... mitochondrial damage and loss of OMM proteins. Inhibition of the mitochondrial calcium uniporter, MAPK and aconitase activity reversed these changes. aconitase ferric ammonium citrate (FAC) glutamate GSH holo-transferrin (HTF) iron MAPK mitochondria mitochondrial calcium uniporter reactive oxygen...

[email protected] ). 12 10 2005 31 10 2005 7 11 2005 7 11 2005 The Biochemical Society, London 2006 disulphide oxidase activity folding kinetics GSH human serum oxidative folding of hirudin protein disulphideisomerase Nascent disulphide proteins require proper folding...

... are increased during weaning, NOS-3 protein levels are diminished. Western blot analyses have demonstrated that protein nitration is increased in the mammary gland during weaning, but this is limited to a few specific tyrosine-nitrated proteins. Interestingly, inhibition of GSH synthesis at the peak...

... + and a normal intracellular level of GSH. In the presence of the thiol scavenger oxidant, azodicarboxylic acid bis[dimethylamide], at concentrations lethal for G6pd Δ but not for wild-type ES cells, NADPH and GSH in G6pd Δ cells dramatically shift to their oxidized forms. In contrast, wild-type ES cells...

... that Bcl-2 affects glutathione in several cell types. The effects reported include up-regulation of cellular GSH, increased resistance to apoptosis due to a reductive shift of the cellular oxidation reduction potential and redis- tribution of GSH to the nucleus and thus protection against DNA fragmentation...