...Subhashree Murali; Gopala Krishna Aradhyam G protein-coupled receptors (GPCRs) serve as critical communication hubs, translating a wide range of extracellular signals into intracellular responses that govern numerous physiological processes. In class-A GPCRs, conserved motifs mediate conformational...

...Ryosuke Tany; Yuhei Goto; Yohei Kondo; Kazuhiro Aoki G-protein-coupled receptors (GPCRs) play an important role in sensing various extracellular stimuli, such as neurotransmitters, hormones, and tastants, and transducing the input information into the cell. While the human genome encodes more than...

... 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 G-protein-coupled receptors glucagon-like peptide-1 intracellular signalling Following nutrient ingestion, a number of incretin hormones are released from the gastrointestinal...

... of the Biochemical Society 2017 breast cancers G-protein-coupled receptors macropinocytosis phosphoinositide 3-kinase Rac Macropinosomes were analyzed by a modification of the method of Commisso et al. [ 19 ]. Briefly, images were analyzed in ImageJ. For a given experiment, a phase contrast...

...), a single TMD protein required by several seven-TMD G-protein-coupled receptors including the calcitonin receptor-like receptor (CLR). Ostβ/RAMP1 chimeras were expressed with Ostα and CLR. As expected, replacing the Ostβ TMD abolished transport activity; however, replacing either the entire N-terminal...

... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . G-protein-coupled receptors quaternary structure spatial intensity distribution analysis The concept that single-polypeptide G-protein-coupled receptors...

...Ashish K. Mishra; Megan Gragg; Michael R. Stoneman; Gabriel Biener; Julie A. Oliver; Przemyslaw Miszta; Slawomir Filipek; Valerică Raicu; Paul S.-H. Park Rhodopsin is a prototypical G-protein-coupled receptor (GPCR) that initiates phototransduction in the retina. The receptor consists...

... cytokines, and chemokines that bind to G-protein-coupled receptors (GPCRs). Regulators of G-protein signalling (RGSs) are a protein family that can act as GTPase-activating proteins for G αi - and G αq -class proteins. We have identified a new member of the R4 subfamily of RGS proteins, RGS18. RGS18...

... correspondence should be addressed (e-mail [email protected] ). 25 8 2000 16 10 2000 7 11 2000 The Biochemical Society, London © 2001 2001 acylation antibodies G-protein-coupled receptors recombinant baculovirus signal transduction Biochem. J. (2001) 353, 627 634 (Printed...