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Keywords: HigBA
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2.09 Å Resolution structure of E. coli HigBA toxin–antitoxin complex reveals an ordered DNA-binding domain and intrinsic dynamics in antitoxin
Available to PurchasePankaj Vilas Jadhav, Vikrant Kumar Sinha, Saurabh Chugh, Chaithanya Kotyada, Digvijay Bachhav, Ramandeep Singh, Ulli Rothweiler, Mahavir Singh
Journal:
Biochemical Journal
Biochem J (2020) 477 (20): 4001–4019.
Published: 29 October 2020
... and persister cell formation. Escherichia coli HigBA complex belongs to the type II TA systems and consists of a protein toxin called HigB and a protein antitoxin called HigA. The toxin HigB is a ribosome-dependent endoribonuclease that cleaves the translating mRNAs at the ribosome A site. The antitoxin HigA...
Includes: Supplementary data