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Keywords: FTY720
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Articles
Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins
Available to PurchaseKimberly Romero Rosales, Gurpreet Singh, Kevin Wu, Jie Chen, Matthew R. Janes, Michael B. Lilly, Eigen R. Peralta, Leah J. Siskind, Michael J. Bennett, David A. Fruman, Aimee L. Edinger
Journal:
Biochemical Journal
Biochem J (2011) 439 (2): 299–311.
Published: 28 September 2011
... in autophagy, the catabolic process that provides nutrients from internal sources when external nutrients are unavailable. Normal cells, in contrast, can adapt to the nutrient stress that kills cancer cells by becoming quiescent and catabolic. In the present study we show that FTY720, a water-soluble...
Includes: Supplementary data
