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Keywords: NRP1
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Articles
EZH2 promotes chemoresistance in colorectal cancer by inhibiting autophagy through NRP1 suppression
Open Access
Journal:
Biochemical Journal
Biochem J (2025) 482 (10): 569–581.
Published: 14 May 2025
... overexpression promoted tumor growth and increased resistance to irinotecan. Mechanistically, EZH2 suppressed autophagy in CRC cells, a process linked to chemosensitivity, by directly regulating LC3bI/II expression. Notably, EZH2 enhanced the neuropilin-1 (NRP1) level by binding to the NRP1 promoter, thereby...
Includes: Supplementary data
