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Keywords: NAD
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Biochem J (2022) 479 (11): 1165–1180.
Published: 08 June 2022
... microenvironment, facilitate longevity. One such ectoenzyme — the nucleotide pyrophosphatase/phosphodiesterase SmNPP5 can cleave ADP (to prevent platelet aggregation) and NAD (likely preventing Treg apoptosis). A second tegumental ectoenzyme, the glycohydrolase SmNACE, also catabolizes NAD. Here, we undertake...
Biochem J (2011) 433 (3): 505–514.
Published: 14 January 2011
... as an important mechanism for controlling a broad array of proteins mediating cellular adaptation to metabolic fuels. Acetylation is governed, in part, by SIRTs (sirtuins), class III NAD + -dependent deacetylases that regulate lipid and glucose metabolism in liver during fasting and aging. However, the role...
Includes: Supplementary data
Biochem J (2007) 405 (1): 61–67.
Published: 13 June 2007
... biliverdin-IXα reductase (BVR-A) NAD pH optima Xenopus tropicalis The haem catabolic pathway is currently receiving attention in a number of fields with the observation that induction of HO-1 (haem oxygenase-1) is cytoprotective [ 1 , 2 ]. Attempts to relate this to production of the immediate...
Biochem J (2002) 367 (1): 163–168.
Published: 01 October 2002
... phosphatase. The conversion was shown to be stoichiometric. NMN-adenylyltransferase was then used to convert nicotinic acid—adenine dinucleotide into NAD in the presence of high concentrations of NMN. The resultant NAD was amplified by a cycling assay involving alcohol dehydrogenase and diaphorase. Each time...
Biochem J (2002) 366 (1): 265–272.
Published: 15 August 2002
... concentrations. The novel finding, highlighted by specific culture conditions, was a marked NAD depletion in Lesch—Nyhan fibroblasts. ATP and GTP were also 50% of the control, as reported in lymphoblasts. A 6-fold greater incorporation of [ 14 C]nicotinic acid into nicotinic acid— adenine dinucleotide by Lesch...