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Keywords: MyD88
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Articles

Sequence rules for a long SPOP-binding degron required for protein ubiquitylation

Open Access
Linda Makhlouf, Mukul Mishra, Hannah Makhlouf, Iain Manfield, Luca Busino, Elton Zeqiraj
Journal: Biochemical Journal
Biochem J (2025) 482 (10): 583–600.
https://doi.org/10.1042/BCJ20253041
Published: 15 May 2025
... response 88 (MyD88), is ubiquitylated by the SPOP-based E3 ligase to negatively regulate immune signaling; however, the sequence rules for SPOP-mediated substrate engagement and degradation are not fully understood. Here, we show that MyD88 interacts with SPOP through a long degron that contains...
View articletitled, Sequence rules for a long SPOP-binding degron required for protein ubiquitylation
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Includes: Supplementary data
Articles

TAK1 protein kinase activity is required for TLR signalling and cytokine production in myeloid cells

Open Access
Melissa Rodrigues, Tsvetana Petrova, Brendan Tibbs, J. Simon C. Arthur, Philip Cohen
Journal: Biochemical Journal
Biochem J (2022) 479 (17): 1891–1907.
https://doi.org/10.1042/BCJ20220314
Published: 16 September 2022
.... immune cell signaling MyD88 toll-like receptors Components of microbial pathogens, termed Pathogen Associated Molecular Patterns (PAMPs), activate Toll-Like Receptors (TLRs) in immune cells, switching on signalling networks that control the production and secretion of inflammatory mediators...
View articletitled, TAK1 protein kinase activity is required for TLR signalling and cytokine production in myeloid cells
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Includes: Supplementary data
Articles

The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists

Open Access
Stefan Vollmer, Sam Strickson, Tinghu Zhang, Nathanael Gray, Katherine L. Lee, Vikram R. Rao, Philip Cohen
Journal: Biochemical Journal
Biochem J (2017) 474 (12): 2027–2038.
https://doi.org/10.1042/BCJ20170097
Published: 06 June 2017
... 26 4 2017 4 5 2017 16 5 2017 © 2017 The Author(s) 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . innate immunity IRAK MyD88 Pellino...
View articletitled, The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists
Open the PDF for The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists in another window
Includes: Supplementary data