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Keywords: GLI1
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Biochem J (2023) 480 (15): 1199–1216.
Published: 02 August 2023
..., and overexpression of BCL2 partially rescues the effect of reduced cell viability by SUFU KD. Further analysis using as a model GLI1, a major TF activator of the GLI family in PDAC cells, shows the interaction of SUFU and GLI1 in the nucleus through previously characterized domains. Chromatin immunoprecipitation...
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Biochem J (2006) 394 (1): 19–26.
Published: 27 January 2006
... through SMO (Smoothened) and represses the expression of HH target genes such as the transcription factor GLI1 ( gli oma 1 ) as well as PTCH1 . Up-regulation of these genes has been observed in several cancer forms, including basal cell carcinoma, digestive track tumours and small cell lung cancer...