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Keywords: E-cadherin
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Biochem J (2020) 477 (21): 4313–4326.
Published: 13 November 2020
... α-helices and five β-sheets. Affinity assays indicated that rLRR20 interacts with E-cadherin on the cell surface. Interestingly, its binds to the extracellular (EC) 1 domain in human epithelial (E)-cadherin, which is responsible for binding to another E-cadherin molecule in neighboring cells...
Biochem J (2020) 477 (19): 3803–3818.
Published: 12 October 2020
... role of hTERT SUMOylation in the repression of E-cadherin gene expression and consequent triggering on the epithelial-mesenchymal-transition (EMT) program in breast cancer cells. We also observed that catalytically active CBX4, leads to retention of hTERT/ZEB1 complex onto E-cadherin promoter leading...
Includes: Supplementary data
Biochem J (2017) 474 (8): 1333–1346.
Published: 24 March 2017
... of bladder cancer to an invasive disease. Tumour invasion is often associated with a down-regulation of E-cadherin expression concomitant with a suppression of cell:cell junctions, and decreased levels of E-cadherin expression have been reported in higher grade urothelial bladder tumours. We find...
Includes: Supplementary data
Biochem J (2016) 473 (13): 1929–1940.
Published: 28 June 2016
...-toxin triggers ADAM10’s enzymatic activity, and whether ADAM10 is invariably required for all α-toxin action on cells. In the present study, we show that efficient cleavage of the ADAM10 substrate epithelial cadherin (E-cadherin) requires supra-cytotoxic concentrations of α-toxin, leading to significant...
Includes: Supplementary data
Biochem J (2014) 463 (2): 257–270.
Published: 22 September 2014
... migration. cell motility CRK SH3-binding guanine-nucleotide-releasing protein (C3G) E-cadherin fascin insulin-like growth factor type I receptor (IGF-IR) Rap1 Ras-related human genes RAP1A and RAP1B encode 95% homologous 21 kDa proteins, Rap1A and Rap1B, which share a common 3D...
Includes: Multimedia, Supplementary data
Biochem J (2011) 435 (3): 563–568.
Published: 13 April 2011
...), Gran Via s/n, Km 2.7, l’Hospitalet 08907, Barcelona, Spain 2 To whom correspondence should be addressed (email jbaulida@imim.es ). 8 12 2010 25 2 2011 2 3 2011 2 3 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 E-cadherin epithelial...
Includes: Supplementary data
Biochem J (2006) 394 (2): 449–457.
Published: 10 February 2006
... are repressors that play a central role in the epithelial–mesenchymal transition, a process that occurs during cancer progression. Snail and Slug members are direct repressors of E - cadherin and act by binding to the specific E-boxes of its proximal promoter. In the present study, we demonstrate...
Includes: Supplementary data
Biochem J (2002) 363 (2): 253–262.
Published: 08 April 2002
... that the Tcf-4 transcription factor is subjected exclusively to regulation through the b-catenin}E(epithelial)-cadherin pathway, this implies the specific expression of MMP-26 in cancer cells of epithelial origin. Key words: b-catenin, carcinomas, E-cadherin, epithelial cancer, matrilysin-2, metalloproteinases...