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1-32 of 32
Keywords: DNA replication
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Articles
Journal:
Biochemical Journal
Biochem J (2024) 481 (14): 923–944.
Published: 10 July 2024
... not only in the initiation of DNA replication and DNA damage repair but also in the efficient termination of these processes. In this review, we discuss our current understanding of how different Ub E3 ligases (RNF168, TRAIP, HUWE1, TRIP12, FANCL, BRCA1, RFWD3) function to regulate DNA repair...
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (19): 3911–3922.
Published: 16 October 2020
...Min-Guan Lin; Yi-Ching Li; Chwan-Deng Hsiao DNA replication forks often encounter template DNA lesions that can stall their progression. The PriA-dependent pathway is the major replication restart mechanism in Gram-positive bacteria, and it requires several primosome proteins. Among them, PriA...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (21): 3579–3597.
Published: 18 October 2017
...Kaustubh Shukla; Roshan Singh Thakur; Debayan Ganguli; Desirazu Narasimha Rao; Ganesh Nagaraju G-quadruplex (G4) secondary structures have been implicated in various biological processes, including gene expression, DNA replication and telomere maintenance. However, unresolved G4 structures impede...
Includes: Supplementary data
Articles
Zhenyou Zou, Mengjie Ni, Jing Zhang, Yongfeng Chen, Hongyu Ma, Shihan Qian, Longhua Tang, Jiamei Tang, Hailun Yao, Chengbin Zhao, Xiongwen Lu, Hongyang Sun, Jue Qian, Xiaoting Mao, Xulin Lu, Qun Liu, Juping Zen, Hanbing Wu, Zhaosheng Bao, Shudan Lin, Hongyu Sheng, Yunlong Li, Yong Liang, Zhiqiang Chen, Dan Zong
Journal:
Biochemical Journal
Biochem J (2016) 473 (14): 2131–2139.
Published: 12 July 2016
... Chen; Dan Zong Cell proliferation was inhibited following forced over-expression of miR-30a in the ovary cancer cell line A2780DX5 and the gastric cancer cell line SGC7901R. Interestingly, miR-30a targets the DNA replication protein RPA1, hinders the replication of DNA and induces DNA fragmentation...
Articles
Journal:
Biochemical Journal
Biochem J (2015) 470 (1): 115–129.
Published: 06 August 2015
...Pallabi Mitra; Khadija Banu; Abhijit S. Deshmukh; Naidu Subbarao; Suman Kumar Dhar Eukaryotic PCNAs (proliferating-cell nuclear antigens) play diverse roles in nucleic acid metabolism in addition to DNA replication. Plasmodium falciparum , which causes human malaria, harbours two PCNA homologues...
Includes: Multimedia, Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2015) 465 (2): 239–245.
Published: 06 January 2015
...Giuseppe Cannone; Yuli Xu; Thomas R. Beattie; Stephen D. Bell; Laura Spagnolo DNA replication on the lagging strand occurs via the synthesis and maturation of Okazaki fragments. In archaea and eukaryotes, the enzymatic activities required for this process are supplied by a replicative DNA...
Includes: Supplementary data
Articles
Roberta Di Perna, Valentina Aria, Mariarosaria De Falco, Vincenzo Sannino, Andrei L. Okorokov, Francesca M. Pisani, Mariarita De Felice
Journal:
Biochemical Journal
Biochem J (2013) 454 (2): 333–343.
Published: 09 August 2013
...Roberta Di Perna; Valentina Aria; Mariarosaria De Falco; Vincenzo Sannino; Andrei L. Okorokov; Francesca M. Pisani; Mariarita De Felice The eukaryotic DNA replication protein Mcm10 (mini-chromosome maintenance 10) associates with chromatin in early S-phase and is required for assembly and function...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2013) 449 (3): 673–681.
Published: 09 January 2013
...Haitao Wang; Jiaxin Gao; Ada Hang-Heng Wong; Kangdi Hu; Wanjie Li; Yue Wang; Jianli Sang Rfa2 is a ssDNA (single-stranded DNA)-binding protein that plays an important role in DNA replication, recombination and repair. Rfa2 is regulated by phosphorylation, which alters its protein–protein...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2013) 449 (2): 333–341.
Published: 14 December 2012
...Chiara Saggioro; Anne Olliver; Bianca Sclavi The DnaA protein is a key factor for the regulation of the timing and synchrony of initiation of bacterial DNA replication. The transcription of the dnaA gene in Escherichia coli is regulated by two promoters, dnaAP1 and dnaAP2 . The region between...
Includes: Supplementary data
Articles
Daniele G. Soares, Aude Battistella, Céline J. Rocca, Renata Matuo, João A. P. Henriques, Annette K. Larsen, Alexandre E. Escargueil
Journal:
Biochemical Journal
Biochem J (2011) 437 (1): 63–73.
Published: 14 June 2011
... represent the means of at least two independent experiments. 8 11 2010 4 4 2011 7 4 2011 7 4 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 checkpoint control DNA alkylator DNA-damage response DNA replication Eukaryotic cells have...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2011) 436 (3): 527–536.
Published: 27 May 2011
...Edward A. Nam; David Cortez Preservation of genome integrity via the DNA-damage response is critical to prevent disease. ATR (ataxia telangiectasia mutated- and Rad3-related) is essential for life and functions as a master regulator of the DNA-damage response, especially during DNA replication. ATR...
Articles
Journal:
Biochemical Journal
Biochem J (2011) 436 (2): 409–414.
Published: 13 May 2011
... Journal compilation © 2011 Biochemical Society 2011 AAA+ ATPase archaea DNA replication helicase minichromosome maintenance (MCM) Sulfolobus In the present study we address the roles of a cluster of highly conserved residues that occupy a pivotal position in SsoMCM, lying...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2010) 430 (1): 119–128.
Published: 28 July 2010
... intermediates formed during DNA replication and gene expression. The purified full-length nuclear form of hPif1 and the core helicase domain (amino acids 206–620 of 641) were generated in Escherichia coli BL21(DE3) as GST (glutathione transferase) fusion proteins as described previously [ 28 ]. Briefly...
Includes: Supplementary data
Articles
Giada A. Locatelli, Helmut Pospiech, Nicolas Tanguy Le Gac, Barbara van Loon, Ulrich Hubscher, Sinikka Parkkinen, Juhani E. Syväoja, Giuseppe Villani
Journal:
Biochemical Journal
Biochem J (2010) 429 (3): 573–582.
Published: 14 July 2010
... of the processivity factor PCNA (proliferating-cell nuclear antigen) [ 11 ]. Efficient and accurate replication of the eukaryotic genome requires not only DNA pols α and δ, but also DNA pol ϵ. Recent work in yeast supports a model wherein, during normal DNA replication, DNA pol ϵ is primarily responsible...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2010) 425 (3): 489–500.
Published: 15 January 2010
...Stuart A. MacNeill High-fidelity chromosomal DNA replication is fundamental to all forms of cellular life and requires the complex interplay of a wide variety of essential and non-essential protein factors in a spatially and temporally co-ordinated manner. In eukaryotes, the GINS complex (from...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2008) 413 (3): 535–543.
Published: 15 July 2008
...Masaya Takehara; Masaki Makise; Hitomi Takenaka; Teita Asano; Tohru Mizushima In eukaryotes, ORC (origin recognition complex), a six-protein complex, is the most likely initiator of chromosomal DNA replication. ORC belongs to the AAA + (ATPases associated with a variety of cellular activities...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2008) 409 (2): 511–518.
Published: 21 December 2007
...Alan I. Majerník; James P. J. Chong To date, methanogens are the only group within the archaea where firing DNA replication origins have not been demonstrated in vivo . In the present study we show that a previously identified cluster of ORB (origin recognition box) sequences do indeed function...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2007) 403 (2): 289–295.
Published: 26 March 2007
... , cdc13 - 5 , extends the G-rich DNA in telomeres [ 13 , 21 ]. This evidence indicates that Cdc13p has a dual role in maintaining telomere length. Cdc13 DNA replication telomere binding telomere structure yeast two-hybrid In eukaryotic cells, the end of the linear chromosomes are composed...
Articles
Masaki Makise, Naoko Takahashi, Kazuya Matsuda, Fumiko Yamairi, Keitarou Suzuki, Tomofusa Tsuchiya, Tohru Mizushima
Journal:
Biochemical Journal
Biochem J (2007) 402 (2): 397–403.
Published: 12 February 2007
...Masaki Makise; Naoko Takahashi; Kazuya Matsuda; Fumiko Yamairi; Keitarou Suzuki; Tomofusa Tsuchiya; Tohru Mizushima Orc5p is one of six subunits constituting the ORC (origin recognition complex), a possible initiator of chromosomal DNA replication in eukaryotes. Orc5p contains a Walker A motif. We...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 400 (3): 573–582.
Published: 28 November 2006
...Roni H. G. Wright; Edward S. Dornan; Mary M. Donaldson; Iain M. Morgan TopBP1 has eight BRCT [BRCA1 (breast-cancer susceptibility gene 1) C-terminus] domains and is involved in initiating DNA replication, and DNA damage checkpoint signalling and repair. Several BRCT-domain-containing proteins...
Articles
Giada A. Locatelli, Monica Savio, Luca Forti, Igor Shevelev, Kristijan Ramadan, Lucia A. Stivala, Vanio Vannini, Ulrich Hübscher, Silvio Spadari, Giovanni Maga
Journal:
Biochemical Journal
Biochem J (2005) 389 (2): 259–268.
Published: 05 July 2005
... suppress the in vitro SV40 DNA replication. The potency of inhibition is similar to that of aphidicolin, an inhibitor of the three replicative pols α, δ and ε. Our findings establish the necessary background for the synthesis of resveratrol derivatives having more selective and potent antiproliferative...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 389 (2): 541–548.
Published: 05 July 2005
...Rajesh K. Soni; Parul Mehra; Gauranga Mukhopadhyay; Suman Kumar Dhar In Escherichia coli , DnaC is essential for loading DnaB helicase at ori C (the origin of chromosomal DNA replication). The question arises as to whether this model can be generalized to other species, since many eubacterial...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 387 (3): 859–863.
Published: 26 April 2005
... gradient of 150–1000 mM NaCl. The UDG1 protein was eluted at 600 mM NaCl. PCNA (proliferating cell nuclear antigen) is a toroidal molecule that acts as a sliding clamp, tethering a number of DNA replication and repair factors to DNA [ 1 , 2 ]. Homologues of PCNA are found throughout the archaeal...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 386 (3): 557–566.
Published: 08 March 2005
...Hans-Jörg RIEDINGER; Frank EGER; Klaus TRUMMLER; Hans PROBST SV40 (simian virus 40)-infected CV1 cells were permeabilized with Staphylococcus aureus α-toxin for small molecules (<2 kDa) in a medium that supports DNA replication. Incorporation of [α- 32 P]dATP was shown to proceed...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 384 (2): 337–348.
Published: 23 November 2004
... 7 9 2004 7 9 2004 The Biochemical Society, London 2004 DNA polymerase DNA replication exonuclease fidelity mutator proofreading The DNA pol III (DNA polymerase III) holoenzyme of Escherichia coli is a multi-subunit replicase consisting of at least 10 different...
Includes: Supplementary data
Articles
Mariarita DE FELICE, Luca ESPOSITO, Biagio PUCCI, Mariarosaria DE FALCO, Giuseppe MANCO, Mosè ROSSI, Francesca M. PISANI
Journal:
Biochemical Journal
Biochem J (2004) 381 (3): 645–653.
Published: 27 July 2004
... electrophoresis, the gel was soaked in 20% trichloroacetic acid and analysed using a PhosphorImager. The reaction products were quantified, and any free oligonucleotide in the absence of enzyme was subtracted. Archaea DNA helicase DNA replication helicaseloader Sulfolobus solfataricus thermophilic...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 379 (3): 553–562.
Published: 01 May 2004
...Subhasis B. BISWAS; Stephen FLOWERS; Esther E. BISWAS-FISS In this study, we have presented the first report of Escherichia coli DnaC protein binding to ssDNA (single stranded DNA) in an apparent hexameric form. DnaC protein transfers DnaB helicase onto a nascent chromosomal DNA replication fork...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 365 (3): 881–887.
Published: 01 August 2002
... conserved hydrophobic amino acid residues, L3, L10 and L17, and examined the function of DnaA proteins mutated in these amino acid residues. DnaA427 (L17S) and DnaA413 (L3S, L10S and L17S) were inactive for oriC DNA replication both in vitro and in vivo . Although these mutant DnaA proteins maintained...
Articles
Jong-Ryul LEE, Masaki MAKISE, Hitomi TAKENAKA, Naoko TAKAHASHI, Yoshihiro YAMAGUCHI, Tomofusa TSUCHIYA, Tohru MIZUSHIMA
Journal:
Biochemical Journal
Biochem J (2002) 362 (2): 395–399.
Published: 22 February 2002
...Jong-Ryul LEE; Masaki MAKISE; Hitomi TAKENAKA; Naoko TAKAHASHI; Yoshihiro YAMAGUCHI; Tomofusa TSUCHIYA; Tohru MIZUSHIMA Origin-recognition complex (ORC), a candidate initiator of chromosomal DNA replication in eukaryotes, shares certain biochemical characteristics with DnaA, the initiator...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 348 (2): 375–379.
Published: 23 May 2000
... is involved in the suppression of the temperature-sensitivity of the dnaA46 mutant by high concentrations of NaCl. This hypothesis was supported by in vitro and in vivo results as follows. A low DNA replication activity of purified DnaA46 protein at high temperatures was increased in line with an increase...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 338 (1): 1–13.
Published: 08 February 1999
...Giancarlo MARRA; Primo SCHÄR Misincorporation of non-complementary bases by DNA polymerases is a major source of the occurrence of promutagenic base-pairing errors during DNA replication or repair. Base–base mismatches or loops of extra bases can arise which, if left unrepaired, will generate point...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 337 (2): 311–317.
Published: 08 January 1999
.... To study the role of this domain in DNA metabolism, we created various p70 mutants that lack the zinc-finger motif (by Cys → Ala substitutions). Mutation at the zinc-finger domain (ZFM) abolished RPA's function in nucleotide excision repair (NER), but had very little impact on DNA replication. The failure...
