... of the HD into the partially unfolded state (see below), which would stochastically relieve autoinhibition and provide windows of relatively low but physiologically relevant activity [ 29 ]. Interestingly, whilst the HD is also present in PARP4 (also known as vault PARP or vPARP), it does not fully inhibit...

...Uday Kiran Velagapudi; Élise Rouleau-Turcotte; Ramya Billur; Xuwei Shao; Manisha Patil; Ben E. Black; John M. Pascal; Tanaji T. Talele Catalytic poly(ADP-ribose) production by PARP1 is allosterically activated through interaction with DNA breaks, and PARP inhibitor compounds have the potential...

... the Creative Commons Attribution License 4.0 (CC BY) . ADP-ribosylation nucleic acids PARP protein modification The ART fold is structurally highly conserved and binds NAD + in a bent and constrained confirmation. Characteristic for the ART fold are mainly two known conserved three amino acid...

... of NAD + -consuming enzymes in the immune defense against viral infections, with the hope that a better understanding of this process could help to develop better antiviral therapeutics targeting these enzymes. These NAD + -consuming enzymes include PARPs, sirtuins, CD38, and SARM1. Among...

...Péter Bai; Balázs Csóka In this issue of Biochemical Journal , Chen and colleagues characterize an interaction between ACBD3 (acyl-CoA-binding domain-containing 3) protein and PARP [poly(ADP-ribose) polymerase]-1 through the activation of ERKs (extracellular-signal-regulated kinases). This study...