... transactivation by MyoD, the strongest myogenic MRF. Including of any one of the other E-boxes restored the full activation by MyoD, suggesting an essential collaboration between E-boxes. Stronger activation of M-cadherin promoter than that of muscle creatine kinase ( MCK ) by MyoD was observed regardless...

..., and there are indications that the muscle may be a relevant site of FGF21 production under conditions of muscular mitochondrial stress. In the present study, we found that expression and release of FGF21 was associated with myogenic differentiation, and we identified MyoD as a major controller of FGF21 gene transcription...

.... Interestingly, most MRFs (myogenic regulatory factors) significantly activated the promoter of M-cadherin, but not that of N-cadherin. In line with this, overexpression of MyoD in C3H10T1/2 fibroblasts strongly induced endogenous M-cadherin expression. Promoter analysis in silico and in vitro identified an E...

... integrated signalling multi-subunit complexes MyoD transcriptional regulation Abbreviations used: DMEM, Dulbecco's modified Eagle's medium; FCS, fetal-calf serum; UTR, untranslated region; ORF, open reading frame; SV40, simian virus 40; MCS, multiple cloning site; DTT, dithiothreitol; PhK...