...Tilen Koklic; Rima Chattopadhyay; Rinku Majumder; Barry R. Lentz Factor Va competes factor Xa off of inactive factor Xa dimers to amplify thrombin production, both because it releases dimer inhibition and because of its cofactor activity. This suggests an unanticipated mechanism by which platelet...

... coagulation, commonly thought to be due to insufficient functioning of anticoagulation pathways. A small amount of fXa (Factor Xa) produced by Factor VIIa and exposed tissue factor is key to initiating blood coagulation by producing enough thrombin to induce the later stages of coagulation. fXa must bind...

...Kinshuk Raj Srivasatava; Rinku Majumder; William H. Kane; Mary Ann Quinn-Allen; Barry R. Lentz Human coagulation FXa (Factor Xa) plays a key role in blood coagulation by activating prothrombin to thrombin on ‘stimulated’ platelet membranes in the presence of its cofactor FVa (Factor Va). PS...

... (activated Factor Xa) and its N-terminal EGF deletion mutant (fXa-desEGF1), and the acceptor OR (octadecylrhodamine) dye incorporated into phospholipid vesicles composed of 80% phosphatidylcholine and 20% phosphatidylserine. The average distance of closest approach ( L ) between fluorescein in the active...

..., MD 20892–8132, U.S.A. (email [email protected] ). 13 10 2004 1 12 2004 23 12 2004 23 12 2004 The Biochemical Society, London 2005 blood feeding Factor Xa heparin-binding exosite prothrombin tick saliva FXa (Factor Xa) is a vitamin K-dependent...

...Abed R. ZEIBDAWI; Jean E. GRUNDY; Bogna LASIA; Edward L. G. PRYZDIAL Coagulation FVa (factor Va) accelerates the essential generation of thrombin by FXa (factor Xa). Although the noncovalent Ca 2+ -dependent association between the FVa light and heavy subunits (FVaL and FVaH) is required...