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1-32 of 32
Keywords: DNA replication
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Articles
Journal:
Biochemical Journal
Biochem J (2024) 481 (14): 923–944.
Published: 10 July 2024
... not only in the initiation of DNA replication and DNA damage repair but also in the efficient termination of these processes. In this review, we discuss our current understanding of how different Ub E3 ligases (RNF168, TRAIP, HUWE1, TRIP12, FANCL, BRCA1, RFWD3) function to regulate DNA repair...
Articles
Characterization of Streptococcus pneumoniae PriA helicase and its ATPase and unwinding activities in DNA replication restart
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Journal:
Biochemical Journal
Biochem J (2020) 477 (19): 3911–3922.
Published: 16 October 2020
...Min-Guan Lin; Yi-Ching Li; Chwan-Deng Hsiao DNA replication forks often encounter template DNA lesions that can stall their progression. The PriA-dependent pathway is the major replication restart mechanism in Gram-positive bacteria, and it requires several primosome proteins. Among them, PriA...
Includes: Supplementary data
Articles
Escherichia coli and Neisseria gonorrhoeae UvrD helicase unwinds G4 DNA structures
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2017) 474 (21): 3579–3597.
Published: 18 October 2017
...Kaustubh Shukla; Roshan Singh Thakur; Debayan Ganguli; Desirazu Narasimha Rao; Ganesh Nagaraju G-quadruplex (G4) secondary structures have been implicated in various biological processes, including gene expression, DNA replication and telomere maintenance. However, unresolved G4 structures impede...
Includes: Supplementary data
Articles
miR-30a can inhibit DNA replication by targeting RPA1 thus slowing cancer cell proliferation
Available to PurchaseZhenyou Zou, Mengjie Ni, Jing Zhang, Yongfeng Chen, Hongyu Ma, Shihan Qian, Longhua Tang, Jiamei Tang, Hailun Yao, Chengbin Zhao, Xiongwen Lu, Hongyang Sun, Jue Qian, Xiaoting Mao, Xulin Lu, Qun Liu, Juping Zen, Hanbing Wu, Zhaosheng Bao, Shudan Lin, Hongyu Sheng, Yunlong Li, Yong Liang, Zhiqiang Chen, Dan Zong
Journal:
Biochemical Journal
Biochem J (2016) 473 (14): 2131–2139.
Published: 12 July 2016
... Chen; Dan Zong Cell proliferation was inhibited following forced over-expression of miR-30a in the ovary cancer cell line A2780DX5 and the gastric cancer cell line SGC7901R. Interestingly, miR-30a targets the DNA replication protein RPA1, hinders the replication of DNA and induces DNA fragmentation...
Articles
Functional dissection of proliferating-cell nuclear antigens (1 and 2) in human malarial parasite Plasmodium falciparum: possible involvement in DNA replication and DNA damage response
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Journal:
Biochemical Journal
Biochem J (2015) 470 (1): 115–129.
Published: 06 August 2015
...Pallabi Mitra; Khadija Banu; Abhijit S. Deshmukh; Naidu Subbarao; Suman Kumar Dhar Eukaryotic PCNAs (proliferating-cell nuclear antigens) play diverse roles in nucleic acid metabolism in addition to DNA replication. Plasmodium falciparum , which causes human malaria, harbours two PCNA homologues...
Includes: Multimedia, Supplementary data
Articles
The architecture of an Okazaki fragment-processing holoenzyme from the archaeon Sulfolobus solfataricus
Open Access
Journal:
Biochemical Journal
Biochem J (2015) 465 (2): 239–245.
Published: 06 January 2015
...Giuseppe Cannone; Yuli Xu; Thomas R. Beattie; Stephen D. Bell; Laura Spagnolo DNA replication on the lagging strand occurs via the synthesis and maturation of Okazaki fragments. In archaea and eukaryotes, the enzymatic activities required for this process are supplied by a replicative DNA...
Includes: Supplementary data
Articles
The physical interaction of Mcm10 with Cdc45 modulates their DNA-binding properties
Available to PurchaseRoberta Di Perna, Valentina Aria, Mariarosaria De Falco, Vincenzo Sannino, Andrei L. Okorokov, Francesca M. Pisani, Mariarita De Felice
Journal:
Biochemical Journal
Biochem J (2013) 454 (2): 333–343.
Published: 09 August 2013
...Roberta Di Perna; Valentina Aria; Mariarosaria De Falco; Vincenzo Sannino; Andrei L. Okorokov; Francesca M. Pisani; Mariarita De Felice The eukaryotic DNA replication protein Mcm10 (mini-chromosome maintenance 10) associates with chromatin in early S-phase and is required for assembly and function...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2013) 449 (3): 673–681.
Published: 09 January 2013
...Haitao Wang; Jiaxin Gao; Ada Hang-Heng Wong; Kangdi Hu; Wanjie Li; Yue Wang; Jianli Sang Rfa2 is a ssDNA (single-stranded DNA)-binding protein that plays an important role in DNA replication, recombination and repair. Rfa2 is regulated by phosphorylation, which alters its protein–protein...
Includes: Supplementary data
Articles
Temperature-dependence of the DnaA–DNA interaction and its effect on the autoregulation of dnaA expression
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Journal:
Biochemical Journal
Biochem J (2013) 449 (2): 333–341.
Published: 14 December 2012
...Chiara Saggioro; Anne Olliver; Bianca Sclavi The DnaA protein is a key factor for the regulation of the timing and synchrony of initiation of bacterial DNA replication. The transcription of the dnaA gene in Escherichia coli is regulated by two promoters, dnaAP1 and dnaAP2 . The region between...
Includes: Supplementary data
Articles
Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906
Available to PurchaseDaniele G. Soares, Aude Battistella, Céline J. Rocca, Renata Matuo, João A. P. Henriques, Annette K. Larsen, Alexandre E. Escargueil
Journal:
Biochemical Journal
Biochem J (2011) 437 (1): 63–73.
Published: 14 June 2011
... autophosphorylation of the Ser 1981 residue leading to formation of catalytically active monomers [ 3 ]. In comparison, the primary function of ATR is to monitor DNA replication [ 5 ]. ATR regulates the firing of replication origins and the repair of damaged replication forks, and is activated to prevent...
Includes: Supplementary data
Articles
ATR signalling: more than meeting at the fork
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Journal:
Biochemical Journal
Biochem J (2011) 436 (3): 527–536.
Published: 27 May 2011
...Edward A. Nam; David Cortez Preservation of genome integrity via the DNA-damage response is critical to prevent disease. ATR (ataxia telangiectasia mutated- and Rad3-related) is essential for life and functions as a master regulator of the DNA-damage response, especially during DNA replication. ATR...
Articles
The interplay of DNA binding, ATP hydrolysis and helicase activities of the archaeal MCM helicase
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Journal:
Biochemical Journal
Biochem J (2011) 436 (2): 409–414.
Published: 13 May 2011
... active site. 1 To whom correspondence should be addressed (email [email protected] ). 13 1 2011 16 2 2011 1 3 2011 1 3 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 AAA+ ATPase archaea DNA replication helicase...
Includes: Supplementary data
Articles
Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity
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Journal:
Biochemical Journal
Biochem J (2010) 430 (1): 119–128.
Published: 28 July 2010
... intermediates formed during DNA replication and gene expression. DNA repair DNA replication genome stability G-quadruplex DNA (G4 DNA) Pif1 helicase protein–DNA interactions DNA can adopt structures other than the canonical B-form duplex stabilized by Watson–Crick base pairing. Structures...
Includes: Supplementary data
Articles
Effect of 8-oxoguanine and abasic site DNA lesions on in vitro elongation by human DNA polymerase ϵ in the presence of replication protein A and proliferating-cell nuclear antigen
Available to PurchaseGiada A. Locatelli, Helmut Pospiech, Nicolas Tanguy Le Gac, Barbara van Loon, Ulrich Hubscher, Sinikka Parkkinen, Juhani E. Syväoja, Giuseppe Villani
Journal:
Biochemical Journal
Biochem J (2010) 429 (3): 573–582.
Published: 14 July 2010
... (email [email protected] ). 19 3 2010 28 5 2010 8 6 2010 8 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 7,8-dihydro-8-oxoguanine DNA replication DNA polymerase DNA damage proliferating-cell nuclear antigen (PCNA) replication...
Includes: Supplementary data
Articles
Structure and function of the GINS complex, a key component of the eukaryotic replisome
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Journal:
Biochemical Journal
Biochem J (2010) 425 (3): 489–500.
Published: 15 January 2010
...Stuart A. MacNeill High-fidelity chromosomal DNA replication is fundamental to all forms of cellular life and requires the complex interplay of a wide variety of essential and non-essential protein factors in a spatially and temporally co-ordinated manner. In eukaryotes, the GINS complex (from...
Includes: Supplementary data
Articles
Analysis of mutant origin recognition complex with reduced ATPase activity in vivo and in vitro
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Journal:
Biochemical Journal
Biochem J (2008) 413 (3): 535–543.
Published: 15 July 2008
...Masaya Takehara; Masaki Makise; Hitomi Takenaka; Teita Asano; Tohru Mizushima In eukaryotes, ORC (origin recognition complex), a six-protein complex, is the most likely initiator of chromosomal DNA replication. ORC belongs to the AAA + (ATPases associated with a variety of cellular activities...
Includes: Supplementary data
Articles
A conserved mechanism for replication origin recognition and binding in archaea
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Journal:
Biochemical Journal
Biochem J (2008) 409 (2): 511–518.
Published: 21 December 2007
...Alan I. Majerník; James P. J. Chong To date, methanogens are the only group within the archaea where firing DNA replication origins have not been demonstrated in vivo . In the present study we show that a previously identified cluster of ORB (origin recognition box) sequences do indeed function...
Includes: Supplementary data
Articles
Genetic analysis reveals essential and non-essential amino acids within the telomeric DNA-binding interface of Cdc13p
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Journal:
Biochemical Journal
Biochem J (2007) 403 (2): 289–295.
Published: 26 March 2007
... of these authors (email [email protected] or [email protected] ). Cdc13 DNA replication telomere binding telomere structure yeast two-hybrid In eukaryotic cells, the end of the linear chromosomes are composed of special nucleoprotein complexes known as telomeres, which are essential for chromosome...
Articles
Mechanism for the degradation of origin recognition complex containing Orc5p with a defective Walker A motif and its suppression by over-production of Orc4p in yeast cells
Available to PurchaseMasaki Makise, Naoko Takahashi, Kazuya Matsuda, Fumiko Yamairi, Keitarou Suzuki, Tomofusa Tsuchiya, Tohru Mizushima
Journal:
Biochemical Journal
Biochem J (2007) 402 (2): 397–403.
Published: 12 February 2007
...Masaki Makise; Naoko Takahashi; Kazuya Matsuda; Fumiko Yamairi; Keitarou Suzuki; Tomofusa Tsuchiya; Tohru Mizushima Orc5p is one of six subunits constituting the ORC (origin recognition complex), a possible initiator of chromosomal DNA replication in eukaryotes. Orc5p contains a Walker A motif. We...
Articles
TopBP1 contains a transcriptional activation domain suppressed by two adjacent BRCT domains
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Journal:
Biochemical Journal
Biochem J (2006) 400 (3): 573–582.
Published: 28 November 2006
...Roni H. G. Wright; Edward S. Dornan; Mary M. Donaldson; Iain M. Morgan TopBP1 has eight BRCT [BRCA1 (breast-cancer susceptibility gene 1) C-terminus] domains and is involved in initiating DNA replication, and DNA damage checkpoint signalling and repair. Several BRCT-domain-containing proteins...
Articles
Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants
Available to PurchaseGiada A. Locatelli, Monica Savio, Luca Forti, Igor Shevelev, Kristijan Ramadan, Lucia A. Stivala, Vanio Vannini, Ulrich Hübscher, Silvio Spadari, Giovanni Maga
Journal:
Biochemical Journal
Biochem J (2005) 389 (2): 259–268.
Published: 05 July 2005
... suppress the in vitro SV40 DNA replication. The potency of inhibition is similar to that of aphidicolin, an inhibitor of the three replicative pols α, δ and ε. Our findings establish the necessary background for the synthesis of resveratrol derivatives having more selective and potent antiproliferative...
Articles
Helicobacter pylori DnaB helicase can bypass Escherichia coli DnaC function in vivo
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Journal:
Biochemical Journal
Biochem J (2005) 389 (2): 541–548.
Published: 05 July 2005
...Rajesh K. Soni; Parul Mehra; Gauranga Mukhopadhyay; Suman Kumar Dhar In Escherichia coli , DnaC is essential for loading DnaB helicase at ori C (the origin of chromosomal DNA replication). The question arises as to whether this model can be generalized to other species, since many eubacterial...
Articles
Characterization of an archaeal family 4 uracil DNA glycosylase and its interaction with PCNA and chromatin proteins
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Journal:
Biochemical Journal
Biochem J (2005) 387 (3): 859–863.
Published: 26 April 2005
... ). 30 9 2004 1 12 2004 10 12 2004 10 12 2004 The Biochemical Society, London 2005 DNA repair DNA replication proliferating cell nuclear antigen (PCNA) Sulfolobus uracil uracil DNA glycosylase (UDG) PCNA (proliferating cell nuclear antigen) is a toroidal...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 386 (3): 557–566.
Published: 08 March 2005
...Hans-Jörg RIEDINGER; Frank EGER; Klaus TRUMMLER; Hans PROBST SV40 (simian virus 40)-infected CV1 cells were permeabilized with Staphylococcus aureus α-toxin for small molecules (<2 kDa) in a medium that supports DNA replication. Incorporation of [α- 32 P]dATP was shown to proceed...
Articles
Dysfunctional proofreading in the Escherichia coli DNA polymerase III core
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Journal:
Biochemical Journal
Biochem J (2004) 384 (2): 337–348.
Published: 23 November 2004
... should be addressed (email [email protected] ). 21 4 2004 23 8 2004 7 9 2004 7 9 2004 The Biochemical Society, London 2004 DNA polymerase DNA replication exonuclease fidelity mutator proofreading The DNA pol III (DNA polymerase III) holoenzyme...
Includes: Supplementary data
Articles
Modular organization of a Cdc6-like protein from the crenarchaeon Sulfolobus solfataricus
Available to PurchaseMariarita DE FELICE, Luca ESPOSITO, Biagio PUCCI, Mariarosaria DE FALCO, Giuseppe MANCO, Mosè ROSSI, Francesca M. PISANI
Journal:
Biochemical Journal
Biochem J (2004) 381 (3): 645–653.
Published: 27 July 2004
.... The reaction products were quantified, and any free oligonucleotide in the absence of enzyme was subtracted. Archaea DNA helicase DNA replication helicaseloader Sulfolobus solfataricus thermophilic organism The initiation of chromosomal DNA replication is of fundamental importance...
Articles
Quantitative analysis of nucleotide modulation of DNA binding by DnaC protein of Escherichia coli
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Journal:
Biochemical Journal
Biochem J (2004) 379 (3): 553–562.
Published: 01 May 2004
...Subhasis B. BISWAS; Stephen FLOWERS; Esther E. BISWAS-FISS In this study, we have presented the first report of Escherichia coli DnaC protein binding to ssDNA (single stranded DNA) in an apparent hexameric form. DnaC protein transfers DnaB helicase onto a nascent chromosomal DNA replication fork...
Articles
Conserved hydrophobic amino acid residues in the N-terminal region of DnaA protein are involved in DnaA–DnaA interaction
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Journal:
Biochemical Journal
Biochem J (2002) 365 (3): 881–887.
Published: 01 August 2002
... conserved hydrophobic amino acid residues, L3, L10 and L17, and examined the function of DnaA proteins mutated in these amino acid residues. DnaA427 (L17S) and DnaA413 (L3S, L10S and L17S) were inactive for oriC DNA replication both in vitro and in vivo . Although these mutant DnaA proteins maintained...
Articles
Inhibitory effects of acidic phospholipids on the binding of origin-recognition complex to origin DNA
Available to PurchaseJong-Ryul LEE, Masaki MAKISE, Hitomi TAKENAKA, Naoko TAKAHASHI, Yoshihiro YAMAGUCHI, Tomofusa TSUCHIYA, Tohru MIZUSHIMA
Journal:
Biochemical Journal
Biochem J (2002) 362 (2): 395–399.
Published: 22 February 2002
...Jong-Ryul LEE; Masaki MAKISE; Hitomi TAKENAKA; Naoko TAKAHASHI; Yoshihiro YAMAGUCHI; Tomofusa TSUCHIYA; Tohru MIZUSHIMA Origin-recognition complex (ORC), a candidate initiator of chromosomal DNA replication in eukaryotes, shares certain biochemical characteristics with DnaA, the initiator...
Articles
Suppression of temperature-sensitivity of a dnaA46 mutant by excessive DNA supercoiling
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Journal:
Biochemical Journal
Biochem J (2000) 348 (2): 375–379.
Published: 23 May 2000
... is involved in the suppression of the temperature-sensitivity of the dnaA46 mutant by high concentrations of NaCl. This hypothesis was supported by in vitro and in vivo results as follows. A low DNA replication activity of purified DnaA46 protein at high temperatures was increased in line with an increase...
Articles
Recognition of DNA alterations by the mismatch repair system
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Journal:
Biochemical Journal
Biochem J (1999) 338 (1): 1–13.
Published: 08 February 1999
...Giancarlo MARRA; Primo SCHÄR Misincorporation of non-complementary bases by DNA polymerases is a major source of the occurrence of promutagenic base-pairing errors during DNA replication or repair. Base–base mismatches or loops of extra bases can arise which, if left unrepaired, will generate point...
Articles
In vitro analysis of the zinc-finger motif in human replication protein A
Available to Purchase
Journal:
Biochemical Journal
Biochem J (1999) 337 (2): 311–317.
Published: 08 January 1999
.... To study the role of this domain in DNA metabolism, we created various p70 mutants that lack the zinc-finger motif (by Cys → Ala substitutions). Mutation at the zinc-finger domain (ZFM) abolished RPA's function in nucleotide excision repair (NER), but had very little impact on DNA replication. The failure...
