...Ajay Kumar; Abhik Saha; Vijay K. Verma; Suman Kumar Dhar Helicase loaders are required for the loading of helicases at the vicinity of replication origins. In Helicobacter pylori , Hp0897 has been shown to be a potential helicase loader for replicative helicase (HpDnaB) although it does not show...

...Claire Coderch; Emilio Lence; Antonio Peón; Heather Lamb; Alastair R. Hawkins; Federico Gago; Concepción González-Bello DHQ2 (type II dehydroquinase), which is an essential enzyme in Helicobacter pylori and Mycobacterium tuberculosis and does not have any counterpart in humans, is recognized...

... and bicarbonate, are employed to counteract stomach acidity in pathogens such as Helicobacter pylori . Uptake in the latter is mediated by UreI, a UAC (urea amide channel) family member. In the present paper, we describe the structure and function of UAC Bc , a homologue from Bacillus cereus . The purified...

...Ritesh Kumar; Desirazu N. Rao Helicobacter pylori has a dynamic R-M (restriction–modification) system. It is capable of acquiring new R-M systems from the environment in the form of DNA released from other bacteria or other H. pylori strains. Random mutations in R-M genes can result in non...

...Akira Karasawa; Keiji Mitsui; Masafumi Matsushita; Hiroshi Kanazawa We have previously shown that HPNhaA ( Helicobacter pylori Na + /H + antiporter) forms an oligomer in a native membrane of Escherichia coli , and conformational changes of oligomer occur between monomers of the oligomer during ion...

...Mauro Mileni; Fraser MacMillan; Christos Tziatzios; Klaus Zwicker; Alexander H. Haas; Werner Mäntele; Jörg Simon; C. Roy D. Lancaster The ϵ-proteobacteria Helicobacter pylori and Campylobacter jejuni are both human pathogens. They colonize mucosal surfaces causing severe diseases. The membrane...

...Ruiguang Ge; Rory M. Watt; Xuesong Sun; Julian A. Tanner; Qing-Yu He; Jian-Dong Huang; Hongzhe Sun Hpn is a small cytoplasmic protein found in Helicobacter pylori , which binds Ni 2+ ions with moderate affinity. Consisting of 60 amino acids, the protein is rich in histidine (28 residues, 46.7...

... encoding both type I and type II DAH7P synthases, the pathogen Helicobacter pylori has only a single, type II, enzyme. Recombinant DAH7P synthase from H. pylori was partially solubilized by co-expression with chaperonins GroEL/GroES in E. coli , and purified to homogeneity. The enzyme reaction follows...

...Sara LINDÉN; Jafar MAHDAVI; Jan HEDENBRO; Thomas BORÉN; Ingemar CARLSTEDT Helicobacter pylori causes gastritis, peptic ulcer disease and gastric cancer. The microbe is found in the gastric mucus layer where a pH gradient ranging from acidic in the lumen to neutral at the cell surface is maintained...

... that HU from the human pathogen Helicobacter pylori , which has been implicated in the development of ulcers and gastric cancer, exhibits enhanced thermal stability and distinct DNA substrate specificity. Thermal denaturation of HpyHU ( H. pylori HU) measured by CD spectroscopy yields a melting...

...Nicholas A. GEISSE; Timothy L. COVER; Robert M. HENDERSON; J. Michael EDWARDSON The Helicobacter pylori vacuolating toxin VacA causes several effects on mammalian cells in vitro , including intracellular vacuolation, formation of pores in the plasma membrane and apoptosis. When added to cells, VacA...

... x , Le y , H-type-2, the Tn-antigen, the T-antigen, the sialyl-Le x and sialyl-Le a structures, and the expression of these determinants varies between individuals. At neutral pH, Helicobacter pylori strains expressing BabA (blood-group antigen-binding adhesin) bind Rhesus monkey gastric mucins via...

...Hye Yeon BAEK; Joo Weon LIM; Hyeyoung KIM; Jung Mogg KIM; Joo Sung KIM; Hyun Chae JUNG; Kyung Hwan KIM Helicobacter pylori infection leads to gastroduodenal inflammation, peptic ulceration and gastric carcinoma. Proteomic analysis of the human gastric mucosa from the patients with erosive gastritis...