... DNA synthesis and repair point mutations Inosine, a purine nucleoside containing hypoxanthine (HX) nucleobase, was first identified in 1965 as the deamination product of adenosine [ 1 ]. Inosine formation in RNA is a major biological mechanism underlying RNA editing [ 1 ]. Additionally...

... the Creative Commons Attribution License 4.0 (CC BY) . BRC repeat BRCA2 DNA synthesis and repair homologous recombination RAD51 Genomic integrity is critical for the survival of all forms of life, and successful repair of DNA lesions is an essential function of the cell. Eukaryotes have...

...), thereby confirming that CUL2 LRR1 activates UBE2D2 to mono-ubiquitylate CMG-MCM7. CMG helicase CUL2LRR1 cullin ligase DNA synthesis and repair p97 ubiquitins Eukaryotic cells synthesise a single copy of their chromosomes in each cell cycle [ 1–3 ]. The control of chromosome duplication...

... 12 2019 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 apoptosis autophagy breast cancers DNA synthesis and repair lysosomes transcriptomics Breast cancer is a leading cause of death among women. Notably, five-year...

... on behalf of the Biochemical Society 2017 DNA replication DNA synthesis and repair genome integrity G-quadruplex helicase In the present study, we demonstrate a novel role of EcUvrD and Neisseria gonorrhoeae UvrD (NgUvrD) helicase in unwinding G4 DNA secondary structures. Purified EcUvrD...