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Keywords: PDZ domain
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Articles
Biochem J (2021) 478 (7): 1321–1332.
Published: 06 April 2021
... immunity. Mutations in Scribble lead to neural tube defects in mice and humans, which has been attributed to a loss of interaction with the planar cell polarity regulator Vangl2. We show that the Scribble PDZ domains 1, 2 and 3 are able to interact with the C-terminal PDZ binding motif of Vangl2 and have...
Includes: Supplementary data
Articles
Biochem J (2015) 468 (1): 133–144.
Published: 05 May 2015
... study, we found that the two PDZ domains within the PDZ34 tandem of Scribble, a cell polarity regulator, tightly pack in a ‘front-to-back’ mode to form a compact supramodule. Although PDZ4 contains a distorted αB/βB pocket, the attachment of PDZ4 to PDZ3 generates an unexpected interdomain pocket that...
Includes: Supplementary data
Articles
Biochem J (2013) 455 (1): 1–14.
Published: 13 September 2013
...Fei Ye; Mingjie Zhang PDZ domains are highly abundant protein–protein interaction modules and are often found in multidomain scaffold proteins. PDZ-domain-containing scaffold proteins regulate multiple biological processes, including trafficking and clustering receptors and ion channels at defined...
Articles
Biochem J (2013) 453 (3): 345–356.
Published: 12 July 2013
...: monoisotopic; peptide mass tolerance, ±100 p.p.m.; fragment mass tolerance, ±0.5 Da; missed cleavages, 1. A blot overlay assay was performed as described previously [ 22 ]. Briefly, His 6 -tagged PDZ domains of PSD95-fusion protein were purified, run on SDS/PAGE (10% gels) and then transferred on to a...
Articles
Biochem J (2012) 444 (3): 457–464.
Published: 29 May 2012
... original work is properly cited. organotypic hippocampal slice culture PDZ domain phosphatase and tensin homologue deleted on chromosome 10 (PTEN) protein phosphatase spine density two-photon laser-scanning microscopy A significant development that facilitated the appreciation of the...
Articles
Biochem J (2011) 439 (2): 195–205.
Published: 28 September 2011
...Vanitha Krishna Subbaiah; Christian Kranjec; Miranda Thomas; Lawrence Banks Over 250 PDZ (PSD95/Dlg/ZO-1) domain-containing proteins have been described in the human proteome. As many of these possess multiple PDZ domains, the potential combinations of associations with proteins that possess PBMs...
Articles
Biochem J (2011) 435 (3): 733–742.
Published: 13 April 2011
... formed different homo-oligomeric complexes with and without substrate, implying mechanistic differences in comparison with each other and with the well-studied Escherichia coli orthologues DegP (degradation of periplasmic proteins P) and DegS. Deletion of the PDZ domain decreased, but did not abolish...
Includes: Supplementary data
Articles
Biochem J (2011) 435 (2): e1–e4.
Published: 29 March 2011
.... On the basis of the number and diversity of PDZ-domain-mediated interactions, we predict that the development of small-molecule compounds which specifically target a particular interaction will continue to be challenging. As the PDZome expands, so will the number of possible protein partnerships that...
Articles
Biochem J (2011) 435 (2): 451–462.
Published: 29 March 2011
... subcellular microdomains to modulate trafficking, transport and signalling in cells. Targeting protein–protein interactions within these macromolecular complexes would affect the expression or function of the CFTR channel. We specifically targeted the PDZ domain-based LPA 2 (type 2 lysophosphatidic acid...
Includes: Supplementary data
Articles
Biochem J (2010) 432 (3): 461–478.
Published: 25 November 2010
... necessary for YAP2 localization in the nucleus and for promoting cell detachment and apoptosis. In the present study, we show that the tight junction protein ZO (zonula occludens)-2 uses its first PDZ domain to form a complex with YAP2. The endogenous ZO-2 and YAP2 proteins co-localize in the nucleus. We...
Includes: Supplementary data
Articles
Biochem J (2004) 381 (3): 895–904.
Published: 27 July 2004
...MURWANTOKO; Masato YANO; Yoshifumi UETA; Ai MURASAKI; Hidenobu KANDA; Chio OKA; Masashi KAWAICHI HtrA1, a member of the mammalian HtrA (high temperature requirement A) serine protease family, has a highly conserved protease domain followed by a PDZ domain. Accumulating evidence has indicated that...
Articles
Biochem J (2003) 372 (2): 465–471.
Published: 01 June 2003
... intracellular signalling molecules. In neurons, neuronal nitric oxide synthase (nNOS) binds selectively to the second PDZ domain (PDZ2) of PSD-95, thereby exhibiting physiological activation triggered via NMDA receptors. We have demonstrated previously that Ca 2+ /calmodulin-dependent protein kinase IIα (CaM-K...
Articles
Biochem J (2002) 368 (1): 1–15.
Published: 15 November 2002
... activation of associated transmembrane receptors. PDZ domain-containing scaffold proteins (syntenin and CASK) bind to the C-terminus of the syndecan-4 cytoplasmic domain and co-ordinate clustering of receptors and connection to the actin cytoskeleton. Syndecan-4 also binds and activates protein kinase Cα in...
Articles
Biochem J (2002) 361 (3): 443–450.
Published: 25 January 2002
... (DRASIC). Their response to acidic pH, their sequence similarity to nematode proteins involved in mechanotransduction and their modulation by neuropeptides suggest that they may function as receptors for a number of different stimuli. Using the yeast two-hybrid assay, we found that the PDZ domain...
Articles
Biochem J (2001) 356 (2): 581–588.
Published: 24 May 2001
... analysis demonstrated that the protein was integrated into the plasma membrane. Overexpression of cDNAs encoding neuroligin 4 and the PDZ-domain protein, PSD-95, in COS-7 cells resulted in the formation of detergent-resistant complexes. Neuroligin 4 did not bind to ZO-1, another PDZ-domain protein...
Articles
Biochem J (2000) 346 (3): 827–833.
Published: 07 March 2000
... Biochemical Society, London © 2000 2000 phosphoinositide signalling phosphatase tumour suppressor PDZ domain Biochem. J. (2000) 346, 827 833 (Printed in Great Britain) 827 Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations : differential effects of C...
Articles
Biochem J (1999) 343 (1): 99–105.
Published: 24 September 1999
... C-terminal kinase fragment of LIMK1 bound to the LIM domain but not to the PDZ domain. Furthermore, the LIM fragment dose-dependently inhibited the kinase catalytic activity of the kinase core fragment of LIMK1. Taken together, these results suggest that the N-terminal LIM domain negatively...