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1-4 of 4
Keywords: GLI1
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Articles
SUFU promotes GLI activity in a Hedgehog-independent manner in pancreatic cancer
Available to PurchaseBrooke D. Paradise, Vladimir G. Gainullin, Luciana L. Almada, Ashley N. Sigafoos, Sandhya Sen, Renzo E. Vera, Glancis Luzeena Raja Arul, Murat Toruner, David R. Pease, Alina L. Gonzalez, Fatima M. Mentucci, Daniel H. Grasso, Martin E. Fernandez-Zapico
Journal:
Biochemical Journal
Biochem J (2023) 480 (15): 1199–1216.
Published: 02 August 2023
..., and overexpression of BCL2 partially rescues the effect of reduced cell viability by SUFU KD. Further analysis using as a model GLI1, a major TF activator of the GLI family in PDAC cells, shows the interaction of SUFU and GLI1 in the nucleus through previously characterized domains. Chromatin immunoprecipitation...
Articles
GLI1 interaction with p300 modulates SDF1 expression in cancer-associated fibroblasts to promote pancreatic cancer cells migration
Available to PurchaseRenzo E. Vera, María J. Lamberti, Luciana L. Almada, Ezequiel J. Tolosa, Anne M. Vrabel, Ashley N. Sigafoos, Merih D. Toruner, Luis F. Flores, Viviana A. Rivarola, Natalia B. Rumie Vittar, Martín E. Fernández-Zapico
Journal:
Biochemical Journal
Biochem J (2023) 480 (3): 225–241.
Published: 14 February 2023
... transcriptional axis regulating the expression of SDF1, a major driver of cancer cell migration, involving the transcription factor GLI1 and histone acetyltransferase p300. We demonstrate that conditioned media from CAFs overexpressing GLI1 induce the migration of pancreatic cancer cells, and this effect...
Includes: Supplementary data
Articles
GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression
Available to PurchaseEzequiel J. Tolosa, Maite G. Fernandez-Barrena, Eriko Iguchi, Angela L. McCleary-Wheeler, Ryan M. Carr, Luciana L. Almada, Luis F. Flores, Renzo E. Vera, Germine W. Alfonse, David L. Marks, Tara L. Hogenson, Anne M. Vrabel, Isaac P. Horn, Amanda N. Koenig, Stephanie L. Safgren, Ashley N. Sigafoos, Mert Erkan, Paola A. Romecin-Duran, Alejandro Sarabia Gonzalez, Bo Zhou, Delphine Javelaud, Veronique Marsaud, Rondell P. Graham, Alain Mauviel, Sherine F. Elsawa, Martin E. Fernandez-Zapico
Journal:
Biochemical Journal
Biochem J (2020) 477 (17): 3131–3145.
Published: 04 September 2020
...; Mert Erkan; Paola A. Romecin-Duran; Alejandro Sarabia Gonzalez; Bo Zhou; Delphine Javelaud; Veronique Marsaud; Rondell P. Graham; Alain Mauviel; Sherine F. Elsawa; Martin E. Fernandez-Zapico The Hedgehog-regulated transcription factors GLI1 and GLI2 play overlapping roles in development and disease...
Includes: Supplementary data
Articles
Inhibition of GLI1 gene activation by Patched1
Available to PurchaseFahimeh Rahnama, Takashi Shimokawa, Matthias Lauth, Csaba Finta, Priit Kogerman, Stephan Teglund, Rune Toftgård, Peter G. Zaphiropoulos
Journal:
Biochemical Journal
Biochem J (2006) 394 (1): 19–26.
Published: 27 January 2006
... through SMO (Smoothened) and represses the expression of HH target genes such as the transcription factor GLI1 ( gli oma 1 ) as well as PTCH1 . Up-regulation of these genes has been observed in several cancer forms, including basal cell carcinoma, digestive track tumours and small cell lung cancer...
