondence should be addressed (e-mail iklim@madang.ajou.ac.kr ). 30 5 2000...
Articles
Biochem J (2000) 347 (2): 363–368.
Published: 10 April 2000
... recombination. 1 To whom correspondence should be addressed (e-mail norris@;waksman.rutgers.edu). 20 10 1999 5 1 2000 21 1 2000 The Biochemical Society, London © 2000 2000 DNA repair heteroduplex DNA recombination Biochem. J. (2000) 347, 363 368 (Printed in Great Britain...
Articles
Biochem J (2000) 347 (2): 527–534.
Published: 10 April 2000
...Meng XU-WELLIVER; Sreenivas KANUGULA; Natalia A. LOKTIONOVA; Tina M. CRONE; Anthony E. PEGG The role of lysine 165 in the activity of the DNA repair protein, O 6 -alkylguanine-DNA alkyltransferase (AGT), and the ability of AGT to react with the pseudosubstrate inhibitor, O 6 -benzylguanine (BG...
Articles
Biochem J (1999) 342 (2): 249–268.
Published: 24 August 1999
... supported by the identification of direct protein-protein interactions involving poly(ADP-ribose) polymerase (113 kDa PARP), an enzyme catalysing the formation of poly(ADP-ribose), and key effectors of DNA repair, replication and transcription reactions. The presence of PARP in these multiprotein complexes...
Articles
Biochem J (1999) 337 (2): 311–317.
Published: 08 January 1999
... slee@iupui.edu ). 10 8 1998 1 10 1998 29 10 1998 The Biochemical Society, London © 1999 1999 DNA replication DNA repair Xeroderma pigmentosum group A complementing protein single-stranded DNA binding Biochem. J. (1999) 337, 311 317 (Printed in Great Britain) 311 In...