... cytokine receptor kinase Janus kinase (JAK) pseudokinase The transmission of signals from extracellular stimuli across the plasma membrane via the cytoplasm to the nucleus in eukaryotes principally relies on the post-translational protein modification phosphorylation. Protein kinases, enzymes...

... Janus kinase (JAK) signal transducer and activator of transcription (STAT) steroid steroid-like signalling The dominant role that has been placed upon STAT (signal transducer and activator of transcription) transcription factors in gene activation by cytokines may have obscured other...

... correspondence should be addressed (email [email protected] ). 6 6 2008 14 10 2008 16 10 2008 16 10 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 endocytosis granulocyte colony-stimulating factor (G-CSF) receptor Janus kinase (JAK) signal...

... interleukin-6 (IL-6) Janus kinase (JAK) prostaglandin (PG) signal transducer and activator of transcription (STAT) signal transduction The immediate response of an organism towards inflammatory stimuli is the release of pro-inflammatory cytokines such as TNF (tumour necrosis factor) and IL...

.../β receptor internalization Janus kinase (JAK) signal transducer and activator of transcription (STAT) Type I IFNs (interferons) are helical cytokines with pleiotropic activities that contribute to immediate defence against pathogens, development of adaptive immunity and protective anti...

... STAT isoforms. 1 To whom correspondence should be addressed (email [email protected] ). 27 3 2007 5 4 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 cathepsin G Janus kinase (JAK) proteolysis signal transducer and activator of transcription...

... 2003 The Biochemical Society, London ©2003 2003 cytokine signalling glycoprotein 130 (gp 130) interleukin-6 (IL-6) Janus kinase (JAK) mitogen-activated protein kinase (MAPK) signal transducer and activator of transcription (STAT) Abbreviations used: α 2 M, α 2 -macroglobulin...

... is a signalling receptor for a new cytokine of the IL-10 family. The Biochemical Society, London ©2003 2003 cytokine receptor Janus kinase (JAK) signal transduction signal transducer and activator of transcription (STAT) Abbreviations used: ERK, extracellular-signal-regulated kinase; FCS...

... 2002 5 9 2002 11 9 2002 11 9 2002 The Biochemical Society, London ©2003 2003 DNA-binding protein dominant-negative Stat1α Janus kinase (JAK) Janus kinase inhibitor transcription Abbreviations used: BRE, TFIIB-recognition element; CBP, cAMP-response-element...