... to the plasma membrane, as did a catalytically inactive mutant of RhoGAP6. Overall, we have identified a novel interaction between RhoGAP6 and δ-COP which is mediated by conserved C-terminal di-tryptophan motifs, and which might control protein transport in platelets. ARHGAP6 G-proteins intracellular...

... 4.0 (CC BY) . Open access for this article was enabled by the participation of University of Liverpool in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. drug resistance G-proteins signaling...

... by the participation of the Univesity of Dundee in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. G-proteins leucine-rich repeat kinase Parkinson's disease signaling One-to four percent of all cases...

... these malignancies and other malignancies in which HRAS is mutated. For example, Fagin and colleagues recently showed that tipifarnib inhibits HRAS-driven dedifferentiated thyroid cancers in mouse models. They also noted instances of emergent resistance, through loss of NF1 or activation of the G-protein subunit...

... on behalf of the Biochemical Society 2017 ApoER2 cytoskeleton G-proteins membrane dynamics Reelin VLDLR Reelin is an extracellular glycoprotein, which is secreted by Cajal–Retzius cells during embryonic brain development and by GABAergic interneurons in the adult brain [ 1 – 4 ]. The full...

... a penetrant variant for inherited PD. CHIP G-proteins Parkinson's disease proteasome protein stability † Present address: Medical College of Wisconsin, Medical School, 8701 W Watertown Plank Rd, Milwaukee, WI 53226, U.S.A. ‡ Present address: Center for Cancer Research, Laboratory...

... of heterotrimeric G-proteins involving Gα i/o , rather than Gβγ, subunits. Because the lifetime and availability of Gα-GTP are regulated by regulators of G-protein signalling (RGS) and Gα i/o -Loco (GoLoco) domain-containing proteins via their GTPase-activating protein (GAP) and guanine-nucleotide-dissociation...

...Christina PANARETOU; Sharon A. TOOZE Heterotrimeric G-proteins, as well as small GTPases of the Rho and ADP-ribosylation factor (ARF) family, are implicated in the regulation of lipid kinases, including PtdIns 4-kinases and PtdIns(4) P 5-kinases. Here, we describe a PtdIns 4-kinase activity...

... and acquire the capability to synthesize haemoglobin. We used this cell system to study alterations in the levels of several G-protein subunits during the cell differentiation programme and to assess the involvement of G i α2 in this process. Western immunoblot analysis revealed the presence of G s α1, G s α2...

...Cynthia M. FERRARA; Samuel W. CUSHMAN Agents that activate the G-protein G i (e.g. adenosine) increase, and agents that activate G s [e.g. isoprenaline (isoproterenol)] decrease, steady-state insulin-stimulated glucose transport activity and cell-surface GLUT4 in isolated rat adipose cells without...

... of autofluorescent TRHR-1-GFP with that of the phosphoinositidase C-linked G-proteins G q α/G 11 α, identified by indirect immunofluorescence, was monitored concurrently. Addition of thyrotropin-releasing hormone resulted in rapid separation of TRHR-1-GFP and G q α/G 11 α signals as the receptor was internalized...

... inhibitors of AC activity. Inhibition of AC activity by collagen proceeds via two parallel pathways; the same is true for thrombin at moderate concentrations, and the two ligands act independently. The G-protein-dependence of these pathways is distinct from that mediating inhibition of AC activity...

.... 2 Present address: Eisai Research Institute, 4 Corporation Drive, Andover, MA 01810-2441, U.S.A. 3 To whom correspondence should be addressed (e-mail [email protected] ). 1 5 1998 6 11 1998 8 12 1998 The Biochemical Society, London © 1999 1999 G-proteins...