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Keywords: PARP
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Biochem J (2024) 481 (6): 437–460.
Published: 13 March 2024
...Uday Kiran Velagapudi; Élise Rouleau-Turcotte; Ramya Billur; Xuwei Shao; Manisha Patil; Ben E. Black; John M. Pascal; Tanaji T. Talele Catalytic poly(ADP-ribose) production by PARP1 is allosterically activated through interaction with DNA breaks, and PARP inhibitor compounds have the potential...
Includes: Supplementary data
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Biochem J (2022) 479 (4): 463–477.
Published: 17 February 2022
... the Creative Commons Attribution License 4.0 (CC BY) . ADP-ribosylation nucleic acids PARP protein modification ADP-ribosylation is a multifaceted modification of macromolecules that regulates a variety of cellular processes ranging from DNA damage repair, chromatin and telomere-related...
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Biochem J (2021) 478 (23): 4071–4092.
Published: 06 December 2021
... of NAD + -consuming enzymes in the immune defense against viral infections, with the hope that a better understanding of this process could help to develop better antiviral therapeutics targeting these enzymes. These NAD + -consuming enzymes include PARPs, sirtuins, CD38, and SARM1. Among...
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Biochem J (2015) 469 (2): e9–e11.
Published: 06 July 2015
...Péter Bai; Balázs Csóka In this issue of Biochemical Journal , Chen and colleagues characterize an interaction between ACBD3 (acyl-CoA-binding domain-containing 3) protein and PARP [poly(ADP-ribose) polymerase]-1 through the activation of ERKs (extracellular-signal-regulated kinases). This study...