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Keywords: Drosophila
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Articles
Biochem J (2019) 476 (4): 759–768.
Published: 28 February 2019
... regulation of cell proliferation and apoptosis. Here, we report on the roles of Hcf (host cell factor), the Drosophila homolog of Host cell factor 1, in regulating the Hippo signaling pathway. Loss-of-Hcf function causes tissue undergrowth and the down-regulation of Hippo target gene expression. Genetic...
Includes: Supplementary data
Articles
Biochem J (2015) 470 (2): 255–262.
Published: 20 August 2015
...-GlcNAcylation as a function of Drosophila development. 1 These authors contributed equally to this work. 2 To whom correspondence should be addressed (email dmfvanaalten@dundee.ac.uk ). 26 5 2015 30 6 2015 14 7 2015 14 7 2015 © 2015 Authors; published by Portland...
Includes: Supplementary data
Articles
Biochem J (2014) 463 (1): 31–40.
Published: 08 September 2014
... formation and prion-induced neurotoxicity during prion disease remains undefined. In the present study we investigated whether Drosophila transgenic for ovine PrP targeted to the plasma membrane, to the cytosol or for secretion, could produce transmissible toxicity following exposure to exogenous ovine...
Includes: Supplementary data
Articles
Biochem J (2013) 454 (3): 571–583.
Published: 29 August 2013
...Zoltán Lipinszki; Eva Klement; Eva Hunyadi-Gulyas; Katalin F. Medzihradszky; Róbert Márkus; Margit Pál; Péter Deák; Andor Udvardy The concentrations of the Drosophila proteasomal and extraproteasomal polyubiquitin receptors fluctuate in a developmentally regulated fashion. This fluctuation is...
Includes: Supplementary data
Articles
Biochem J (2012) 448 (2): 273–283.
Published: 07 November 2012
...Yixing Zhou; Shilan Wu; Huanchen Wang; Yoichi Hayakawa; Gary S. Bird; Stephen B. Shears Using immortalized [ 3 H]inositol-labelled S3 cells, we demonstrated in the present study that various elements of the inositol phosphate signalling cascade are recruited by a Drosophila homologue from a...
Includes: Supplementary data
Articles
Biochem J (2012) 444 (3): 487–495.
Published: 29 May 2012
...Alana M. Thackray; Farooq Muhammad; Chang Zhang; Ying Di; Thomas R. Jahn; Matthias Landgraf; Damian C. Crowther; Jan Felix Evers; Raymond Bujdoso Drosophila have emerged as a model system to study mammalian neurodegenerative diseases. In the present study we have generated Drosophila transgenic for...
Articles
Biochem J (2011) 439 (1): 151–159.
Published: 14 September 2011
... selectivity and the regulation of insulin signalling remain unclear. In the present study we have taken advantage of Drosophila as a model organism to establish the role of the SH3 (Src homology 3)/SH2 adaptor protein Dock (Dreadlocks) and its mammalian counterpart Nck in IR regulation by PTPs. We demonstrate...
Includes: Supplementary data
Articles
Biochem J (2011) 438 (3): 437–445.
Published: 26 August 2011
...Jonatan Sánchez; Ana Talamillo; Monika González; Luis Sánchez-Pulido; Silvia Jiménez; Lucia Pirone; James D. Sutherland; Rosa Barrio The SALL (Spalt-like) family of zinc-finger transcription factors is conserved in metazoans. In Drosophila Sal (Spalt) and Salr (Spalt-related) control the expression...
Includes: Supplementary data
Articles
Biochem J (2011) 433 (3): e3–e5.
Published: 14 January 2011
... cyclic GMP Science 2002 298 2006 2010 7 Katanaev V. L. Ponzielli R. Semeriva M. Tomlinson A. Trimeric G proteins-dependent Frizzled signaling in Drosophila Cell 2005 120 111 122 8 Egger-Adam D. Katanaev V. L. The trimeric G protein Go inflicts a...
Articles
Biochem J (2009) 421 (3): 463–471.
Published: 15 July 2009
.../4 expression. Zebrafish mitoferrin1 ( mfrn1 ), one of two MRS3/4 orthologues, is essential for erythropoiesis, but little is known about the ubiquitously expressed paralogue mfrn2 . In the present study we identified a single mitoferrin gene ( dmfrn ) in the genome of Drosophila melanogaster , which...
Includes: Supplementary data
Articles
Biochem J (2009) 420 (3): 363–372.
Published: 27 May 2009
... adhesion and activation of TOR (target of rapamycin) signalling. Surprisingly, recent reports suggested that insects lack a membrane-bound CD98hc, but in the present study we show that Drosophila CG2791 encodes a functional CD98hc orthologue with conservation in intracellular, transmembrane and...
Includes: Supplementary data
Articles
Biochem J (2008) 416 (2): 231–241.
Published: 12 November 2008
... remained elusive. In the present study, we address this question using the Drosophila PAK protein Mbt, which is most similar to vertebrate PAK4. Previous phenotypic analysis showed that Mbt has a function to maintain adherens junctions during eye development and indicated a requirement of the protein in...
Includes: Supplementary data
Articles
Biochem J (2008) 414 (1): 63–71.
Published: 29 July 2008
... function in Drosophila appears to be fulfilled by a single gene, futsch . Although the futsch gene product is known to share several important functional properties with mammalian MAP1s, whether it adopts the same basic structural organization has not been addressed. Here, we report the identification of a...
Articles
Biochem J (2006) 400 (1): 91–97.
Published: 27 October 2006
...Cécile Robard; Alex Daviau; Marco Di Fruscio Mutations in the Drosophila kep1 gene, encoding a single maxi KH (K homology) domain-containing RNA-binding protein, result in a reduction of fertility in part due to the disruption of the apoptotic programme during oogenesis. This disruption is...
Includes: Supplementary data
Articles
Biochem J (2006) 399 (1): e1.
Published: 13 September 2006
... unclear. In this issue of the Biochemical Journal , Gallego and colleagues show for the first time that protein phosphatase 1 plays a major role in the stability of mammalian PER2, a key protein in the core clock works. This contrasts somewhat with circadian rhythm control in the fruitfly Drosophila and...
Articles
Biochem J (2006) 398 (3): 451–460.
Published: 29 August 2006
.... 3 To whom correspondence should be addressed (email jyim@snu.ac.kr ). 20 3 2006 9 5 2006 22 5 2006 22 5 2006 The Biochemical Society, London 2006 Drosophila drosopterin eye colour mutant glutathione S-transferase pyrimidodiazepine synthase sepia...
Articles
Biochem J (2006) 396 (1): 127–138.
Published: 26 April 2006
...Takahiro Tanji; Ayako Ohashi-Kobayashi; Shunji Natori A galactose-specific C-type lectin has been purified from a pupal extract of Drosophila melanogaster . This lectin gene, named DL1 ( D rosophila l ectin 1 ), is part of a gene cluster with the other two galactose-specific C-type lectin genes...
Articles
Biochem J (2006) 393 (2): 481–488.
Published: 23 December 2005
...Jonathan P. Day; Miles D. Houslay; Shireen-A. Davies cGMP was first discovered in urine, demonstrating that kidney cells extrude this cyclic nucleotide. Drosophila Malpighian tubules provide a model renal system in which a homologue of mammalian PDE (phosphodiesterase) 6 is expressed. In humans...
Includes: Supplementary data
Articles
Biochem J (2005) 392 (2): 353–362.
Published: 22 November 2005
... is unknown. We show that the proton conductance of muscle mitochondria from mice in which isoform 1 of the adenine nucleotide translocase has been ablated is half that of wild-type controls. Overexpression of the adenine nucleotide translocase encoded by the stress-sensitive B gene in Drosophila...
Articles
Biochem J (2005) 391 (2): 277–284.
Published: 10 October 2005
... enhancement of mitochondrial O 2 •− /H 2 O 2 catabolism would delay age-associated physiological changes and extend the lifespan was tested by simultaneous overexpression of MnSOD (manganese superoxide dismutase) and catalase, ectopically targeted to the mitochondrial matrix of transgenic Drosophila...
Articles
Biochem J (2005) 388 (1): 195–204.
Published: 10 May 2005
...Leonard E. KELLY; A. Marie PHILLIPS The stoned locus of Drosophila produces a dicistronic transcript and encodes two proteins, stoned-A (STNA) and stoned-B (STNB). Both proteins are located at synaptic terminals. The STNB protein contains a domain that has homology with the μ-subunit of the AP...
Articles
Biochem J (2004) 383 (3): 483–490.
Published: 26 October 2004
... the present study, we have studied GSTs and their interaction with components of the JNK pathway from Diptera . We have evaluated the effects of four Delta class Anopheles dirus GSTs, GSTD1-1, GSTD2-2, GSTD3-3 and GSTD4-4, on the activity of full-length recombinant Drosophila HEP (mitogen-activated...
Articles
Biochem J (2004) 383 (2): 303–309.
Published: 08 October 2004
...Adam SOUTHON; Richard BURKE; Melanie NORGATE; Philip BATTERHAM; James CAMAKARIS Copper homoeostasis was investigated in the Drosophila melanogaster S2 cell line to develop an insect model for the study of copper regulation. Real-time PCR studies have demonstrated expression in S2 cells of putative...
Articles
Biochem J (2004) 382 (1): 131–136.
Published: 10 August 2004
... (glutathione, cysteine, Cys-Gly and methionine) and protein mixed disulphides were measured at different ages and ambient temperatures in Drosophila melanogaster . GSH/GSSG ratios decreased significantly with increasing age of the flies, due to an increase in GSSG content. Concentrations of Cys-Gly increased...
Articles
Biochem J (2004) 382 (1): 67–74.
Published: 10 August 2004
... cloned a cDNA (CG17223) from Drosophila melanogaster encoding a protein with homology to mammalian α1,4-glycosyltransferases and expressed it in the yeast Pichia pastoris . Culture supernatants from the transformed yeast were found to display a novel UDP-GalNAc:GalNAcβ1,4GlcNAcβ1-R α- N...
Articles
Biochem J (2004) 379 (2): 283–289.
Published: 15 April 2004
...Marie-Chloé BOULANGER; Tina Branscombe MIRANDA; Steven CLARKE; Marco di FRUSCIO; Beat SUTER; Paul LASKO; Stéphane RICHARD The role of arginine methylation in Drosophila melanogaster is unknown. We identified a family of nine PRMTs (protein arginine methyltransferases) by sequence homology with...
Articles
Biochem J (2004) 378 (3): 763–768.
Published: 15 March 2004
... and Dnmt3b. Owing to their simultaneous presence in mammalian cells, the activities of individual Dnmt have not yet been determined. This includes a fourth putative Dnmt, namely Dnmt2, which has failed to reveal any activity in previous assays. We have now established transgenic Drosophila strains...
Articles
Biochem J (2004) 378 (2): 299–305.
Published: 01 March 2004
...Attila FARKAS; Peter TOMPA; Éva SCHÁD; Rita SINKA; Gáspár JÉKELY; Peter FRIEDRICH Calpain B is one of the two calpain homologues in Drosophila melanogaster that are proteolytically active. We studied its activation by Ca 2+ both in vitro and in vivo , in Schneider (S2) cells. Activation involves...
Articles
Biochem J (2003) 376 (1): 49–60.
Published: 15 November 2003
... essential in mammalian hormone physiology. At present, eleven 17β-HSD isoforms have been defined in mammals, with different tissue-expression and substrate-conversion patterns. We analysed 17β-HSD type 10 (17β-HSD10) from humans and Drosophila , the latter known to be essential in development. In addition...
Articles
Biochem J (2003) 374 (2): 297–306.
Published: 01 September 2003
... (phosphoinositide 3-kinase) activation, generates the lipid second messenger PtdIns(3,4,5) P 3 , which is thought to play a key role in triggering the activation of S6K. Although the major components of the insulin-signalling pathway are conserved in Drosophila , recent studies suggested that S6K activation does...
Articles
Biochem J (2003) 374 (2): 381–391.
Published: 01 September 2003
... family members are involved in regulating key developmental and cellular processes such as neurogenesis, cell proliferation, cytokinesis and cellular differentiation. Two distinct subgroups exist, nuclear and cytosolic. In Drosophila , the founding family member minibrain, whose human orthologue maps to...
Articles
Biochem J (2003) 370 (3): 953–962.
Published: 15 March 2003
...Stephen B. TING; Tomasz WILANOWSKI; Loretta CERRUTI; Lin-Lin ZHAO; John M. CUNNINGHAM; Stephen M. JANE The Drosophila gene grainyhead is the founding member of a large family of genes encoding developmental transcription factors that are highly conserved from fly to human. The family consists of...
Articles
Biochem J (2000) 351 (1): 251–256.
Published: 26 September 2000
...Katarina LUCIAKOVA; Peter BARATH; Ronggui LI; Ahmed ZAID; B. Dean NELSON The human cytochrome c 1 promoter is strongly activated in transfected Drosophila SL2 cells expressing exogenous human E2F1. Transfection-deletion experiments, DNase I protection by E2F1 and gel mobility-shift experiments...
Articles
Biochem J (2000) 345 (3): 725–732.
Published: 25 January 2000
... protein, DmAralar, 69% identical to Aralar1, was found in Drosophila melanogaster , the DMARALAR locus lying on the right arm of the third chromosome, band 99F. The N-terminal half of Aralar2/citrin is able to bind calcium and this requires the presence of the two most distal EF-hands. The localization of...