... roles in cell proliferation, migration, and survival. We previously demonstrated that PRLs can post-translationally down-regulate PTEN, a tumor suppressor frequently inactivated in human cancers, by dephosphorylating PTEN at Tyr336, which promotes the NEDD4-mediated PTEN ubiquitination and proteasomal...

... and phosphatidylinositol (3,4,5)-trisphosphate (PTEN). For more detailed biochemistry of phosphatases, characteristics of the phosphatase families, and their broader roles in cancer, the reader is encouraged to study the recent reviews [ 25–28 ]. The soluble ligand WNT induces β-catenin pathway, which...

...-kinase PTEN transmembrane proteins PPIs (polyphosphoinositides) are reversibly phosphorylated derivatives of the membrane phospholipid phosphatidylinositol (PI, Figure 1A ). They are low-abundance lipids of the cytoplasmic leaflet of all eukaryotic cellular membranes. PPIs are amphiphilic...

...Isabel Rodríguez-Escudero; Françoise M. Roelants; Jeremy Thorner; César Nombela; María Molina; Víctor J. Cid The mammalian signalling pathway involving class I PI3K (phosphoinositide 3-kinase), PTEN (phosphatidylinositol 3-phosphatase) and PKB (protein kinase B)/c-Akt has roles in multiple...

...Steven M. WALKER; C. Peter DOWNES; Nick R. LESLIE The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour suppressor is a phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5) P 3 ] 3-phosphatase that plays a critical role in regulating many cellular processes by antagonizing...