... a transformative agreement with JISC. cervid CWD Drosophila melanogaster infectivity neurodegeneration prion Prion diseases are fatal transmissible neurodegenerative conditions of mammalian species that include Creutzfeldt–Jakob disease (CJD) of humans, bovine spongiform encephalopathy (BSE...

... with Portland Press and the Biochemical Society under a transformative agreement with JISC. Drosophila melanogaster neurodegeneration prion transcriptomics Protein misfolding neurodegenerative diseases are invariably fatal conditions that include Alzheimer's disease, Huntington's disease...

... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Drosophila melanogaster genetic neurotoxicity prion PrP Sc transmissible Here, we report the successful generation of PrP transgenic Drosophila that provide a novel host system to model genetic human prion...

.... Trichinella mt EF-Tu1 binds to all three types and EF-Tu2 binds only to D-armless Ser-tRNAs, showing an evolutionary intermediate state from canonical EF-Tu to chromadorean nematode (e.g. C. elegans ) EF-Tu species. We report here that two EF-Tu species also participate in Drosophila melanogaster mitochondria...

...-RFP.attP}ZH-51D) fly line were obtained from the Department of Genetics, University of Cambridge, U.K. All fly lines were raised on standard cornmeal media [ 29 ] at 25°C and maintained at low-to-medium density, and pre-mated before experimental use. bioassay Drosophila melanogaster prion...

... acetylation/deacetylation Drosophila melanogaster metabolic regulation notch signalling pathway sirtuins Silent information regulator 1 (Sirt1) is a member of the sirtuin family of protein deacetylases that have long garnered interest for their role in ageing and regulation of metabolism, immune...

...Vladimir Klichko; Barbara H. Sohal; Svetlana N. Radyuk; William C. Orr; Rajindar S. Sohal The phenotypic effects of under- and over-expression of CcO (cytochrome c oxidase) regulatory subunits IV and Vb were examined in Drosophila melanogaster in order to test further the hypothesis...

...Chonticha Saisawang; Jantana Wongsantichon; Albert J. Ketterman The cytosolic GST (glutathione transferase) superfamily has been annotated in the Drosophila melanogaster genome database. Of 36 genes, four undergo alternative splicing to yield a total of 41 GST proteins. In the present study, we...

...Senarath B. P. Athauda; Katsuji Yoshioka; Tadayoshi Shiba; Kenji Takahashi The wild type Copia Gag precursor protein of Drosophila melanogaster expressed in Escherichia coli was shown to be processed autocatalytically to generate two daughter proteins with molecular masses of 33 and 23 kDa on SDS...

... in DDBJ, EMBL, GenBank® and GSDB Nucleotide Sequence Databases under the accession number DQ182329. 29 3 2006 20 4 2006 9 5 2006 9 5 2006 Aedes aegypti alanine glyoxylate aminotransferase Drosophila melanogaster 3-hydroxykynurenine 3-hydroxykynurenine transaminase...

... Hippel-Lindau)-dependent targeting of HIF-1α to the ubiquitin/proteasome pathway. HIF-1α thus accumulates and promotes gene transcription. In the present study, first we provide direct biochemical evidence for the presence of a conserved hypoxic signalling pathway in Drosophila melanogaster . An assay...

... complexes were measured at various ages in mitochondria isolated from thoraces of the fruit fly, Drosophila melanogaster , which consist primarily of flight muscles. The rates of state 3 respiration (ADP-stimulated), RCRs (respiratory control ratios) and uncoupled respiration rates decreased significantly...

...Jonathan P. DAY; Julian A. T. DOW; Miles D. HOUSLAY; Shireen-A. DAVIES Cyclic nucleotide PDEs (phosphodiesterases) are important enzymes that regulate intracellular levels of cAMP and cGMP. In the present study, we identify and characterize novel PDEs in the genetic model, Drosophila melanogaster...

... and peptide hormones. Differences in substrate specificity and subcellular localization of the seven mammalian NEPs contribute to their functional diversity. The sequencing of the Drosophila melanogaster genome has revealed a large expansion of this gene family, resulting in over 20 fly NEP-like genes...

...Josep L. PARRA-PALAU; Gert C. SCHEPER; Daniel E. HARPER; Christopher G. PROUD In Drosophila cells, phosphorylation of eIF4E (eukaryotic initiation factor 4E) is required for growth and development. In Drosophila melanogaster , LK6 is the closest homologue of mammalian Mnk1 and Mnk2 [MAPK (mitogen...

... sufficient purified forms of each enzyme. Our aim was to determine and elucidate the biochemical properties of one such polymerase, pol ζ (DNA polymerase ζ) from Drosophila melanogaster (Dmpol ζ). Using an REV1 (UV-revertible gene 1) protein-affinity column, we have isolated the enzyme directly from...

... 10 10 2003 31 10 2003 31 10 2003 The Biochemical Society, London ©2004 2004 Drosophila melanogaster ecdysone heterodimerization nuclear hormone receptor site-directed mutagenesis yeast two-hybrid analysis Abbreviations used: Ec, ecdysteroid; EcR, Ec receptor...