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1-7 of 7
Keywords: LKB1
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Articles
Journal:
Biochemical Journal
Biochem J (2024) 481 (8): 587–599.
Published: 22 April 2024
... CBS repeats (CBS1, CBS3, CBS4) on the AMPK-γ subunit activates the kinase complex by three complementary mechanisms: (i) promoting α-subunit Thr172 phosphorylation by the upstream kinase LKB1; (ii) protecting against Thr172 dephosphorylation; (iii) allosteric activation. Surprisingly, binding of ADP...
Includes: Supplementary data
Articles
A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis
Available to PurchaseMhairi C. Towler, Sarah Fogarty, Simon A. Hawley, David A. Pan, David M. A. Martin, Nicolas A. Morrice, Afshan McCarthy, María N. Galardo, Silvina B. Meroni, Selva B. Cigorraga, Alan Ashworth, Kei Sakamoto, D. Grahame Hardie
Journal:
Biochemical Journal
Biochem J (2008) 416 (1): 1–14.
Published: 28 October 2008
...Mhairi C. Towler; Sarah Fogarty; Simon A. Hawley; David A. Pan; David M. A. Martin; Nicolas A. Morrice; Afshan McCarthy; María N. Galardo; Silvina B. Meroni; Selva B. Cigorraga; Alan Ashworth; Kei Sakamoto; D. Grahame Hardie LKB1 was discovered as a tumour suppressor mutated in Peutz-Jeghers...
Includes: Supplementary data
Articles
LKB1: cancer, polarity, metabolism, and now fertility
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2008) 416 (1): e1–e3.
Published: 28 October 2008
...Reuben J. Shaw The LKB1 serine/threonine kinase is a tumour suppressor responsible for the inherited familial cancer disorder Peutz-Jeghers syndrome and is inactivated in a large percentage of human lung cancers. LKB1 acts a master kinase, directly phosphorylating and activating a family of 14 AMPK...
Articles
Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
Available to PurchaseXu Huang, Stephan Wullschleger, Natalia Shpiro, Victoria A. McGuire, Kei Sakamoto, Yvonne L. Woods, Wendy Mcburnie, Stewart Fleming, Dario R. Alessi
Journal:
Biochemical Journal
Biochem J (2008) 412 (2): 211–221.
Published: 14 May 2008
...Xu Huang; Stephan Wullschleger; Natalia Shpiro; Victoria A. McGuire; Kei Sakamoto; Yvonne L. Woods; Wendy Mcburnie; Stewart Fleming; Dario R. Alessi The LKB1 tumour suppressor phosphorylates and activates AMPK (AMP-activated protein kinase) when cellular energy levels are low, thereby suppressing...
Includes: Supplementary data
Articles
Cancer therapy: staying current with AMPK
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2008) 412 (2): e3–e5.
Published: 14 May 2008
...David A. Fruman; Aimee L. Edinger Does the LKB1–AMPK (AMP-activated protein kinase) pathway act to suppress tumorigenesis or to rescue cancer cells from metabolic collapse? New work from the Alessi laboratory in this issue of the Biochemical Journal shows conclusively that AMPK activators delay...
Articles
Control of AMPK-related kinases by USP9X and atypical Lys 29 /Lys 33 -linked polyubiquitin chains
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2008) 411 (2): 249–260.
Published: 27 March 2008
...Abdallah K. Al-Hakim; Anna Zagorska; Louise Chapman; Maria Deak; Mark Peggie; Dario R. Alessi AMPK (AMP-activated protein kinase)-related kinases regulate cell polarity as well as proliferation and are activated by the LKB1-tumour suppressor kinase. In the present study we demonstrate that the AMPK...
Includes: Supplementary data
Articles
Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2007) 403 (1): 139–148.
Published: 13 March 2007
... to detect any effect of AMP on Thr 172 phosphorylation by either LKB1 or CaMKKβ (Ca 2+ /calmodulin-dependent protein kinase kinase β) using recombinant preparations of the proteins. However, using partially purified AMPK from rat liver, there was an apparent AMP-stimulation of Thr 172 phosphorylation...
