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Keywords: ER stress
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Biochem J (2021) 478 (10): 1861–1877.
Published: 18 May 2021
... Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 ceramides ER stress fatty acid transport protein 4 lipidomics polarized macrophages triacylglycerides Macrophages are generated in the bone marrows and mononuclear phagocytes in circulation under...
Includes: Supplementary data
Biochem J (2021) 478 (6): 1261–1282.
Published: 19 March 2021
... hIAPP did not have any adverse effect on the proliferation of β-cells nor did it affect nucleolar organization or function. However, intact nucleolar organization and function were essential for hIAPP expression under normal and ER-stress conditions as RNA polymerase II inhibitor, α-amanitin, reduced...
Includes: Multimedia, Supplementary data
Biochem J (2018) 475 (5): 923–929.
Published: 09 March 2018
...Stanley M.H. Chan; Mark P. Lowe; Ashton Bernard; Alyson A. Miller; Terence P. Herbert Inositol-requiring enzyme 1 alpha (IRE1α) is an endoplasmic reticulum (ER)-transmembrane endonuclease that is activated in response to ER stress as part of the unfolded protein response (UPR). Chronic activation...
Biochem J (2017) 474 (1): 51–63.
Published: 22 December 2016
... signaling mostly proceeds outside ER–PM contact sites in the PM and did not require intact ER–PM contact for its activation. Rather, the Rim101 pathway was constitutively activated by ER–PM contact site disruption, which is known to cause ER stress. ER stress induced by tunicamycin treatment activated the...
Biochem J (2016) 473 (4): 423–434.
Published: 09 February 2016
... UPR, albeit with different intensities and timing profiles that partially correlate with the degree of misfolding caused by each mutation on NLGN3. We show that all three ER stress sensors, ATF6, IRE1 and PERK, are activated by the mutant R451C NLGN3 protein, eliciting the corresponding signalling...
Includes: Supplementary data
Biochem J (2015) 468 (1): 33–47.
Published: 05 May 2015
...-oligomeric equilibrium. Finally, overexpression of protein phosphatases Ptc2 and Ptc3 alleviated the growth defect of reg1 cells under endoplasmic reticulum (ER) stress conditions. Altogether, our results reveal that Snf1 plays an important role in the attenuation of the UPR, as well as identifying the...
Includes: Supplementary data
Biochem J (2015) 466 (1): 115–121.
Published: 06 February 2015
... in the liver. In the present study, we address the role played by CREBH activated by ER stress in HBV-induced hepatic cell proliferation. We confirmed CREBH activation by ER stress and showed that it occurred as a result of/via hepatitis B virus X (HBx)-induced ER stress. CREBH activated by HBx...
Biochem J (2000) 346 (2): 281–293.
Published: 22 February 2000
... identified and characterized PEK homologues from humans, Drosophila melanogaster and Caenorhabditis elegans . Expression of human PEK mRNA was found in over 50 different tissues examined, with highest levels in secretory tissues. In mammalian cells subjected to ER stress, we found that elevated eIF-2α...