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Keywords: PICALM
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Biochem J (2019) 476 (14): 2093–2109.
Published: 31 July 2019
... be endocytosed from the cell surface. The phosphatidylinositol binding clathrin assembly protein (PICALM) is involved in clathrin-mediated endocytosis and polymorphisms in and near the gene locus were identified as genetic risk factors for AD. PICALM overexpression enhances APP internalization and Aβ production...
Includes: Supplementary data