... of CSC phosphatases and their therapeutic potential in cancer combination therapies. Protein phosphatase 2A (PP2A) is a heterotrimeric protein complex consisting of a catalytic subunit (PP2Ac or C), a scaffold subunit (PR65 or A), and one of the alternative regulatory B subunits ( Figure 1A...

... reticulum (ER)- Ca 2+ signaling that activates transcriptional factor EB (TFEB), a master transcriptional regulator of autophagic and lysosomal biogenesis. Moreover, RSV activates protein phosphatase 2A (PP2A), which binds and dephosphorylates TFEB, promoting its nuclear translocation and the expression...

... that some AMPK processes are uncoupled by CIP2A, likely via its inhibition of protein phosphatase 2A (PP2A). The data demonstrate that AMPK mediates this novel CIP2A effect on energy generation in malignant cells. Correspondence: James A. Austin ( [email protected] ) 28 2 2019 9 7...

...Jin ZHOU; Huong T. PHAM; Ralf RUEDIGER; Gernot WALTER Protein phosphatase 2A (PP2A) is very versatile owing to a large number of regulatory subunits and its ability to interact with numerous other proteins. The regulatory A subunit exists as two closely related isoforms designated Aα and Aβ...

...Timothy MYLES; Karsten SCHMIDT; David R. H. EVANS; Peter CRON; Brian A. HEMMINGS Members of the phosphoprotein phosphatase (PPP) family of protein serine/threonine phosphatases, including protein phosphatase (PP)1, PP2A and PP2B, share invariant active-site residues that are critical for catalytic...

...Veerle JANSSENS; Jozef GORIS Protein phosphatase 2A (PP2A) comprises a family of serine/threonine phosphatases, minimally containing a well conserved catalytic subunit, the activity of which is highly regulated. Regulation is accomplished mainly by members of a family of regulatory subunits, which...