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Keywords: G-protein
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Articles

A structure model explaining the binding between a ubiquitous unconventional G-protein (OsYchF1) and a plant-specific C2-domain protein (OsGAP1) from rice

Ming-Yan Cheung, Jacky Chi-Ki Ngo, Zhongzhou Chen, Qi Jia, Tianjie Li, Yitao Gou, Yi Wang, Hon-Ming Lam
Journal: Biochemical Journal
Biochem J (2020) 477 (20): 3935–3949.
https://doi.org/10.1042/BCJ20200380
Published: 23 October 2020
...Ming-Yan Cheung; Jacky Chi-Ki Ngo; Zhongzhou Chen; Qi Jia; Tianjie Li; Yitao Gou; Yi Wang; Hon-Ming Lam The unconventional G-protein OsYchF1 plays regulatory roles in plant defense and abiotic stress responses. We have previously resolved the crystal structures of OsYchF1 and its plant-specific...
View articletitled, A structure model explaining the binding between a ubiquitous unconventional G-protein (OsYchF1) and a plant-specific C2-domain protein (OsGAP1) from rice
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Includes: Supplementary data
Articles

AZD8797 is an allosteric non-competitive modulator of the human CX3CR1 receptor

Linda Cederblad, Birgitta Rosengren, Erik Ryberg, Nils-Olov Hermansson
Journal: Biochemical Journal
Biochem J (2016) 473 (5): 641–649.
https://doi.org/10.1042/BJ20150520
Published: 24 February 2016
...) and in a B-lymphocyte cell line with IC 50 values of 300 and 6 nM respectively. AZD8797 also prevented G-protein activation in a [ 35 S]GTPγS (guanosine 5′-[γ-thio]triphosphate) accumulation assay. In contrast, dynamic mass redistribution (DMR) experiments revealed a weak G αi -dependent AZD8797 agonism...
View articletitled, AZD8797 is an allosteric non-competitive modulator of the human CX3CR1 receptor
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Articles

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity

Aliaksei Shymanets, Prajwal, Oscar Vadas, Cornelia Czupalla, Jaclyn LoPiccolo, Michael Brenowitz, Alessandra Ghigo, Emilio Hirsch, Eberhard Krause, Reinhard Wetzker, Roger L. Williams, Christian Harteneck, Bernd Nürnberg
Journal: Biochemical Journal
Biochem J (2015) 469 (1): 59–69.
https://doi.org/10.1042/BJ20150099
Published: 19 June 2015
... enzymes downstream of signalling cascades triggered by G-protein-coupled receptors (GPCRs). PI3Kγ variants have one catalytic p110γ subunit that can form two different heterodimers by binding to one of a pair of non-catalytic subunits, p87 or p101. Growing experimental data argue for a different...
View articletitled, Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity
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Articles

The p101 subunit of PI3Kγ restores activation by Gβ mutants deficient in stimulating p110γ

Aliaksei Shymanets, Mohammad R. Ahmadian, Katja T. Kössmeier, Reinhard Wetzker, Christian Harteneck, Bernd Nürnberg
Journal: Biochemical Journal
Biochem J (2012) 441 (3): 851–858.
https://doi.org/10.1042/BJ20111664
Published: 16 January 2012
...Aliaksei Shymanets; Mohammad R. Ahmadian; Katja T. Kössmeier; Reinhard Wetzker; Christian Harteneck; Bernd Nürnberg G-protein-regulated PI3Kγ (phosphoinositide 3-kinase γ) plays a crucial role in inflammatory and allergic processes. PI3Kγ, a dimeric protein formed by the non-catalytic p101...
View articletitled, The p101 subunit of PI3Kγ restores activation by Gβ mutants deficient in stimulating p110γ
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Articles

Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33

Mislav Oreb, Anja Höfle, Patrick Koenig, Maik S. Sommer, Irmgard Sinning, Fei Wang, Ivo Tews, Danny J. Schnell, Enrico Schleiff
Journal: Biochemical Journal
Biochem J (2011) 436 (2): 313–319.
https://doi.org/10.1042/BJ20110246
Published: 13 May 2011
..., Goethe University Frankfurt, D-60438 Frankfurt am Main, Germany. dimeric GTPase GDP-dissociation-inhibitor function (GDI function) G-protein protein translocation substrate-based regulation In eukaryotic cells, protein targeting and translocation are highly ordered and regulated...
View articletitled, Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33
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Articles

Wnt signalling: the case of the ‘missing’ G-protein

Craig C. Malbon
Journal: Biochemical Journal
Biochem J (2011) 433 (3): e3–e5.
https://doi.org/10.1042/BJ20102111
Published: 14 January 2011
...Craig C. Malbon Wnt signalling remains a hot topic for cell signalling sleuthhounds. The trail of signalling downstream of the seven-transmembrane segment Frizzleds, which bind Wnt ligands, is replete of clues [e.g. LPR5/6 (lipoprotein receptor-related protein 5/6), G-proteins or Dishevelled...
View articletitled, Wnt signalling: the case of the ‘missing’ G-protein
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Articles

The vasoactive peptides urotensin II and urotensin II-related peptide regulate astrocyte activity through common and distinct mechanisms: involvement in cell proliferation

Marie Jarry, Mickaël Diallo, Céline Lecointre, Laurence Desrues, Tursonjan Tokay, David Chatenet, Jérôme Leprince, Oriana Rossi, Hubert Vaudry, Marie-Christine Tonon, Laurent Prézeau, Hélène Castel, Pierrick Gandolfo
Journal: Biochemical Journal
Biochem J (2010) 428 (1): 113–124.
https://doi.org/10.1042/BJ20090867
Published: 28 April 2010
... energy transfer calcium cell proliferation G-protein urotensin II receptor URP (A CFWKYC V), rat UII (UII, p QHGTAPE CFWKYC I) ( p Q, pyroglutamic acid; underlining indicates the conserved hexapeptide core) and rat ODN DBI 33–50 were synthesized using the solid-phase methodology on a Pioneer...
View articletitled, The vasoactive peptides urotensin II and urotensin II-related peptide regulate astrocyte activity through common and distinct mechanisms: involvement in cell proliferation
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Articles

Interaction of retinal guanylate cyclase with the α subunit of transducin: potential role in transducin localization

Derek H. Rosenzweig, K. Saidas Nair, Konstantin Levay, Igor V. Peshenko, John W. Crabb, Alexander M. Dizhoor, Vladlen Z. Slepak
Journal: Biochemical Journal
Biochem J (2009) 417 (3): 803–812.
https://doi.org/10.1042/BJ20081513
Published: 16 January 2009
... hydrolysis via the G-protein transducin, which directly binds to and activates phosphodiesterase. Bright light also causes relocalization of transducin from the OS (outer segments) of the rod cells to the inner compartments. In the present study, we show experimental evidence for a previously unknown...
View articletitled, Interaction of retinal guanylate cyclase with the α subunit of transducin: potential role in transducin localization
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Includes: Supplementary data
Articles

Pathways of signal transduction employed by vertebrate Hedgehogs

Natalia A. Riobo, David R. Manning
Journal: Biochemical Journal
Biochem J (2007) 403 (3): 369–379.
https://doi.org/10.1042/BJ20061723
Published: 12 April 2007
...-proteins and G-protein-coupled receptor kinases by Smoothened. We also address the pathways, insofar as known, linking Smoothened to the expression and stability of Gli1, Gli2 and Gli3. The mechanisms by which Hh proteins signal have few, if any, parallels. It is becoming clear in vertebrates, however...
View articletitled, Pathways of signal transduction employed by vertebrate Hedgehogs
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Articles

Big roles for small GTPases in the control of directed cell movement

Pascale G. Charest, Richard A. Firtel
Journal: Biochemical Journal
Biochem J (2007) 401 (2): 377–390.
https://doi.org/10.1042/BJ20061432
Published: 21 December 2006
... shed light on the molecular mechanisms by which small GTPases control directed cell migration. cell polarity cellular motility directional sensing eukaryotic chemotaxis G-protein The migration of neutrophils to sites of inflammation, the organization of embryonic cells during morphogenesis...
View articletitled, Big roles for small GTPases in the control of directed cell movement
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Articles

Regulation of the cardiac L-type calcium channel in L6 cells by arginine-vasopressin

Basil M. Hantash, Andrew P. Thomas, John P. Reeves
Journal: Biochemical Journal
Biochem J (2006) 400 (3): 411–419.
https://doi.org/10.1042/BJ20060742
Published: 28 November 2006
.... (email [email protected] ). 18 5 2006 26 7 2006 16 8 2006 16 8 2006 The Biochemical Society, London 2006 arginine-vasopressin (AVP) cardiac L-type calcium channel G-protein L6 cell protein kinase C (PKC) The voltage-dependent Ca 2+ channels of the long...
View articletitled, Regulation of the cardiac L-type calcium channel in L6 cells by arginine-vasopressin
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Articles

Rapid stimulation of tyrosine phosphorylation signals downstream of G-protein-coupled receptors for thromboxane A 2 in human platelets

Pietro Minuz, Laura Fumagalli, Stefania Gaino, Rosa M. Tommasoli, Maurizio Degan, Chiara Cavallini, Anna Lecchi, Marco Cattaneo, Clara Lechi Santonastaso, Giorgio Berton
Journal: Biochemical Journal
Biochem J (2006) 400 (1): 127–134.
https://doi.org/10.1042/BJ20061015
Published: 27 October 2006
...Pietro Minuz; Laura Fumagalli; Stefania Gaino; Rosa M. Tommasoli; Maurizio Degan; Chiara Cavallini; Anna Lecchi; Marco Cattaneo; Clara Lechi Santonastaso; Giorgio Berton Signals ensuing from trimeric G-protein-coupled receptors synergize to induce platelet activation. At low doses, the thromboxane...
View articletitled, Rapid stimulation of tyrosine phosphorylation signals downstream of G-protein-coupled receptors for thromboxane A 2 in human platelets
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Articles

The allosteric enhancer PD81,723 increases chimaeric A 1 /A 2A adenosine receptor coupling with G s

Samita Bhattacharya, Rebecca L. Youkey, Kobina Ghartey, Matthew Leonard, Joel Linden, Amy L. Tucker
Journal: Biochemical Journal
Biochem J (2006) 396 (1): 139–146.
https://doi.org/10.1042/BJ20051422
Published: 26 April 2006
... -coupled A 2A ARs. PD81,723 elicits a decrease in the dissociation kinetics of A 1 AR agonist radioligands and an increase in functional agonist potency. In the present study, we sought to determine whether enhancer sensitivity is dependent on coupling domains or G-protein specificity of the A 1 AR. Using...
View articletitled, The allosteric enhancer PD81,723 increases chimaeric A 1 /A 2A adenosine receptor coupling with G s
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Articles

New insights into the families of PLC enzymes: looking back and going forward

Matilda Katan
Journal: Biochemical Journal
Biochem J (2005) 391 (3): e7.
https://doi.org/10.1042/BJ20051506
Published: 25 October 2005
... (phosphoinositide-specific phospholipase C) enzymes, PLCη. Two isoforms, PLCη1 and PLCη2, and their splice variants add to the molecular diversity of PLC enzymes. The studies of PLCη regulation suggest that at least some splice variants of PLCη2 could be regulated by the G-protein subunits Gβγ. As two other...
View articletitled, New insights into the families of PLC enzymes: looking back and going forward
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Articles

Molecular cloning and characterization of PLC-η2

Yixing Zhou, Michele R. Wing, John Sondek, T. Kendall Harden
Journal: Biochemical Journal
Biochem J (2005) 391 (3): 667–676.
https://doi.org/10.1042/BJ20050839
Published: 25 October 2005
... spliced first exons. Co-expression of PLC-η2 with Gβ 1 γ 2 dimers of heterotrimeric G-proteins resulted in marked stimulation of inositol lipid hydrolysis. Thus PLC-η2 may in part function downstream of G-protein-coupled receptors. 20 5 2005 2 8 2005 18 8 2005 18 8 2005...
View articletitled, Molecular cloning and characterization of PLC-η2
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Articles

Phosphatidylinositol 3,4,5-trisphosphate and Ca 2+ /calmodulin competitively bind to the regulators of G-protein-signalling (RGS) domain of RGS4 and reciprocally regulate its action

Masaru ISHII, Satoru FUJITA, Mitsuhiko YAMADA, Yukio HOSAKA, Yoshihisa KURACHI
Journal: Biochemical Journal
Biochem J (2005) 385 (1): 65–73.
https://doi.org/10.1042/BJ20040404
Published: 14 December 2004
...Masaru ISHII; Satoru FUJITA; Mitsuhiko YAMADA; Yukio HOSAKA; Yoshihisa KURACHI RGS (regulators of G-protein signalling) are a diverse group of proteins, which accelerate intrinsic GTP hydrolysis on heterotrimeric G-protein α subunits. They are involved in the control of a physiological behaviour...
View articletitled, Phosphatidylinositol 3,4,5-trisphosphate and Ca 2+ /calmodulin competitively bind to the regulators of G-protein-signalling (RGS) domain of RGS4 and reciprocally regulate its action
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Articles

Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1

Ian N. FLEMING, Ian H. BATTY, Alan R. PRESCOTT, Alex GRAY, Gursant S. KULAR, Hazel STEWART, C. Peter DOWNES
Journal: Biochemical Journal
Biochem J (2004) 382 (3): 857–865.
https://doi.org/10.1042/BJ20040916
Published: 07 September 2004
[email protected] ). 1 6 2004 2 7 2004 9 7 2004 9 7 2004 The Biochemical Society, London 2004 G-protein guanine-nucleotide-exchange factor inositol phospholipid pleckstrin homology domain Rac1 Tiam1 PH (pleckstrin homology) domains are poorly conserved protein modules...
View articletitled, Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1
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Articles

Ligand-dependent autophosphorylation of the insulin receptor is positively regulated by Gi-proteins

J. KREUZER, B. NÜRNBERG, H. I. KRIEGER-BRAUER
Journal: Biochemical Journal
Biochem J (2004) 380 (3): 831–836.
https://doi.org/10.1042/bj20031659
Published: 15 June 2004
... function. For the experiments, isolated IRs from plasma membranes of human fat cells were used. The activation of IR autophosphorylation by insulin was blocked by G-protein inactivation through GDPβS (guanosine 5´-[β-thio]disphosphate). Consistently, activation of G-proteins by micromolar concentrations...
View articletitled, Ligand-dependent autophosphorylation of the insulin receptor is positively regulated by Gi-proteins
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Includes: Supplementary data
Articles

Identification of a stretch of six divergent amino acids on the alpha5 helix of Galpha16 as a major determinant of the promiscuity and efficiency of receptor coupling

Maurice K. C. HO, Jasmine H. P. CHAN, Cecilia S. S. WONG, Yung H. WONG
Journal: Biochemical Journal
Biochem J (2004) 380 (2): 361–369.
https://doi.org/10.1042/bj20040231
Published: 01 June 2004
...Maurice K. C. HO; Jasmine H. P. CHAN; Cecilia S. S. WONG; Yung H. WONG A broad repertory of G-protein-coupled receptors shows effective coupling with the haematopoietic G 16 protein. In the present study, individual residues along the C-terminal α5 helix of Gα 16 were examined...
View articletitled, Identification of a stretch of six divergent amino acids on the alpha5 helix of Galpha16 as a major determinant of the promiscuity and efficiency of receptor coupling
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Articles

Mutation of cysteine 214 in Gi1 alpha subunit abolishes its endogenous GTPase activity

Yuren WANG, Gregory TAWA, Deborah SMITH, Girija KRISHNAMURTHY, Kathleen H. YOUNG
Journal: Biochemical Journal
Biochem J (2004) 379 (3): 673–679.
https://doi.org/10.1042/bj20031343
Published: 01 May 2004
...-mail [email protected] ). 3 9 2003 5 1 2004 16 1 2004 16 1 2004 The Biochemical Society, London ©2004 2004 cysteine G-protein GTPase GTP hydrolysis site-directed mutagenesis Abbreviations used: GST, glutathione S-transferase; CHO, Chinese hamster ovary; GTP[S...
View articletitled, Mutation of cysteine 214 in Gi1 alpha subunit abolishes its endogenous GTPase activity
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Articles

Purification and biochemical characterization of the D6 chemokine receptor

Paul E. BLACKBURN, Clare V. SIMPSON, Robert J. B. NIBBS, Maureen O'HARA, Rhona BOOTH, Jemma POULOS, Neil W. ISAACS, Gerard J. GRAHAM
Journal: Biochemical Journal
Biochem J (2004) 379 (2): 263–272.
https://doi.org/10.1042/bj20031266
Published: 15 April 2004
... should be addressed (e-mail [email protected] or [email protected] ). 19 8 2003 23 12 2003 15 1 2004 15 1 2004 The Biochemical Society, London ©2004 2004 chemokine D6 chemokine receptor G-protein purification structure Abbreviations used: CHS...
View articletitled, Purification and biochemical characterization of the D6 chemokine receptor
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Articles

Role of receptor tyrosine kinases in G-protein-coupled receptor regulation of Ras: transactivation or parallel pathways?

Julian DOWNWARD
Journal: Biochemical Journal
Biochem J (2003) 376 (1): e9–e10.
https://doi.org/10.1042/bj20031745
Published: 15 November 2003
...Julian DOWNWARD Ras protein regulation by G-protein-coupled receptors has been thought to occur through transactivation of receptor tyrosine kinases. New evidence suggests that these two receptor types independently control different pathways leading to Ras activation in response...
View articletitled, Role of receptor tyrosine kinases in G-protein-coupled receptor regulation of Ras: transactivation or parallel pathways?
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Articles

Co-incident signalling between μ-opioid and M3 muscarinic receptors at the level of Ca2+ release from intracellular stores: lack of evidence for Ins(1,4,5)P3 receptor sensitization

Damien S. K. SAMWAYS, Wen-hong LI, Stuart J. CONWAY, Andrew B. HOLMES, Martin D. BOOTMAN, Graeme HENDERSON
Journal: Biochemical Journal
Biochem J (2003) 375 (3): 713–720.
https://doi.org/10.1042/bj20030508
Published: 01 November 2003
... 2003 24 7 2003 25 7 2003 25 7 2003 The Biochemical Society, London ©2003 2003 Ca 2+ G-protein Ins P 3 μ-opioid Abbreviations used: AM, acetoxymethyl ester; [Ca 2+ ] i , intracellular free-Ca 2+ concentration; Ins P 3 , Ins(1,4,5) P 3 ; ciIns P 3 /PM, caged...
View articletitled, Co-incident signalling between μ-opioid and M3 muscarinic receptors at the level of Ca2+ release from intracellular stores: lack of evidence for Ins(1,4,5)P3 receptor sensitization
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Articles

Regulation and organization of adenylyl cyclases and cAMP

Dermot M. F. COOPER
Journal: Biochemical Journal
Biochem J (2003) 375 (3): 517–529.
https://doi.org/10.1042/bj20031061
Published: 01 November 2003
... dynamics may differ from the broad cytosol. Currently evolving methodologies are beginning to reveal cAMP fluctuations in these various compartments. Key words: adenylyl cyclase, calcium, cAMP, G-protein, protein kinase A (PKA), raft. INTRODUCTION The ubiquity of cAMP signalling in nature is associated...
View articletitled, Regulation and organization of adenylyl cyclases and cAMP
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Articles

Activation of phosphoinositide 3-kinase by D2 receptor prevents apoptosis in dopaminergic cell lines

Venugopalan D. NAIR, C. Warren OLANOW, Stuart C. SEALFON
Journal: Biochemical Journal
Biochem J (2003) 373 (1): 25–32.
https://doi.org/10.1042/bj20030017
Published: 01 July 2003
... do not express detectable D 2 receptors. Notably, the agonists studied differ in their relative efficacy to mediate anti-apoptotic effects and in their capacity to stimulate [ 35 S]guanosine 5′-[γ-thio]triphosphate ([ 35 S]GTP[S]) binding, an indicator of G-protein activation. Studies with inhibitors...
View articletitled, Activation of phosphoinositide 3-kinase by D2 receptor prevents apoptosis in dopaminergic cell lines
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Articles

RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain

Jiaxin NIU, Astrid SCHESCHONKA, Kirk M. DRUEY, Amanda DAVIS, Eleanor REED, Vladimir KOLENKO, Richard BODNAR, Tatyana VOYNO-YASENETSKAYA, Xiaoping DU, John KEHRL, Nickolai O. DULIN
Journal: Biochemical Journal
Biochem J (2002) 365 (3): 677–684.
https://doi.org/10.1042/bj20020390
Published: 01 August 2002
...Jiaxin NIU; Astrid SCHESCHONKA; Kirk M. DRUEY; Amanda DAVIS; Eleanor REED; Vladimir KOLENKO; Richard BODNAR; Tatyana VOYNO-YASENETSKAYA; Xiaoping DU; John KEHRL; Nickolai O. DULIN RGS3 belongs to a family of the regulators of G-protein signalling (RGS), which bind and inhibit the Gα subunits...
View articletitled, RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain
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Articles

Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences

Douglas RAMSAY, Elaine KELLETT, Mary McVEY, Stephen REES, Graeme MILLIGAN
Journal: Biochemical Journal
Biochem J (2002) 365 (2): 429–440.
https://doi.org/10.1042/bj20020251
Published: 15 July 2002
...Douglas RAMSAY; Elaine KELLETT; Mary McVEY; Stephen REES; Graeme MILLIGAN Homo- and hetero-oligomerization of G-protein-coupled receptors (GPCRs) were examined in HEK-293 cells using two variants of bioluminescence resonance energy transfer (BRET). BRET 2 (a variant of BRET) offers greatly improved...
View articletitled, Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences
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Articles

Suramin and the suramin analogue NF307 discriminate among calmodulin-binding sites

Markus KLINGER, Elisa BOFILL-CARDONA, Bernd MAYER, Christian NANOFF, Michael FREISSMUTH, Martin HOHENEGGER
Journal: Biochemical Journal
Biochem J (2001) 355 (3): 827–833.
https://doi.org/10.1042/bj3550827
Published: 24 April 2001
... were purified [ryanodine receptor-1 (RyR1) from rabbit skeletal muscle, neuronal NO synthase (nNOS) from Sf9 cells, G-protein βγ dimers (Gβγ) from porcine brain and a glutathione S-transferase-fusion protein comprising the C-terminal calmodulin-binding domain of the metabotropic glutamate receptor 7A...
View articletitled, Suramin and the suramin analogue NF307 discriminate among calmodulin-binding sites
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Articles

Peptide YY Y1 receptor activates mitogen-activated protein kinase and proliferation in gut epithelial cells via the epidermal growth factor receptor

Peter J. MANNON, Jennifer M. MELE
Journal: Biochemical Journal
Biochem J (2000) 350 (3): 655–661.
https://doi.org/10.1042/bj3500655
Published: 08 September 2000
...Peter J. MANNON; Jennifer M. MELE The G-protein-coupled peptide YY (PYY)/neuropeptide Y Y1 receptor (Y1R) subtype is highly expressed in the proliferative zone of human colonic crypt epithelial cells but biochemical and biological support for growth effects have been lacking. Using a model gut...
View articletitled, Peptide YY Y1 receptor activates mitogen-activated protein kinase and proliferation in gut epithelial cells via the epidermal growth factor receptor
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Articles

Palmitoylation of the recombinant human A1 adenosine receptor: enhanced proteolysis of palmitoylation-deficient mutant receptors

Zhenhai GAO, Yajun NI, Gabor SZABO, Joel LINDEN
Journal: Biochemical Journal
Biochem J (1999) 342 (2): 387–395.
https://doi.org/10.1042/bj3420387
Published: 24 August 1999
...), down-regulation (24 h), inhibition of forskolin-stimulated cAMP accumulation, or activation of co-transfected G-protein-activated inward rectifier K + /cardiac inward rectifying K + (GIRK1/CIR K + ) channels. Also unaffected by palmitoylation is guanosine 5′-[γ-thio]-triphosphate ([S]GTP)-sensitive...
View articletitled, Palmitoylation of the recombinant human A1 adenosine receptor: enhanced proteolysis of palmitoylation-deficient mutant receptors
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