1-13 of 13
Keywords: NADPH
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Biochem J (2019) 476 (4): 733–746.
Published: 28 February 2019
... human commensal bacteria. IsfD catalyzes the reversible NADPH-dependent reduction of sulfoacetaldehyde, which is generated by transamination of taurine, forming hydroxyethylsulfonate (isethionate) as a waste product. In the present study, the crystal structure of Klebsiella oxytoca IsfD in a ternary...
Includes: Supplementary data
Biochem J (2015) 472 (2): 135–146.
Published: 13 November 2015
... of these groups required for the canonical functions. The key enzyme for these mechanisms is 10-formyl-THF (tetrahydrofolate) dehydrogenase (both mitochondrial and cytoplasmic isoforms) which oxidizes the formyl group to CO 2 with the attendant reduction of NADP + to NADPH and release of THF. In...
Biochem J (2013) 450 (3): 595–605.
Published: 28 February 2013
... this process, 195 putative metabolites, mitochondrial respiration, NADP + , NADPH and insulin secretion were measured within 15 min of stimulation of clonal INS-1 832/13 β-cells with glucose. Rapid responses in the major metabolic pathways of glucose occurred, involving several previously suggested...
Includes: Supplementary data
Biochem J (2009) 419 (2): 411–418.
Published: 27 March 2009
... consumption by a preparation of central glial cells was abolished by cell lysis and recovered by addition of NADPH. NADPH-dependent consumption of NO localized to cell membranes and was inhibited by proteinase K, indicating the involvement of a membrane-bound protein. Purification of this activity yielded...
Includes: Supplementary data
Biochem J (2009) 417 (1): 269–277.
Published: 12 December 2008
... addressed (email jr@sun.ac.za ). 28 5 2008 6 8 2008 12 8 2008 12 8 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 glutathione kinetic modelling NADPH redoxin reductase thiol The redox cycling of redoxins ( Figure 1 ) is a...
Includes: Supplementary data
Biochem J (2007) 403 (1): 197–205.
Published: 13 March 2007
... elevated NAD(P)H autofluorescence in INS-1 cells and islets and increases in assayed NADH and NADPH and the ATP/ADP ratio. Increased NADPH and ATP/ADP ratios occurred more rapidly with MeS, although similar levels were reached after 5 min of exposure to each fuel, whereas NADH increased more with MeS than...
Biochem J (2006) 393 (2): 447–457.
Published: 23 December 2005
... hexachlorophene. Under optimal conditions of pH and ionic strength, Plasmodium falciparum OAR displays kinetic properties similar to those of OAR from bacteria or plants. Activity with NADH is <3% of that with NADPH. Fluorescence enhancement studies indicate that NADPH can bind to the free enzyme, consistent...
Biochem J (2005) 385 (3): 763–768.
Published: 24 January 2005
...Gian F. GAETANI; Anna M. FERRARIS; Paola SANNA; Henry N. KIRKMAN Many catalases have the shared property of containing bound NADPH and being susceptible to inactivation by their own substrate, H 2 O 2 . The presence of additional (unbound) NADPH effectively prevents bovine liver and human...
Biochem J (2005) 385 (1): 75–83.
Published: 14 December 2004
...Barbara PETSCHACHER; Stefan LEITGEB; Kathryn L. KAVANAGH; David K. WILSON; Bernd NIDETZKY CtXR (xylose reductase from the yeast Candida tenuis ; AKR2B5) can utilize NADPH or NADH as co-substrate for the reduction of D -xylose into xylitol, NADPH being preferred approx. 33-fold. X-ray structures of...
Biochem J (2003) 373 (2): 319–326.
Published: 15 July 2003
...Kathryn L. KAVANAGH; Mario KLIMACEK; Bernd NIDETZKY; David K. WILSON Xylose reductase (XR; AKR2B5) is an unusual member of aldo-keto reductase superfamily, because it is one of the few able to efficiently utilize both NADPH and NADH as co-substrates in converting xylose into xylitol. In order to...
Biochem J (2003) 370 (3): 935–943.
Published: 15 March 2003
... in a G6pd -loxed cell line, are unable to produce G6P dehydrogenase (G6PD) protein (EC These G6pd Δ cells proliferate in vitro without special requirements but are extremely sensitive to oxidative stress. Under normal growth conditions, ES G6pd Δ cells show a high ratio of NADPH to NADP...
Biochem J (2002) 364 (2): 349–359.
Published: 01 June 2002
... generation of NADPH. It could therefore be used as a control point of the cellular response to an oxidative stress. Replacement of glucose by galactose sensitized the human epithelial cell line HGT-1 to H 2 O 2 stress. Here we demonstrate that, due to the restricted galactose flux into the PPP, the H 2 O 2...
Biochem J (2001) 353 (2): 245–252.
Published: 08 January 2001
... decreased cellular NADPH concentrations; these effects of glutamine were abolished by DON or azaserine. Restoration of cellular NADPH levels by the addition of 1mM citrate also prevented the inhibiting effect of glutamine or glucosamine on NO synthesis. A further increase in cellular NADPH levels by the...