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Keywords: N-terminal nucleophile hydrolase
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Articles
Biochem J (2005) 385 (2): 565–573.
Published: 07 January 2005
... biosynthesis clavulanic acid β-lactam antibiotic N-terminal nucleophile hydrolase ornithine acetyltransferase Clavulanic acid is a potent inhibitor of class A serine β-lactamases, and is administered clinically in combination with penicillin antibiotics [ 1 ]. It is produced for clinical use...
Articles
Biochem J (2002) 364 (1): 129–136.
Published: 08 May 2002
... often appear to be similar [28]. N-terminal nucleophile hydrolases usually mature via proteolytic processing of single-chain pre- cursors. The newly generated N-terminal amino acid, either a threonine, serine or cysteine, participates both as a base (a- amino group) and also as a nucleophile (side chain...