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Keywords: Met
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Articles

Targeting epithelial–mesenchymal plasticity in cancer: clinical and preclinical advances in therapy and monitoring

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Sugandha Bhatia, James Monkman, Alan Kie Leong Toh, Shivashankar H. Nagaraj, Erik W. Thompson
Journal: Biochemical Journal
Biochem J (2017) 474 (19): 3269–3306.
https://doi.org/10.1042/BCJ20160782
Published: 20 September 2017
... properties, allowing them to migrate from the primary site. These cells may then exist in a hybrid state as they migrate or re-adopt epithelial traits through a reverse, MET process. Such processes are broadly marked by the regulation of EMP transcription factors (TFs; e.g. SNAI1/2, ZEB1/2 and Twist 1/2/3...
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Articles

Conformation-dependent inactivation of human betaine-homocysteine S-methyltransferase by hydrogen peroxide in vitro

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Catherine M. Miller, Sandra S. Szegedi, Timothy A. Garrow
Journal: Biochemical Journal
Biochem J (2005) 392 (3): 443–448.
https://doi.org/10.1042/BJ20050356
Published: 06 December 2005
...Catherine M. Miller; Sandra S. Szegedi; Timothy A. Garrow Betaine-homocysteine S-methyltransferase (BHMT) transfers a methyl group from betaine to Hcy to form DMG (dimethylglycine) and Met. The reaction is ordered Bi Bi; Hcy is the first substrate to bind and Met is the last product off. Using...
View articletitled, Conformation-dependent inactivation of human betaine-homocysteine S-methyltransferase by hydrogen peroxide in vitro
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Articles

The β-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesis

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Stephen M. RIORDAN, Sukhwinderjit LIDDER, Roger WILLIAMS, George G. SKOUTERIS
Journal: Biochemical Journal
Biochem J (2000) 350 (3): 925–932.
https://doi.org/10.1042/bj3500925
Published: 08 September 2000
.... CrkII was found to be phosphorylated in response to hepatocyte growth factor/scatter factor (HGF/SF) and to associate with the beta-subunit of the HGF receptor (MET). CrkII associated with p 145βMET via its SH2 domain. Growth-factor-receptor-bound protein 2 (Grb2) co-immunoprecipitated with CrkII...
View articletitled, The β-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesis
Open the PDF for The β-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesis in another window