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Keywords: EGFR
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Articles

Activity of EGFR transmembrane region variants indicates specific transmembrane dimers are not required for EGFR activity

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Foteini Bartzoka, Monica Gonzalez-Magaldi, Patrick O. Byrne, Nicole I. Callery, Kalina Hristova, Daniel J. Leahy
Journal: Biochemical Journal
Biochem J (2022) 479 (24): 2465–2475.
https://doi.org/10.1042/BCJ20220472
Published: 19 December 2022
...Foteini Bartzoka; Monica Gonzalez-Magaldi; Patrick O. Byrne; Nicole I. Callery; Kalina Hristova; Daniel J. Leahy The Epidermal Growth Factor Receptor (EGFR) is a Receptor Tyrosine Kinase that mediates cell proliferation and differentiation events during development and maintenance of complex...
View articletitled, Activity of EGFR transmembrane region variants indicates specific transmembrane dimers are not required for EGFR activity
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Includes: Supplementary data
Articles

The sequence Pro 295 –Thr 311 of the hinge region of oestrogen receptor α is involved in ERK1/2 activation via GPR30 in leiomyoma cells

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Denis Leiber, Fabienne Burlina, Cillian Byrne, Philippe Robin, Christophe Piesse, Lucie Gonzalez, Guy Leclercq, Zahra Tanfin, Yves Jacquot
Journal: Biochemical Journal
Biochem J (2015) 472 (1): 97–109.
https://doi.org/10.1042/BJ20150744
Published: 30 October 2015
.... In the present study, we investigated its effects in ELT3 leiomyoma cells under similar conditions. We show that it activates ERK1/2 (extracellular-signal-regulated kinase 1/2), the Gα i protein, the trans -activation of EGFR (epidermal growth factor receptor) and, finally, cell proliferation. It is partially...
View articletitled, The sequence Pro 295 –Thr 311 of the hinge region of oestrogen receptor α is involved in ERK1/2 activation via GPR30 in leiomyoma cells
Open the PDF for The sequence Pro 295 –Thr 311 of the hinge region of oestrogen receptor α is involved in ERK1/2 activation via GPR30 in leiomyoma cells in another window
Articles

Unravelling the pivotal role of Alix in MVB sorting and silencing of the activated EGFR

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Sheng Sun, Xi Zhou, Wei Zhang, Gary E. Gallick, Jian Kuang
Journal: Biochemical Journal
Biochem J (2015) 466 (3): 475–487.
https://doi.org/10.1042/BJ20141156
Published: 06 March 2015
... for degradation of these receptors in lysosomes. The adaptor protein Alix is critically involved in multiple ESCRT-III-mediated, membrane-remodelling processes in mammalian cells. However, Alix knockdown does not inhibit degradation of the activated epidermal growth factor receptor (EGFR) in mammalian cell lines...
View articletitled, Unravelling the pivotal role of Alix in MVB sorting and silencing of the activated EGFR
Open the PDF for Unravelling the pivotal role of Alix in MVB sorting and silencing of the activated EGFR in another window
Includes: Supplementary data