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Keywords: Parkinsons disease
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Biochem J (2023) 480 (11): 815–833.
Published: 12 June 2023
.... LRRK2 mutations are linked to Parkinson's Disease (PD). Recent structures of LRRK2 RCKW and a full-length inactive LRRK2 (fl-LRRK2 INACT ) monomer revealed that the kinase domain drives LRRK2 activation. The LRR domain and also an ordered LRR–COR linker, wrap around the C-lobe of the kinase domain...
Includes: Supplementary data
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Biochem J (2021) 478 (23): 4099–4118.
Published: 06 December 2021
...Eliona Tsefou; Alison S. Walker; Emily H. Clark; Amy R. Hicks; Christin Luft; Kunitoshi Takeda; Toru Watanabe; Bianca Ramazio; James M. Staddon; Thomas Briston; Robin Ketteler Mitochondrial dysfunction is implicated in Parkinson disease (PD). Mutations in Parkin, an E3 ubiquitin ligase, can cause...
Includes: Supplementary data
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Biochem J (2021) 478 (19): 3555–3573.
Published: 06 October 2021
...Anna Tasegian; Francois Singh; Ian G. Ganley; Alastair D. Reith; Dario R. Alessi Much effort has been devoted to the development of selective inhibitors of the LRRK2 as a potential treatment for LRRK2 driven Parkinson's disease. In this study, we first compare the properties of Type I (GSK3357679A...
Includes: Supplementary data
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Articles
Biochem J (2020) 477 (22): 4397–4423.
Published: 27 November 2020
...Alexia F. Kalogeropulou; Jordana B. Freemantle; Pawel Lis; Edmundo G. Vides; Nicole K. Polinski; Dario R. Alessi Mutations that enhance LRRK2 protein kinase activity cause inherited Parkinson's disease. LRRK2 phosphorylates a group of Rab GTPase proteins, including Rab10 and Rab12, within...
Includes: Supplementary data
Articles
Biochem J (2000) 349 (1): 289–297.
Published: 26 June 2000
... monkey brain was due to an increased iron uptake through the Nramp2 iron transporter. Subsequently, the patho- physiological mechanisms that lead to Parkinson disease can be investigated. This work was supported by a grant, RP3950376, from the National University of Singapore. L. Z. is a recipient...
Articles
Biochem J (2000) 346 (3): 577–581.
Published: 07 March 2000
...Robert A. FURLONG; Yolanda NARAIN; Julia RANKIN; Andreas WYTTENBACH; David C. RUBINSZTEIN Protein aggregates are a neuropathological feature of Huntington's disease and Parkinson's disease. Mutant huntingtin exon 1 with 72 CAG repeats fused to enhanced green fluorescent protein (EGFP) forms...
Articles
Biochem J (1999) 340 (3): 821–828.
Published: 08 June 1999
...Seung R. PAIK; Hyun-Ju SHIN; Ju-Hyun LEE; Chung-Soon CHANG; Jongsun KIM α-Synuclein is a component of the abnormal protein depositions in senile plaques and Lewy bodies of Alzheimer's disease (AD) and Parkinson's disease respectively. The protein was suggested to provide a possible nucleation...