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Keywords: PTEN
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Articles
Biochem J (2025) 482 (07): 341–356.
Published: 10 April 2025
... roles in cell proliferation, migration, and survival. We previously demonstrated that PRLs can post-translationally down-regulate PTEN, a tumor suppressor frequently inactivated in human cancers, by dephosphorylating PTEN at Tyr336, which promotes the NEDD4-mediated PTEN ubiquitination and proteasomal...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (14): 2899–2920.
Published: 28 July 2021
... and phosphatidylinositol (3,4,5)-trisphosphate (PTEN). For more detailed biochemistry of phosphatases, characteristics of the phosphatase families, and their broader roles in cancer, the reader is encouraged to study the recent reviews [ 25–28 ]. The soluble ligand WNT induces β-catenin pathway, which...
Articles
Biochem J (2019) 476 (1): 1–23.
Published: 07 January 2019
...-kinase PTEN transmembrane proteins PPIs (polyphosphoinositides) are reversibly phosphorylated derivatives of the membrane phospholipid phosphatidylinositol (PI, Figure 1A ). They are low-abundance lipids of the cytoplasmic leaflet of all eukaryotic cellular membranes. PPIs are amphiphilic...
Articles
Biochem J (2005) 390 (2): 613–623.
Published: 23 August 2005
...Isabel Rodríguez-Escudero; Françoise M. Roelants; Jeremy Thorner; César Nombela; María Molina; Víctor J. Cid The mammalian signalling pathway involving class I PI3K (phosphoinositide 3-kinase), PTEN (phosphatidylinositol 3-phosphatase) and PKB (protein kinase B)/c-Akt has roles in multiple...
Articles
Biochem J (2001) 360 (2): 277–283.
Published: 26 November 2001
...Steven M. WALKER; C. Peter DOWNES; Nick R. LESLIE The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour suppressor is a phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5) P 3 ] 3-phosphatase that plays a critical role in regulating many cellular processes by antagonizing...