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Keywords: G-protein-coupled receptor (GPCR)
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Articles
Biochem J (2016) 473 (22): 4173–4192.
Published: 10 November 2016
...Diana Zindel; Sandra Engel; Andrew R. Bottrill; Jean-Philippe Pin; Laurent Prézeau; Andrew B. Tobin; Moritz Bünemann; Cornelius Krasel; Adrian J. Butcher The parathyroid hormone receptor 1 (PTH1R) is a member of family B of G-protein-coupled receptors (GPCRs), predominantly expressed in bone...
Articles
Biochem J (2016) 473 (14): 2179–2186.
Published: 12 July 2016
... To whom correspondence should be addressed (email bohuangp@ust.hk ). 12 1 2016 12 5 2016 16 5 2016 17 5 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 A 2B adenosine receptor actinin G-protein-coupled receptor...
Includes: Supplementary data
Articles
Biochem J (2014) 458 (1): 131–140.
Published: 20 January 2014
..., inducing faster termination of signalling by faster dissociation of Gα q and p63RhoGEF. Förster resonance energy transfer (FRET) Gα q G-protein-coupled receptor (GPCR) histaminergic receptor p63RhoGEF regulator of G-protein signalling 2 (RGS2) GTPases of the Rho family (RhoGTPases...
Includes: Supplementary data
Articles
Biochem J (2014) 457 (2): 313–322.
Published: 20 December 2013
... binding element in helix 8 of CCR2 for the cytosolic regulator FROUNT that mediates chemotactic signalling. chemokine (C-C motif) receptor 2 (CCR2) chemo-taxis FROUNT G-protein-coupled receptor (GPCR) helix 8 The chemokine receptor family comprises 19 GPCRs (G-protein-coupled receptors...
Includes: Supplementary data
Articles
Biochem J (2013) 453 (3): 345–356.
Published: 12 July 2013
... 100020, China. 3 To whom correspondence should be addressed (email jq_he@ccmu.edu.cn ). 19 12 2012 24 5 2013 24 5 2013 24 5 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 angiotensin-(1–7) G-protein-coupled receptor (GPCR) Mas PDZ...
Articles
Biochem J (2013) 452 (2): 303–312.
Published: 10 May 2013
... 25 3 2013 25 3 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 Förster resonance energy transfer (FRET) spectrometry G-protein-coupled receptor (GPCR) muscarinic receptor spectrally resolved FRET 1 These authors contributed equally...
Includes: Supplementary data
Articles
Biochem J (2013) 450 (3): 443–457.
Published: 28 February 2013
... of those systems. conformational dynamics G-protein-coupled receptor (GPCR) ligand binding and structural activation solid-state NMR structure determination GPCRs (G-protein-coupled receptors) are versatile signalling molecules at the cell surface and make up the largest and most diverse...
Articles
Biochem J (2012) 441 (1): 379–386.
Published: 14 December 2011
... should be addressed (email lliuche@temple.edu ). 22 6 2011 11 8 2011 25 8 2011 25 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 A118G glycosylation G-protein-coupled receptor (GPCR) μ opioid receptor (MOPR) N-glycan protein stability...
Articles
Biochem J (2011) 438 (2): 359–367.
Published: 12 August 2011
...-coupled receptor (GPCR) palmitoylation proteinase-activated receptor 2 (PAR 2 ) Post-translational modifications of GPCRs (G-protein-coupled receptors) can extensively regulate numerous aspects of their biology, including cell-surface expression, trafficking, folding, signalling and ligand...
Articles
Biochem J (2011) 438 (1): 191–202.
Published: 27 July 2011
... 3 5 2011 11 5 2011 11 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 β-adrenoceptor β-arrestin-2 G-protein-coupled receptor (GPCR) ligand efficacy protein–protein interaction resonance energy transfer Although β 1 - and β 2 -AR...
Includes: Supplementary data
Articles
Biochem J (2011) 435 (2): 365–371.
Published: 29 March 2011
... 2 2 2011 2 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 G-protein-coupled receptor (GPCR) metabotropic glutamate receptor (mGluR) protein inhibitor of activated STAT (signal transducer and activator of transcription) 1 (Pias1) retina...
Articles
Biochem J (2011) 434 (1): 11–24.
Published: 27 January 2011
... [ 68 – 69 ] and Th2 lymphocytes [ 66 ], targeting CCR3 may provide ‘added value’. 1 email j.pease@imperial.ac.uk allergy asthma chemokine G-protein-coupled receptor (GPCR) inflammation leucocyte Allergic diseases such as asthma, allergic rhinitis and atopic dermatitis...
Articles
Biochem J (2011) 433 (3): 435–440.
Published: 14 January 2011
... proteins from their receptors through covalent modification. The results of the present study provide the long-awaited biochemical proof of the GPCR nature of Fz receptors. Frizzled (Fz) G-protein-coupled receptor (GPCR) guanine-nucleotide-exchange factor (GEF) Wnt3a 1 To whom...
Articles
Biochem J (2011) 433 (1): 11–18.
Published: 15 December 2010
... Biochemical Society 2011 adrenergic receptor β-arrestin G-protein-coupled receptor (GPCR) heteromerization mitogen-activated protein kinase (MAPK) signal specificity GPCRs (G-protein-coupled receptors), also called seven-transmembrane receptors or heptahelical receptors, are a large family...
Articles
Biochem J (2010) 432 (3): 451–459.
Published: 25 November 2010
... should be addressed (email graeme.milligan@glasgow.ac.uk ). 16 8 2010 1 10 2010 5 10 2010 5 10 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 agonist β-arrestin-2 drug discovery G-protein-coupled receptor (GPCR) GPR35 screening GPR35...
Articles
Biochem J (2010) 428 (2): 235–245.
Published: 13 May 2010
... ). 25 1 2010 15 3 2010 26 3 2010 26 3 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 arrestin β 2 -adrenergic receptor G-protein-coupled receptor (GPCR) G-protein-coupled receptor kinase (GRK) phosphatase thyrotropin-releasing hormone receptor...
Articles
Biochem J (2010) 428 (1): 1–10.
Published: 28 April 2010
... from those of native vertebrate proteins. G-protein-coupled receptor (GPCR) heterotrimeric G-protein photoactivated rhodopsin transducin (G t ) The discovery of molecular events involved in visual transduction, especially in rod photoreceptor cells, has led to an increased understanding...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2009) 424 (1): 39–45.
Published: 23 October 2009
... receptor [ 25 , 27 ]. β-Lactamase reporter assay G-protein-coupled receptor (GPCR) imidazoline receptor pharmacology trace amine trace amine-associated receptor 1 Trace amines, including tyramine, tryptamine, octopamine and PEA (β-phenylethylamine), have been found in many organisms from...
Articles
Biochem J (2009) 423 (1): 129–143.
Published: 14 September 2009
...) diabetic nephropathy fibronectin G-protein-coupled receptor (GPCR) phosphoinositide 3-kinase (PI3K) type IV collagen The kidney is a major target organ of diabetic complications. Mesangial expansion with matrix accumulation is the pathological hallmark of diabetic nephropathy [ 1...
Articles
Biochem J (2009) 418 (1): 163–172.
Published: 28 January 2009
... of the receptor. 1 To whom correspondence should be addressed (email jean-luc.parent@usherbrooke.ca ). 30 4 2008 16 10 2008 4 11 2008 4 11 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 β 2 -adrenergic receptor (β2AR) G-protein-coupled receptor...
Articles
Biochem J (2009) 417 (1): 161–172.
Published: 12 December 2008
... permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. endoplasmic reticulum retention G-protein-coupled receptor (GPCR) glycosylation pharmacological chaperone It is now widely accepted that many GPCRs (G...
Articles
Biochem J (2008) 414 (1): 121–131.
Published: 29 July 2008
... histamine H 4 receptor G-protein-coupled receptor (GPCR) isoform oligomerization The hH 4 R [human H 4 R (histamine H 4 receptor)] is the fourth and most recently discovered member of the GPCR (G-protein-coupled receptor) subfamily of histamine receptors [ 1 – 6 ]. The H 4 R is predominantly...
Includes: Supplementary data
Articles
Biochem J (2008) 412 (1): 103–112.
Published: 25 April 2008
... determined by anion-exchange chromatography as described previously [ 27 ]. allosteric protein G-protein-coupled receptor (GPCR) inverse agonist M 3 muscarinic acetylcholine receptor (M 3 R) mutagenesis signal transduction GPCRs (G-protein-coupled receptors) recognize an extraordinary...
Includes: Supplementary data
Articles
Biochem J (2007) 402 (1): 51–61.
Published: 25 January 2007
... ). 22 6 2006 23 10 2006 25 10 2006 25 10 2006 The Biochemical Society, London 2007 G-protein-coupled receptor (GPCR) ligand binding photolabelling urantide urotensin II U-II (urotensin II, Glu-Thr-Pro-Asp- Cys-Phe-Trp-Lys-Tyr-Cys -Val) is a cyclic undecapeptide...
Includes: Supplementary data
Articles
Biochem J (2007) 401 (2): 485–495.
Published: 21 December 2006
... should be addressed (email vladimir.katanaev@uni-konstanz.de ). 6 4 2006 1 9 2006 21 9 2006 21 9 2006 The Biochemical Society, London 2007 G-protein-coupled receptor (GPCR) kinetics modelling oscillation transient response trimeric G-protein GPCRs (G...
Includes: Supplementary data
Articles
Biochem J (2006) 399 (3): 493–501.
Published: 13 October 2006
... extracellular-signal-regulated kinase (ERK) pathway G-protein-coupled receptor (GPCR) protein kinase C (PKC) Raf Ras In cardiac myocytes, as in other cell types, numerous cellular processes are sensitive to changes in pH i (intracellular pH). In particular, almost every step in the excitation...
Articles
Biochem J (2006) 395 (1): 125–135.
Published: 15 March 2006
... 12 2005 21 12 2005 The Biochemical Society, London 2006 gonadotropin-releasing hormone (GnRH) invertebrate G-protein-coupled receptor (GPCR) molecular evolution reproduction GnRH (gonadotropin-releasing hormone) is responsible for various physiological actions, including...
Articles
Biochem J (2006) 393 (1): 161–169.
Published: 12 December 2005
...-protein-coupled receptor (GPCR) mutagenesis neuropeptide Y (NPY) receptor Y1 three-dimensional model Secondly, the five mammalian receptor subtypes for the NPY-family peptides display unusually divergent primary structures. With only 27–32% overall identity, the three subtypes Y1, Y2 and Y5...
Includes: Supplementary data
Articles
Biochem J (2005) 390 (2): 455–464.
Published: 23 August 2005
... be addressed (email schuelein@fmp-berlin.de ). 17 1 2005 5 5 2005 18 5 2005 18 5 2005 The Biochemical Society, London 2005 corticotropin-releasing factor receptor 1 (CRF-R1) endoplasmic reticulum functional receptor G-protein-coupled receptor (GPCR) signal peptide...
Articles
Biochem J (2005) 390 (1): 367–376.
Published: 09 August 2005
... 2005 4 5 2005 The Biochemical Society, London 2005 angiotensin II receptor subtype 1 (AT 1 receptor) degradation G-protein-coupled receptor (GPCR) N-glycosylation protein folding quality control A large number of hormones, neurotransmitters, chemokines and sensory stimuli...
Articles
Biochem J (2005) 389 (1): 187–195.
Published: 21 June 2005
... 2005 25 2 2005 The Biochemical Society, London 2005 computational model endothelial differentiation gene 6 (EDG6) G-protein-coupled receptor (GPCR) mutagenesis sphingosine 1-phosphate (S1P) sphingosine 1-phosphate receptor 4 (S1P 4 receptor) S1P (sphingosine 1-phosphate...
Includes: Supplementary data
Articles
Biochem J (2005) 385 (3): 625–637.
Published: 24 January 2005
... 9 2004 26 10 2004 26 10 2004 The Biochemical Society, London 2005 arrestin bioluminescence resonance energy transfer (BRET) fluorescence resonance energy transfer (FRET) G-protein-coupled receptor (GPCR) oligomerization A great deal of information is accumulating...
Articles
Biochem J (2004) 382 (1): 101–110.
Published: 10 August 2004
... Society, London 2004 G-protein-coupled receptor (GPCR) metabotropic glutamate receptor phosphorylation protein kinase C (PKC) P2X receptor P2Y receptor Extracellular ATP functions as a signalling molecule through the activation of P2X receptors [ 1 ]. Sources of ATP include co-release...
Articles
Biochem J (2004) 381 (1): 43–49.
Published: 22 June 2004
... To whom correspondence should be addressed (e-mail tba@le.ac.uk ). 7 4 2004 7 11 2003 1 4 2004 7 4 2004 The Biochemical Society, London 2004 apoptosis Bcl-2 caspase G-protein-coupled receptor (GPCR) M 3 -muscarinic receptor transcription GPCRs (G-protein...
Articles
Biochem J (2004) 380 (2): 475–486.
Published: 01 June 2004
... Nucleotide Sequence Databases under the accession numbers AY534915 and AY534916 respectively. 15 12 2003 9 2 2004 13 2 2004 13 2 2004 The Biochemical Society, London ©2004 2004 adrenocorticotropic hormone (ACTH) G-protein-coupled receptor (GPCR) hormone receptor...
Articles
Biochem J (2003) 376 (1): e7–e8.
Published: 15 November 2003
... mechanisms. 1 To whom correspondence should be addressed (e-mail ks14@mole.bio.cam.ac.uk ). 3 11 2003 3 11 2003 8 12 2003 The Biochemical Society, London ©2003 2003 agouti appetite attractin G-protein-coupled receptor (GPCR) melanocortin obesity Biochem. J. (2003...
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Biochem J (2003) 375 (3): 503–515.
Published: 01 November 2003
... adapter protein β-arrestin desensitization endocytosis G-protein-coupled receptor (GPCR) seven-membrane-spanning receptor (7MSR) Abbreviations used: AP, adapter protein; β 2 AR, β 2 -adrenergic receptor; βARK, β-adrenergic receptor kinase; ARF, ADP-ribosylation factor; ARNO, ARF nucleotide...
Articles
Biochem J (2003) 374 (2): 281–296.
Published: 01 September 2003
... investigation. 1 To whom correspondence should be addressed (e-mail gbw2@leicester.ac.uk ). 26 2 2003 3 6 2003 5 6 2003 5 6 2003 The Biochemical Society, London ©2003 2003 cross-talk G-protein-coupled receptor (GPCR) intracellular Ca 2+ release Ins(1,4,5) P 3...
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Biochem J (2003) 371 (2): 443–449.
Published: 15 April 2003
... anniversary of his birth. 2 To whom correspondence should be addressed (e-mail gpuesche@rz.uni-potsdam.de ). 11 9 2002 4 12 2002 8 1 2003 8 1 2003 The Biochemical Society, London ©2003 2003 G-protein-coupled receptor (GPCR) mutant structure–function relationship...