.... LRRK2 mutations are linked to Parkinson's Disease (PD). Recent structures of LRRK2 RCKW and a full-length inactive LRRK2 (fl-LRRK2 INACT ) monomer revealed that the kinase domain drives LRRK2 activation. The LRR domain and also an ordered LRR–COR linker, wrap around the C-lobe of the kinase domain...

...Eliona Tsefou; Alison S. Walker; Emily H. Clark; Amy R. Hicks; Christin Luft; Kunitoshi Takeda; Toru Watanabe; Bianca Ramazio; James M. Staddon; Thomas Briston; Robin Ketteler Mitochondrial dysfunction is implicated in Parkinson disease (PD). Mutations in Parkin, an E3 ubiquitin ligase, can cause...

...Anna Tasegian; Francois Singh; Ian G. Ganley; Alastair D. Reith; Dario R. Alessi Much effort has been devoted to the development of selective inhibitors of the LRRK2 as a potential treatment for LRRK2 driven Parkinson's disease. In this study, we first compare the properties of Type I (GSK3357679A...

...Quan Wang; Vanessa Crnković; Christian Preisinger; Judith Stegmüller The regulation of proteasome activity is essential to cellular homeostasis and defects have been implicated in various disorders including Parkinson disease. The F-box protein FBXO7 has been implicated in early-onset parkinsonism...

...Alexia F. Kalogeropulou; Jordana B. Freemantle; Pawel Lis; Edmundo G. Vides; Nicole K. Polinski; Dario R. Alessi Mutations that enhance LRRK2 protein kinase activity cause inherited Parkinson's disease. LRRK2 phosphorylates a group of Rab GTPase proteins, including Rab10 and Rab12, within...

... whether the iron deposition in the pathological area of the Parkinsonian monkey brain was due to an increased iron uptake through the Nramp2 iron transporter. Subsequently, the patho- physiological mechanisms that lead to Parkinson disease can be investigated. This work was supported by a grant, RP3950376...

...Robert A. FURLONG; Yolanda NARAIN; Julia RANKIN; Andreas WYTTENBACH; David C. RUBINSZTEIN Protein aggregates are a neuropathological feature of Huntington's disease and Parkinson's disease. Mutant huntingtin exon 1 with 72 CAG repeats fused to enhanced green fluorescent protein (EGFP) forms...

...Seung R. PAIK; Hyun-Ju SHIN; Ju-Hyun LEE; Chung-Soon CHANG; Jongsun KIM α-Synuclein is a component of the abnormal protein depositions in senile plaques and Lewy bodies of Alzheimer's disease (AD) and Parkinson's disease respectively. The protein was suggested to provide a possible nucleation...