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Keywords: Janus kinase
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Articles

Constitutive activation of p46JNK2 is indispensable for C/EBPδ induction in the initial stage of adipogenic differentiation

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Joji Kusuyama, Tomokazu Ohnishi, Kenjiro Bandow, Muhammad Subhan Amir, Kaori Shima, Ichiro Semba, Tetsuya Matsuguchi
Journal: Biochemical Journal
Biochem J (2017) 474 (20): 3421–3437.
https://doi.org/10.1042/BCJ20170332
Published: 05 October 2017
... by Portland Press Limited on behalf of the Biochemical Society 2017 adipocytes adipogenesis ATF2 C/EBPδ Janus kinase Excessive energy intake increases fatty mass in white adipose tissue commonly found under the skin and around visceral organs. Fat formation is caused by increased volume...
View article titled, Constitutive activation of p46JNK2 is indispensable for C/EBPδ induction in the initial stage of adipogenic differentiation
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Articles

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses

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Leila N. Varghese, Daniela Ungureanu, Nicholas P. D. Liau, Samuel N. Young, Artem Laktyushin, Henrik Hammaren, Isabelle S. Lucet, Nicos A. Nicola, Olli Silvennoinen, Jeffrey J. Babon, James M. Murphy
Journal: Biochemical Journal
Biochem J (2014) 458 (2): 395–405.
https://doi.org/10.1042/BJ20131516
Published: 14 February 2014
...Leila N. Varghese; Daniela Ungureanu; Nicholas P. D. Liau; Samuel N. Young; Artem Laktyushin; Henrik Hammaren; Isabelle S. Lucet; Nicos A. Nicola; Olli Silvennoinen; Jeffrey J. Babon; James M. Murphy JAK2 (Janus kinase 2) initiates the intracellular signalling cascade downstream of cell surface...
View article titled, Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses
Open the PDF for Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses in another window
Includes: Supplementary data
Articles

A transplanted NPVY sequence in the cytosolic domain of the erythropoietin receptor enhances maturation

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Tal Nahari, Eran Barzilay, Koret Hirschberg, Drorit Neumann
Journal: Biochemical Journal
Biochem J (2008) 410 (2): 409–416.
https://doi.org/10.1042/BJ20071297
Published: 12 February 2008
... with anti-EPO antibodies or with anti-rabbit antibodies. cytosolic domain endoplasmic reticulum erythropoietin receptor Janus kinase NPXY motif vesicular-stomatitis-virus glycoprotein (VSVG) Targeting of newly synthesized proteins to their intracellular destination via the secretory...
View article titled, A transplanted NPVY sequence in the cytosolic domain of the erythropoietin receptor enhances maturation
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Includes: Multimedia, Supplementary data
Articles

Cross-talk between interleukin 1β (IL-1β) and IL-6 signalling pathways: IL-1β selectively inhibits IL-6-activated signal transducer and activator of transcription factor 1 (STAT1) by a proteasome-dependent mechanism

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Xuening SHEN, Zhigang TIAN, Michael J. HOLTZMAN, Bin GAO
Journal: Biochemical Journal
Biochem J (2000) 352 (3): 913–919.
https://doi.org/10.1042/bj3520913
Published: 08 December 2000
... affecting the level of STAT1 or tyrosine phosphorylation of STAT3. Kinase assays in vitro indicated that the inhibition of STAT1 phosphorylation by IL-1β was not due to an upstream blockade of Janus kinase (JAK1 or JAK2) activation. However, pretreatment with the proteasome inhibitor MG132 under conditions...
View article titled, Cross-talk between interleukin 1β (IL-1β) and IL-6 signalling pathways: IL-1β selectively inhibits IL-6-activated signal transducer and activator of transcription factor 1 (STAT1) by a proteasome-dependent mechanism
Open the PDF for Cross-talk between interleukin 1β (IL-1β) and IL-6 signalling pathways: IL-1β selectively inhibits IL-6-activated signal transducer and activator of transcription factor 1 (STAT1) by a proteasome-dependent mechanism in another window
Articles

A single amino acid substitution (Trp666→Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction

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Claude HAAN, Heike M. HERMANNS, Peter C. HEINRICH, Iris BEHRMANN
Journal: Biochemical Journal
Biochem J (2000) 349 (1): 261–266.
https://doi.org/10.1042/bj3490261
Published: 26 June 2000
... that abrogates activation of STAT (signal transducer and activator of transcription) transcription factors and the proliferative response of pro-B-cell transfectants. Moreover, association of the Janus kinase JAK1 is prevented. No signalling of heterodimeric IL-5 receptor (IL-5R)/gp130 chimaeras occurs in COS-7...
View article titled, A single amino acid substitution (Trp666→Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction
Open the PDF for A single amino acid substitution (Trp666→Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction in another window