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Keywords: G-protein-coupled receptor
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Articles

Dynamic conformational switching in the chemokine ligand is essential for G-protein-coupled receptor activation

Prem Raj B. Joseph, Kirti V. Sawant, Angela Isley, Mesias Pedroza, Roberto P. Garofalo, Ricardo M. Richardson, Krishna Rajarathnam
Journal: Biochemical Journal
Biochem J (2013) 456 (2): 241–251.
https://doi.org/10.1042/BJ20130148
Published: 08 November 2013
...Prem Raj B. Joseph; Kirti V. Sawant; Angela Isley; Mesias Pedroza; Roberto P. Garofalo; Ricardo M. Richardson; Krishna Rajarathnam Chemokines mediate diverse functions from organogenesis to mobilizing leucocytes, and are unusual agonists for class-A GPCRs (G-protein-coupled receptors) because...
View article titled, Dynamic conformational switching in the chemokine ligand is essential for <span class="search-highlight">G</span>-<span class="search-highlight">protein</span>-<span class="search-highlight">coupled</span> <span class="search-highlight">receptor</span> activation
Open the PDF for Dynamic conformational switching in the chemokine ligand is essential for <span class="search-highlight">G</span>-<span class="search-highlight">protein</span>-<span class="search-highlight">coupled</span> <span class="search-highlight">receptor</span> activation in another window
Articles

The Arf GAP AGAP2 interacts with β-arrestin2 and regulates β 2 -adrenergic receptor recycling and ERK activation

Yuanjun Wu, Yu Zhao, Xiaojie Ma, Yunjuan Zhu, Jaimin Patel, Zhongzhen Nie
Journal: Biochemical Journal
Biochem J (2013) 452 (3): 411–421.
https://doi.org/10.1042/BJ20121004
Published: 31 May 2013
... ). 21 6 2012 7 3 2013 26 3 2013 26 3 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 AGAP2 β-arrestin2 Arf GTPase-activating protein endocytosis G-protein-coupled receptor recycling endosome β 2 ARs (β 2 -adrenergic receptors) are members...
View article titled, The Arf GAP AGAP2 interacts with β-arrestin2 and regulates β 2 -adrenergic receptor recycling and ERK activation
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Articles

A 2A adenosine receptor ligand binding and signalling is allosterically modulated by adenosine deaminase

Eduard Gracia, Kamil Pérez-Capote, Estefanía Moreno, Jana Barkešová, Josefa Mallol, Carme Lluís, Rafael Franco, Antoni Cortés, Vicent Casadó, Enric I. Canela
Journal: Biochemical Journal
Biochem J (2011) 435 (3): 701–709.
https://doi.org/10.1042/BJ20101749
Published: 13 April 2011
... adenosine deaminase adenosine receptor allosteric interaction G-protein-coupled receptor protein–protein interaction receptor binding parameter Self-association of proteins to form dimers and higher-order oligomers and/or interaction with other proteins are key factors in cell signalling [ 1...
View article titled, A 2A adenosine receptor ligand binding and signalling is allosterically modulated by adenosine deaminase
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Articles

Wnt signalling: the case of the ‘missing’ G-protein

Craig C. Malbon
Journal: Biochemical Journal
Biochem J (2011) 433 (3): e3–e5.
https://doi.org/10.1042/BJ20102111
Published: 14 January 2011
...] and yet remains the ‘final problem’. Although the heptahelical nature of Frizzleds places them well within a populous family of G-protein-coupled receptors, resistance to this theme has waxed and waned amid increasing demands for ‘proof’. The Wnt Homepage ( http://www.stanford.edu/group/nusselab/cgi-bin...
View article titled, Wnt signalling: the case of the ‘missing’ G-protein
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Articles

Lysophosphatidylcholines activate G2A inducing G αi-1 -/G αq/11 - Ca 2+ flux, G βγ -Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNs

Samina Y. Khan, Nathan J. D. McLaughlin, Marguerite R. Kelher, Phillip Eckels, Fabia Gamboni-Robertson, Anirban Banerjee, Christopher C. Silliman
Journal: Biochemical Journal
Biochem J (2010) 432 (1): 35–45.
https://doi.org/10.1042/BJ20091087
Published: 25 October 2010
... of infection/inflammation to eradicate pathogens and to promote tissue healing [ 1 – 5 ]. These GPCRs (G-protein-coupled receptors) are linked to a number of regulatory proteins that allow for ligand activation resulting in signal transduction and receptor desensitization [ 2 , 4 , 5 ]. Important...
View article titled, Lysophosphatidylcholines activate G2A inducing G αi-1 -/G αq/11 - Ca 2+ flux, G βγ -Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNs
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Articles

CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2–DOP receptor heterodimer

Geraldine Parenty, Shirley Appelbe, Graeme Milligan
Journal: Biochemical Journal
Biochem J (2008) 412 (2): 245–256.
https://doi.org/10.1042/BJ20071689
Published: 14 May 2008
...-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. allosterism chemokine G-protein-coupled receptor heterodimer opioid where A 665 is the fluorescent emission from the acceptor, D 615 is the fluorescent emission from the donor...
View article titled, CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2–DOP receptor heterodimer
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Articles

Functional complementation of high-efficiency resonance energy transfer: a new tool for the study of protein binding interactions in living cells

Paola Molinari, Ida Casella, Tommaso Costa
Journal: Biochemical Journal
Biochem J (2008) 409 (1): 251–261.
https://doi.org/10.1042/BJ20070803
Published: 11 December 2007
... between GPCRs (G-protein-coupled receptors) and β-arrestins. We show that complementation-induced BRET allows detection of the GPCR–β-arrestin interaction in a simple luminometric assay with high signal-to-noise ratio, good dynamic range and rapid response. Cell culture media, G418, hygromycin...
View article titled, Functional complementation of high-efficiency resonance energy transfer: a new tool for the study of protein binding interactions in living cells
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Articles

Functional characterization of human bitter taste receptors

Eduardo Sainz, Margaret M. Cavenagh, Joanne Gutierrez, James F. Battey, John K. Northup, Susan L. Sullivan
Journal: Biochemical Journal
Biochem J (2007) 403 (3): 537–543.
https://doi.org/10.1042/BJ20061744
Published: 12 April 2007
...Eduardo Sainz; Margaret M. Cavenagh; Joanne Gutierrez; James F. Battey; John K. Northup; Susan L. Sullivan The T2Rs belong to a multi-gene family of G-protein-coupled receptors responsible for the detection of ingested bitter-tasting compounds. The T2Rs are conserved among mammals with the human...
View article titled, Functional characterization of human bitter taste receptors
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Articles

In vivo DNase I-mediated footprinting analysis along the human bradykinin B1 receptor ( BDKRB1 ) gene promoter: evidence for cell-specific regulation

Martin ANGERS, Régen DROUIN, Magdalena BACHVAROVA, Isabelle PARADIS, Brad BISSELL, Makoto HIROMURA, Anny USHEVA, Dimcho BACHVAROV
Journal: Biochemical Journal
Biochem J (2005) 389 (1): 37–46.
https://doi.org/10.1042/BJ20042104
Published: 21 June 2005
... receptor: an inducible G protein coupled receptor Can. J. Physiol. Pharmacol. 1997 75 725 730 2 Marceau F. Hess J. F. Bachvarov D. R. The B1 receptors for bradykinins Pharmacol. Rev. 1998 50 357 386 3 Pesquero J. B. Araujo R. C. Heppenstall P. A. Stucky...
View article titled, In vivo DNase I-mediated footprinting analysis along the human bradykinin B1 receptor ( BDKRB1 ) gene promoter: evidence for cell-specific regulation
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Articles

Role of the ERC motif in the proximal part of the second intracellular loop and the C-terminal domain of the human prostaglandin F 2α receptor (hFP-R) in G-protein coupling control

Andrea PATHE-NEUSCHÄFER-RUBE, Frank NEUSCHÄFER-RUBE, Gerhard P. PÜSCHEL
Journal: Biochemical Journal
Biochem J (2005) 388 (1): 317–324.
https://doi.org/10.1042/BJ20041321
Published: 10 May 2005
... motif at the beginning of the second intracellular loop is highly conserved throughout the G-protein-coupled receptor family and appears to be crucial for controlling agonist-dependent receptor activation. It is replaced by an ERC motif in the FP-R and no evidence for the relevance of this motif...
View article titled, Role of the ERC motif in the proximal part of the second intracellular loop and the C-terminal domain of the human prostaglandin F 2α receptor (hFP-R) in G-protein coupling control
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Articles

The sustainability of interactions between the orexin-1 receptor and β-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation

Sandra MILASTA, Nicholas A. EVANS, Laura ORMISTON, Shelagh WILSON, Robert J. LEFKOWITZ, Graeme MILLIGAN
Journal: Biochemical Journal
Biochem J (2005) 387 (3): 573–584.
https://doi.org/10.1042/BJ20041745
Published: 26 April 2005
... of interaction with β-arrestin-2, and indicate an important role of β-arrestin scaffolding in defining the kinetics of orexin-1 receptor-mediated ERK MAPK activation. Efforts to identify a ligand able to activate a GPCR (G-protein-coupled receptor), initially denoted HFGAN72, led to the discovery...
View article titled, The sustainability of interactions between the orexin-1 receptor and β-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation
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Articles

Novel evolutionary lineages of the invertebrate oxytocin/vasopressin superfamily peptides and their receptors in the common octopus ( Octopus vulgaris )

Atsuhiro KANDA, Honoo SATAKE, Tsuyoshi KAWADA, Hiroyuki MINAKATA
Journal: Biochemical Journal
Biochem J (2005) 387 (1): 85–91.
https://doi.org/10.1042/BJ20041230
Published: 22 March 2005
... under the accession numbers AB112347, AB116233, AB158493, AB158494, AB158495, AB158496 and AB158497. 21 7 2004 18 10 2004 25 10 2004 25 10 2004 The Biochemical Society, London 2005 cephalotocin cloning octopressin G-protein-coupled receptor genome structure...
View article titled, Novel evolutionary lineages of the invertebrate oxytocin/vasopressin superfamily peptides and their receptors in the common octopus ( Octopus vulgaris )
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Includes: Supplementary data
Articles

Determination of the minimal functional ligand-binding domain of the GABA B(1b) receptor

Daniela DERIU, Martin GASSMANN, Susan FIRBANK, Dorothee RISTIG, Christina LAMPERT, Johannes MOSBACHER, Wolfgang FROESTL, Klemens KAUPMANN, Bernhard BETTLER, Markus G. GRÜTTER
Journal: Biochemical Journal
Biochem J (2005) 386 (3): 423–431.
https://doi.org/10.1042/BJ20040804
Published: 08 March 2005
... receptors (where GABA stands for γ-aminobutyric acid), which belong to the G-protein-coupled receptor gene family. Functional GABA B receptors are assembled from two subunits GABA B(1) (GABA B receptor subtype 1) and GABA B(2) . For the GABA B(1) subunit, which binds the neurotransmitter GABA, two variants...
View article titled, Determination of the minimal functional ligand-binding domain of the GABA B(1b) receptor
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Articles

Regulation of adenylate cyclase type VIII splice variants by acute and chronic G i/o -coupled receptor activation

Debora STEINER, Tomer AVIDOR-REISS, Ester SCHALLMACH, Elena BUTOVSKY, Nirit LEV, Zvi VOGEL
Journal: Biochemical Journal
Biochem J (2005) 386 (2): 341–348.
https://doi.org/10.1042/BJ20041670
Published: 22 February 2005
... cAMP dopamine receptor G-protein-coupled receptor opiate receptor superactivation [2- 3 H]Adenine (30.0 Ci/mmol) was purchased from Amersham Pharmacia Biotech (Piscataway, NJ, U.S.A.). Morphine and naloxone were obtained from the National Institute of Drug Abuse, Research Technology...
View article titled, Regulation of adenylate cyclase type VIII splice variants by acute and chronic G i/o -coupled receptor activation
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Articles

Involvement of a cytoplasmic-tail serine cluster in urotensin II receptor internalization

Christophe D. PROULX, May SIMAAN, Emanuel ESCHER, Stéphane A. LAPORTE, Gaétan GUILLEMETTE, Richard LEDUC
Journal: Biochemical Journal
Biochem J (2005) 385 (1): 115–123.
https://doi.org/10.1042/BJ20040807
Published: 14 December 2004
...Christophe D. PROULX; May SIMAAN; Emanuel ESCHER; Stéphane A. LAPORTE; Gaétan GUILLEMETTE; Richard LEDUC Most G-protein-coupled receptors that undergo agonist-dependent internalization require the presence of specific cytoplasmic-tail residues to initiate interactions with proteins of the endocytic...
View article titled, Involvement of a cytoplasmic-tail serine cluster in urotensin II receptor internalization
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Articles

Identification of a novel receptor for an invertebrate oxytocin/vasopressin superfamily peptide: molecular and functional evolution of the oxytocin/vasopressin superfamily

Tsuyoshi KAWADA, Atsuhiro KANDA, Hiroyuki MINAKATA, Osamu MATSUSHIMA, Honoo SATAKE
Journal: Biochemical Journal
Biochem J (2004) 382 (1): 231–237.
https://doi.org/10.1042/BJ20040555
Published: 10 August 2004
...′-CCGCTCTCCACAAATGGAG-3′) and a primer complementary to nt 1444–1462 (5′-CTTCAAAGGGAGCATGTGG-3′). The amplified products were subcloned and sequenced using several gene-specific primers. annetocin receptor earthworm oxytocin G-protein-coupled receptor vasopressin Oxytocin (OT) and vasopressin (VP...
View article titled, Identification of a novel receptor for an invertebrate oxytocin/vasopressin superfamily peptide: molecular and functional evolution of the oxytocin/vasopressin superfamily
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Articles

Agonist-dependent up-regulation of thyrotrophin-releasing hormone receptor protein

Laurie B. COOK, Patricia M. HINKLE
Journal: Biochemical Journal
Biochem J (2004) 380 (3): 815–821.
https://doi.org/10.1042/bj20031467
Published: 15 June 2004
... 2 3 2004 17 3 2004 17 3 2004 G-protein-coupled receptor protein kinase C thyrotrophin-releasing hormone (TRH) thyrotrophin-releasing hormone receptor (TRHR) Abbreviations used: GFP, green fluorescent protein; HA, haemagglutinin; HEK-293 cells, human embryonic kidney...
View article titled, Agonist-dependent up-regulation of thyrotrophin-releasing hormone receptor protein
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Articles

Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein

Andrea M. HAQQ, Patricia RENÉ, Toshiro KISHI, Kathy KHONG, Charlotte E. LEE, Hongyan LIU, Jeffrey M. FRIEDMAN, Joel K. ELMQUIST, Roger D. CONE
Journal: Biochemical Journal
Biochem J (2003) 376 (3): 595–605.
https://doi.org/10.1042/bj20031241
Published: 15 December 2003
... nucleus of hypothalamus and the dorsal motor nucleus of the vagus. Key words: attractin, glutathione S-transferase pull-down, G- protein-coupled receptor, melanocortin receptor, yeast two- hybrid. INTRODUCTION The pivotal role of the MC4-R (melanocortin 4 receptor) in the control of energy homoeostasis...
View article titled, Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein
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Articles

Requirement for direct cross-talk between B1 and B2 kinin receptors for the proliferation of androgen-insensitive prostate cancer PC3 cells

Liza BARKI-HARRINGTON, Angela L. BOOKOUT, Gaofeng WANG, Maria E. LAMB, L.M. Fredrik LEEB-LUNDBERG, Yehia DAAKA
Journal: Biochemical Journal
Biochem J (2003) 371 (2): 581–587.
https://doi.org/10.1042/bj20021708
Published: 15 April 2003
... The Biochemical Society, London ©2003 2003 bradykinin G-protein-coupled receptor mitogen-activated protein kinase (MAPK) receptor dimerization Abbreviations used: AT1R, angiotensin II type 1 receptor; BK, bradykinin; B1R, BK receptor 1; B2R, BK receptor 2; EGF, epidermal growth factor; ERK...
View article titled, Requirement for direct cross-talk between B1 and B2 kinin receptors for the proliferation of androgen-insensitive prostate cancer PC3 cells
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Articles

Photolabelling the rat urotensin II/GPR14 receptor identifies a ligand-binding site in the fourth transmembrane domain

Antony A. BOUCARD, Simon S. SAUVÉ, Gaétan GUILLEMETTE, Emanuel ESCHER, Richard LEDUC
Journal: Biochemical Journal
Biochem J (2003) 370 (3): 829–838.
https://doi.org/10.1042/bj20021566
Published: 15 March 2003
..., G-protein-coupled receptor; M184L (etc.), Met 184 →Leu mutant (etc.); PNGase-F, peptide N-glycosidase F; U-II, urotensin II. Biochem. J. (2003) 370, 829 838 (Printed in Great Britain) 829 Photolabelling the rat urotensin II/GPR14 receptor identifies a ligand-binding site in the fourth...
View article titled, Photolabelling the rat urotensin II/GPR14 receptor identifies a ligand-binding site in the fourth transmembrane domain
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Articles

Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases

Dezheng ZHAO, Sabina KUHNT-MOORE, Huiyan ZENG, Amy PAN, Jack S. WU, Simos SIMEONIDIS, Mary P. MOYER, Charalabos POTHOULAKIS
Journal: Biochemical Journal
Biochem J (2002) 368 (2): 665–672.
https://doi.org/10.1042/bj20020950
Published: 01 December 2002
... for the expression of genes involved in inflammation [22]. NF-jB consists of homodimers and heterodimers of the Rel family proteins, including p50, p52, p65, c-Rel, and Rel-B, of which the Abbreviations used: GPCR, G-protein-coupled receptor ; IL, interleukin ; LacZ, b-galactosidase ; MAPK, mitogen-activated protein...
View article titled, Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases
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Articles

Growth inhibition by the muscarinic M3 acetylcholine receptor: evidence for p21Cip1/Waf1 involvement in G1 arrest

Drew BURDON, Rajnikant PATEL, R.A. John CHALLISS, Jonathan L. BLANK
Journal: Biochemical Journal
Biochem J (2002) 367 (2): 549–559.
https://doi.org/10.1042/bj20020446
Published: 15 October 2002
...) extracellular signal-regulated protein kinase (ERK) G-protein-coupled receptor growth regulation Abbreviations used: AChR, acetylcholine receptor; AP-1, activator-protein 1; CCh, carbachol; CDK, cyclin-dependent kinase; CDKI, cyclin-dependent kinase inhibitor; CHO, Chinese-hamster ovary; Cip1, CDK...
View article titled, Growth inhibition by the muscarinic M3 acetylcholine receptor: evidence for p21Cip1/Waf1 involvement in G1 arrest
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Articles

Cloning, structural characterization and functional expression of a zebrafish bradykinin B2-related receptor

Torun DUNÉR, J. Michael CONLON, Jyrki P. KUKKONEN, Karl E.O. ÅKERMAN, Yi-Lin YAN, John H. POSTLETHWAIT, Dan LARHAMMAR
Journal: Biochemical Journal
Biochem J (2002) 364 (3): 817–824.
https://doi.org/10.1042/bj20011201
Published: 15 June 2002
...-mail [email protected] ). 15 8 2001 28 2 2002 8 4 2002 The Biochemical Society, London ©2002 2002 Ca 2+ chromosome G-protein-coupled receptor evolution teleost trout Abbreviations used: BK, bradykinin; B1, BK receptor B1; B2, BK receptor B2; bdkrb2 , zebrafish BK...
View article titled, Cloning, structural characterization and functional expression of a zebrafish bradykinin B2-related receptor
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Articles

De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis

Teresa GÓMEZ del PULGAR, Guillermo VELASCO, Cristina SÁNCHEZ, Amador HARO, Manuel GUZMÁN
Journal: Biochemical Journal
Biochem J (2002) 363 (1): 183–188.
https://doi.org/10.1042/bj3630183
Published: 22 March 2002
... by binding to specific plasma membrane G-protein-coupled receptors [1,2]. To date, two different cannabinoid receptors have been cloned and characterized from mammalian tissues, CB " [3] and CB # [4]. Activation of these receptors has been shown to trigger several G i/o -protein-mediated signalling pathways...
View article titled, De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis
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Articles

Chimaeric gonadotropin-releasing hormone (GnRH) peptides with improved affinity for the catfish (Clarias gariepinus) GnRH receptor

Marion BLOMENRÖHR, Ton TER LAAK, Ronald KÜHNE, Michael BEYERMANN, Eveline HUND, Jan BOGERD, Rob LEURS
Journal: Biochemical Journal
Biochem J (2002) 361 (3): 515–523.
https://doi.org/10.1042/bj3610515
Published: 25 January 2002
...-mail [email protected] ). 14 5 2001 4 10 2001 7 11 2001 The Biochemical Society, London ©2002 2002 computational modelling G-protein-coupled receptor ligand selectivity site-directed mutagenesis Abbreviations used: GnRH, gonadotropin-releasing hormone; cfGnRH, catfish...
View article titled, Chimaeric gonadotropin-releasing hormone (GnRH) peptides with improved affinity for the catfish (Clarias gariepinus) GnRH receptor
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Articles

Agonist-promoted trafficking of human bradykinin receptors: arrestin- and dynamin-independent sequestration of the B2 receptor and bradykinin in HEK293 cells

Maria E. LAMB, Willem F. C. DE WEERD, L. M. Fredrik LEEB-LUNDBERG
Journal: Biochemical Journal
Biochem J (2001) 355 (3): 741–750.
https://doi.org/10.1042/bj3550741
Published: 24 April 2001
[email protected] ). 18 8 2000 25 1 2001 16 2 2001 The Biochemical Society, London © 2001 2001 caveolae clathrin-coated pit G-protein-coupled receptor internalization peptide Biochem. J. (2001) 355, 741 750 (Printed in Great Britain) 741 Agonist-promoted trafficking of human...
View article titled, Agonist-promoted trafficking of human bradykinin receptors: arrestin- and dynamin-independent sequestration of the B2 receptor and bradykinin in HEK293 cells
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Articles

Monocyte chemoattractant protein 1 causes differential signalling mediated by proline-rich tyrosine kinase 2 in THP-1 cells

Masahide YAMASAKI, Hidenori ARAI, Noboru ASHIDA, Kenji ISHII, Toru KITA
Journal: Biochemical Journal
Biochem J (2001) 355 (3): 751–756.
https://doi.org/10.1042/bj3550751
Published: 24 April 2001
.... However, Pyk2 is not always involved in MCP-1-mediated signalling pathways. Key words: chemokine receptor 2, ERK, G-protein-coupled receptor, p38. Protein tyrosine kinases (PTKs) transduce key extracellular signals that trigger various biological events such as cytoskeletal rearrangement and mitogenesis...
View article titled, Monocyte chemoattractant protein 1 causes differential signalling mediated by proline-rich tyrosine kinase 2 in THP-1 cells
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Articles

Genomic organization and characterization of splice variants of the human histamine H3 receptor

Francis COGÉ, Sophie-Pénélope GUÉNIN, Valérie AUDINOT, Anne RENOUARD-TRY, Philippe BEAUVERGER, Christelle MACIA, Christine OUVRY, Nadine NAGEL, Hervé RIQUE, Jean A. BOUTIN, Jean-Pierre GALIZZI
Journal: Biochemical Journal
Biochem J (2001) 355 (2): 279–288.
https://doi.org/10.1042/bj3550279
Published: 06 April 2001
... be addressed (e-mail [email protected] ). 13 9 2000 2 1 2001 6 2 2001 The Biochemical Society, London © 2001 2001 alternative splicing histamine H3-receptor gene G-protein-coupled receptor third intracellular loop Biochem. J. (2001) 355, 279 288 (Printed in Great...
View article titled, Genomic organization and characterization of splice variants of the human histamine H3 receptor
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Articles

A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in inhibition of desensitization and endocytosis, and a dose-dependent shift in p42/44 mitogen-activated protein kinase activation and chemotaxis

Jeannie M. GRIPENTROG, Algirdas J. JESAITIS, Heini M. MIETTINEN
Journal: Biochemical Journal
Biochem J (2000) 352 (2): 399–407.
https://doi.org/10.1042/bj3520399
Published: 24 November 2000
...Jeannie M. GRIPENTROG; Algirdas J. JESAITIS; Heini M. MIETTINEN The formyl peptide receptor (FPR) is a G-protein-coupled receptor (GPCR) that mediates chemotaxis and stimulates the mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinase pathway. We have examined the functional...
View article titled, A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in inhibition of desensitization and endocytosis, and a dose-dependent shift in p42/44 mitogen-activated protein kinase activation and chemotaxis
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Articles

The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt

Teresa GÓMEZ DEL PULGAR, Guillermo VELASCO, Manuel GUZMÁN
Journal: Biochemical Journal
Biochem J (2000) 347 (2): 369–373.
https://doi.org/10.1042/bj3470369
Published: 10 April 2000
...Teresa GÓMEZ DEL PULGAR; Guillermo VELASCO; Manuel GUZMÁN Cannabinoids exert most of their effects in the central nervous system through the CB 1 cannabinoid receptor. This G-protein-coupled receptor has been shown to be functionally coupled to inhibition of adenylate cyclase, modulation of ion...
View article titled, The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt
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Articles

Identification of protein kinase C phosphorylation sites in the angiotensin II (AT1A) receptor

Hongwei QIAN, Luisa PIPOLO, Walter G. THOMAS
Journal: Biochemical Journal
Biochem J (1999) 343 (3): 637–644.
https://doi.org/10.1042/bj3430637
Published: 25 October 1999
... mediator of the biological actions of AngII. AT " receptors are members of the seven-transmembrane-spanning G-protein- coupled receptor (GPCR) superfamily and activate G-proteins through membrane-proximal regions of the third cytoplasmic loop [3,4] and C-terminus in the receptor [5,6]. AT " activation...
View article titled, Identification of protein kinase C phosphorylation sites in the angiotensin II (AT1A) receptor
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Articles

Large-scale production and purification of functional recombinant bovine rhodopsin with the use of the baculovirus expression system

Corné H. W. KLAASSEN, Petra H. M. BOVEE-GEURTS, Godelieve L. J. DECALUWÉ, Willem J. DEGRIP
Journal: Biochemical Journal
Biochem J (1999) 342 (2): 293–300.
https://doi.org/10.1042/bj3420293
Published: 24 August 1999
... transmembrane- spanning domains and belongs to the large family of G-protein- coupled receptors [1]. Members of this family of receptors are widespread in many regulatory functions throughout the ver- tebrate body. Rhodopsin is probably the only member of this family that can be purified in reasonable...
View article titled, Large-scale production and purification of functional recombinant bovine rhodopsin with the use of the baculovirus expression system
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Articles

cDNA cloning and characterization of guinea-pig leukotriene B 4 receptor

Kazuyuki MASUDA, Takehiko YOKOMIZO, Takashi IZUMI, Takao SHIMIZU
Journal: Biochemical Journal
Biochem J (1999) 342 (1): 79–85.
https://doi.org/10.1042/bj3420079
Published: 10 August 1999
... % are important in host defence mechanisms against foreign organisms. The biological properties of LTB % are comparable to those of other chemotactic factors, such as C5a and bacterial formyl peptide ( fMLP and are considered to be mediated through a G-protein-coupled receptor expressed on the cell surface...
View article titled, cDNA cloning and characterization of guinea-pig leukotriene B 4 receptor
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Articles

Conserved polar residues in the transmembrane domain of the human tachykinin NK2 receptor: functional roles and structural implications

Dan DONNELLY, Stuart MAUDSLEY, J. Paul GENT, Rachel N. MOSER, Craig R. HURRELL, John B. C. FINDLAY
Journal: Biochemical Journal
Biochem J (1999) 339 (1): 55–61.
https://doi.org/10.1042/bj3390055
Published: 25 March 1999
... [in transmembrane helix 1 (TM1)], Asp-79 (TM2) and Asn-303 (TM7), which are highly conserved in the transmembrane domain in the rhodopsin family of G-protein-coupled receptors. Wild-type and mutant receptors were expressed in both COS-1 cells and Xenopus oocytes. The results show that the N51D mutation results...
View article titled, Conserved polar residues in the transmembrane domain of the human tachykinin NK2 receptor: functional roles and structural implications
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Articles

Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptors

Paul G. WYLIE, R. A. John CHALLISS, Jonathan L. BLANK
Journal: Biochemical Journal
Biochem J (1999) 338 (3): 619–628.
https://doi.org/10.1042/bj3380619
Published: 08 March 1999
... and G- protein-coupled receptors (GPCRs) that promote mitogenesis, differentiation or hypertrophy. ERKs mediate these effects by phosphorylating various substrates, including cytoplasmic en- zymes (e.g. phospholipase A # , p90 ribosomal protein S6 kinase) and nuclear transcription factors (e.g. ELK-1...
View article titled, Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptors
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Articles

The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways

Koichi GONDA, Hiroyuki OKAMOTO, Noriko TAKUWA, Yutaka YATOMI, Hiroshi OKAZAKI, Takeshi SAKURAI, Sadao KIMURA, Rannar SILLARD, Kiyonori HARII, Yoh TAKUWA
Journal: Biochemical Journal
Biochem J (1999) 337 (1): 67–75.
https://doi.org/10.1042/bj3370067
Published: 17 December 1998
... and -insensitive G-proteins to multiple effector pathways. 29 6 1998 21 9 1998 26 10 1998 The Biochemical Society, London © 1999 1999 adenylate cyclase G-protein-coupled receptor lysophospholipid mitogen-activated protein kinase phospholipase C Biochem. J. (1999) 337, 67 75...
View article titled, The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways
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