Page 1 | Search Results | Biochemical Journal

1-34 of 34

Sort by

Sort Order Select

Articles

A Plasmodium falciparum ubiquitin-specific protease ( Pf USP) is essential for parasite survival and its disruption enhances artemisinin efficacy

Priya Arora, Monika Narwal, Vandana Thakur, Osama Mukhtar, Pawan Malhotra, Asif Mohmmed

Biochem J (2023) 480 (1): 25–39.

https://doi.org/10.1042/BCJ20220429

Published: 06 January 2023

.... In this study, we have characterized the biochemical and functional role of a novel ubiquitin-specific protease (USP) domain-containing protein of the human malaria parasite Plasmodium falciparum ( Pf USP). We have shown that the Pf USP is an active deubiquitinase associated with parasite endoplasmic reticulum...

View article titled, A Plasmodium falciparum ubiquitin-specific protease ( Pf USP) is essential for parasite survival and its disruption enhances artemisinin efficacy

Includes: Supplementary data

Articles

Nanobodies against Pfs230 block Plasmodium falciparum transmission

Melanie H. Dietrich, Mikha Gabriela, Kitsanapong Reaksudsan, Matthew W. A. Dixon, Li-Jin Chan, Amy Adair, Stephanie Trickey, Matthew T. O'Neill, Li Lynn Tan, Sash Lopaticki, Julie Healer, Sravya Keremane, Alan F. Cowman, Wai-Hong Tham

Biochem J (2022) 479 (24): 2529–2546.

https://doi.org/10.1042/BCJ20220554

Published: 22 December 2022

... Plasmodium falciparum Sexual stage development of Plasmodium falciparum is essential for the transmission of the malaria parasite from mosquito to human. When a female Anopheles mosquito takes a blood meal, gametocytes, which are the sexual forms of the malaria parasites, are taken up...

View article titled, Nanobodies against Pfs230 block Plasmodium falciparum transmission

Includes: Supplementary data

Articles

Glm S mediated knock-down of a phospholipase expedite alternate pathway to generate phosphocholine required for phosphatidylcholine synthesis in Plasmodium falciparum

Pradeep Kumar Sheokand, Monika Narwal, Vandana Thakur, Asif Mohmmed

Biochem J (2021) 478 (18): 3429–3444.

https://doi.org/10.1042/BCJ20200549

Published: 23 September 2021

... the Kennedy pathway. The phosphocholine required for this synthetic pathway is generated by phosphorylation of choline derived from the catabolism of the lyso-phosphatidylcholine (LPC) scavenged from the host milieu. Here we have characterized a Plasmodium falciparum lysophospholipase ( Pf LPL20) which showed...

View article titled, Glm S mediated knock-down of a phospholipase expedite alternate pathway to generate phosphocholine required for phosphatidylcholine synthesis in Plasmodium falciparum

Includes: Multimedia, Supplementary data

Articles

Plasmodium falciparum Atg18 localizes to the food vacuole via interaction with the multi-drug resistance protein 1 and phosphatidylinositol 3-phosphate

Renu Sudhakar, Divya Das, Subramanian Thanumalayan, Somesh Gorde, Puran Singh Sijwali

Biochem J (2021) 478 (9): 1705–1732.

https://doi.org/10.1042/BCJ20210001

Published: 10 May 2021

... investigated Plasmodium falciparum Atg18 (PfAtg18), a PROPPIN family protein, whose members like S. cerevisiae Atg18 (ScAtg18) and human WIPI2 bind PI3P and play an essential role in autophagosome formation. Wild type and mutant PfAtg18 were expressed in P. falciparum and assessed for localization, the effect...

View article titled, Plasmodium falciparum Atg18 localizes to the food vacuole via interaction with the multi-drug resistance protein 1 and phosphatidylinositol 3-phosphate

Includes: Supplementary data

Articles

Molecular dynamics simulations and biochemical characterization of Pf 14-3-3 and Pf CDPK1 interaction towards its role in growth of human malaria parasite

Ravi Jain, Pinki Dey, Sakshi Gupta, Soumya Pati, Arnab Bhattacherjee, Manoj Munde, Shailja Singh

Biochem J (2020) 477 (12): 2153–2177.

https://doi.org/10.1042/BCJ20200145

Published: 22 June 2020

... PF3D7_0818200 as 14-3-3 isoform I in Plasmodium falciparum 3D7, and its interaction with one of the key kinases of the parasite, Calcium-Dependent Protein Kinase 1 (CDPK1) by performing various analytical biochemistry and biophysical assays. Molecular dynamics simulation studies indicated that CDPK1 polypeptide...

View article titled, Molecular dynamics simulations and biochemical characterization of Pf 14-3-3 and Pf CDPK1 interaction towards its role in growth of human malaria parasite

Includes: Multimedia, Supplementary data

Articles

Development of novel anti-malarial from structurally diverse library of molecules, targeting plant-like CDPK1, a multistage growth regulator of P. falciparum

Ravi Jain, Sakshi Gupta, Manoj Munde, Soumya Pati, Shailja Singh

Biochem J (2020) 477 (10): 1951–1970.

https://doi.org/10.1042/BCJ20200045

Published: 29 May 2020

...Ravi Jain; Sakshi Gupta; Manoj Munde; Soumya Pati; Shailja Singh Upon Plasmodium falciparum merozoites exposure to low [K + ] environment in blood plasma, there is escalation of cytosolic [Ca 2+ ] which activates Ca 2+ -Dependent Protein Kinase 1 (CDPK1), a signaling hub of intra-erythrocytic...

View article titled, Development of novel anti-malarial from structurally diverse library of molecules, targeting plant-like CDPK1, a multistage growth regulator of P. falciparum

Includes: Supplementary data

Articles

A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1

Sarah J. Tarr, Chrislaine Withers-Martinez, Helen R. Flynn, Ambrosius P. Snijders, Laura Masino, Konstantinos Koussis, David J. Conway, Michael J. Blackman

Biochem J (2020) 477 (2): 525–540.

https://doi.org/10.1042/BCJ20190918

Published: 31 January 2020

... of the propeptide of SUB1, an essential parasite subtilase that is discharged into the parasitophorous vacuole (PV) to trigger parasite release (egress) from infected host cells. Recombinant Plasmodium falciparum SUB1-ProM was found to be a fast-binding, potent inhibitor of P. falciparum SUB1, but not of the only...

View article titled, A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1

Includes: Supplementary data

Articles

Two insulin-like peptides differentially regulate malaria parasite infection in the mosquito through effects on intermediary metabolism

Jose E. Pietri, Nazzy Pakpour, Eleonora Napoli, Gyu Song, Eduardo Pietri, Rashaun Potts, Kong W. Cheung, Gregory Walker, Michael A. Riehle, Hannah Starcevich, Cecilia Giulivi, Edwin E. Lewis, Shirley Luckhart

Biochem J (2016) 473 (20): 3487–3503.

https://doi.org/10.1042/BCJ20160271

Published: 11 October 2016

... with these studies, we previously showed that knockdown of either of two closely related, infection-induced ILPs, ILP3 and ILP4, in the mosquito Anopheles stephensi decreased infection with the human malaria parasite Plasmodium falciparum through kinetically distinct effects on parasite death. However, the precise...

View article titled, Two insulin-like peptides differentially regulate malaria parasite infection in the mosquito through effects on intermediary metabolism

Includes: Supplementary data

Articles

Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum

Nyssa Drinkwater, Komagal Kannan Sivaraman, Rebecca S. Bamert, Wioletta Rut, Khadija Mohamed, Natalie B. Vinh, Peter J. Scammells, Marcin Drag, Sheena McGowan

Biochem J (2016) 473 (19): 3189–3204.

https://doi.org/10.1042/BCJ20160550

Published: 27 September 2016

... metalloaminopeptidases, including aminopeptidase P (APP). We developed a novel platform to examine the substrate fingerprint of APP from Plasmodium falciparum ( Pf APP) and to show that it can catalyze the removal of any residue immediately prior to a proline. Further, we have determined the crystal structure of Pf APP...

View article titled, Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum

Includes: Supplementary data

Articles

Functional dissection of proliferating-cell nuclear antigens (1 and 2) in human malarial parasite Plasmodium falciparum: possible involvement in DNA replication and DNA damage response

Pallabi Mitra, Khadija Banu, Abhijit S. Deshmukh, Naidu Subbarao, Suman Kumar Dhar

Biochem J (2015) 470 (1): 115–129.

https://doi.org/10.1042/BJ20150452

Published: 06 August 2015

...Pallabi Mitra; Khadija Banu; Abhijit S. Deshmukh; Naidu Subbarao; Suman Kumar Dhar Eukaryotic PCNAs (proliferating-cell nuclear antigens) play diverse roles in nucleic acid metabolism in addition to DNA replication. Plasmodium falciparum , which causes human malaria, harbours two PCNA homologues...

View article titled, Functional dissection of proliferating-cell nuclear antigens (1 and 2) in human malarial parasite Plasmodium falciparum: possible involvement in DNA replication and DNA damage response

Includes: Multimedia, Supplementary data

Articles

Plasmodium falciparum mitochondria import tRNAs along with an active phenylalanyl-tRNA synthetase

Arvind Sharma, Amit Sharma

Biochem J (2015) 465 (3): 459–469.

https://doi.org/10.1042/BJ20140998

Published: 22 January 2015

...Arvind Sharma; Amit Sharma The Plasmodium falciparum protein translation enzymes aminoacyl-tRNA synthetases (aaRSs) are an emergent family of drug targets. The aaRS ensemble catalyses transfer of amino acids to cognate tRNAs, thus providing charged tRNAs for ribosomal consumption. P. falciparum...

View article titled, Plasmodium falciparum mitochondria import tRNAs along with an active phenylalanyl-tRNA synthetase

Includes: Supplementary data

Articles

From crystal to compound: structure-based antimalarial drug discovery

Nyssa Drinkwater, Sheena McGowan

Biochem J (2014) 461 (3): 349–369.

https://doi.org/10.1042/BJ20140240

Published: 10 July 2014

... Plasmodium falciparum structural biology There are few diseases of today's society that can claim the ancient origins owned by malaria, and yet it remains a major impact on world health. It was first described as a disease in China, 2500–2600 BCE [ 1 ], but the parasite itself predates human...

View article titled, From crystal to compound: structure-based antimalarial drug discovery

Articles

Membrane transport in the malaria parasite and its host erythrocyte

Kiaran Kirk, Adele M. Lehane

Biochem J (2014) 457 (1): 1–18.

https://doi.org/10.1042/BJ20131007

Published: 10 December 2013

...’ electrophysiological studies of infected erythrocytes (i.e. measurements of the total electrical current flowing across the erythrocyte membrane) have revealed the presence in the membrane of Plasmodium falciparum -infected erythrocytes of several different ion conductances that are not seen in uninfected cells under...

View article titled, Membrane transport in the malaria parasite and its host erythrocyte

Articles

Specific phosphorylation of the Pf Rh2b invasion ligand of Plasmodium falciparum

Klemens Engelberg, Aditya S. Paul, Boris Prinz, Maya Kono, Wilhelm Ching, Dorothee Heincke, Thomas Dobner, Tobias Spielmann, Manoj T. Duraisingh, Tim-Wolf Gilberger

Biochem J (2013) 452 (3): 457–466.

https://doi.org/10.1042/BJ20121694

Published: 31 May 2013

...Klemens Engelberg; Aditya S. Paul; Boris Prinz; Maya Kono; Wilhelm Ching; Dorothee Heincke; Thomas Dobner; Tobias Spielmann; Manoj T. Duraisingh; Tim-Wolf Gilberger Red blood cell invasion by the malaria parasite Plasmodium falciparum relies on a complex protein network that uses low and high...

View article titled, Specific phosphorylation of the Pf Rh2b invasion ligand of Plasmodium falciparum

Includes: Supplementary data

Articles

Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite Plasmodium falciparum

Shaun B. Reeksting, Ingrid B. Müller, Pieter B. Burger, Emmanuel S. Burgos, Laurent Salmon, Abraham I. Louw, Lyn-Marie Birkholtz, Carsten Wrenger

Biochem J (2013) 449 (1): 175–187.

https://doi.org/10.1042/BJ20120925

Published: 07 December 2012

...Shaun B. Reeksting; Ingrid B. Müller; Pieter B. Burger; Emmanuel S. Burgos; Laurent Salmon; Abraham I. Louw; Lyn-Marie Birkholtz; Carsten Wrenger Malaria tropica is a devastating infectious disease caused by Plasmodium falciparum . This parasite synthesizes vitamin B 6 de novo via the PLP...

View article titled, Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite Plasmodium falciparum

Includes: Supplementary data

Articles

The antioxidative effect of de novo generated vitamin B 6 in Plasmodium falciparum validated by protein interference

Julia Knöckel, Ingrid B. Müller, Sabine Butzloff, Bärbel Bergmann, Rolf D. Walter, Carsten Wrenger

Biochem J (2012) 443 (2): 397–405.

https://doi.org/10.1042/BJ20111542

Published: 27 March 2012

...Julia Knöckel; Ingrid B. Müller; Sabine Butzloff; Bärbel Bergmann; Rolf D. Walter; Carsten Wrenger The malaria parasite Plasmodium falciparum is able to synthesize de novo PLP (pyridoxal 5′-phosphate), the active form of vitamin B 6 . In the present study, we have shown that the de novo synthesized...

View article titled, The antioxidative effect of de novo generated vitamin B 6 in Plasmodium falciparum validated by protein interference

Articles

Structural basis for the efficient phosphorylation of AZT-MP (3′-azido-3′-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase

Jean L. Whittingham, Juana Carrero-Lerida, James A. Brannigan, Luis M. Ruiz-Perez, Ana P. G. Silva, Mark J. Fogg, Anthony J. Wilkinson, Ian H. Gilbert, Keith S. Wilson, Dolores González-Pacanowska

Biochem J (2010) 428 (3): 499–509.

https://doi.org/10.1042/BJ20091880

Published: 27 May 2010

...Jean L. Whittingham; Juana Carrero-Lerida; James A. Brannigan; Luis M. Ruiz-Perez; Ana P. G. Silva; Mark J. Fogg; Anthony J. Wilkinson; Ian H. Gilbert; Keith S. Wilson; Dolores González-Pacanowska Plasmodium falciparum is the causative agent of malaria, a disease where new drug targets are required...

View article titled, Structural basis for the efficient phosphorylation of AZT-MP (3′-azido-3′-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase

Includes: Supplementary data

Articles

Comparison of the cellular and biochemical properties of Plasmodium falciparum choline and ethanolamine kinases

Blandine Alberge, Leila Gannoun-Zaki, Céline Bascunana, Christophe Tran van Ba, Henri Vial, Rachel Cerdan

Biochem J (2010) 425 (1): 149–163.

https://doi.org/10.1042/BJ20091119

Published: 14 December 2009

...Blandine Alberge; Leila Gannoun-Zaki; Céline Bascunana; Christophe Tran van Ba; Henri Vial; Rachel Cerdan The proliferation of the malaria-causing parasite Plasmodium falciparum within the erythrocyte is concomitant with massive phosphatidylcholine and phosphatidylethanolamine biosynthesis. Based...

View article titled, Comparison of the cellular and biochemical properties of Plasmodium falciparum choline and ethanolamine kinases

Includes: Supplementary data

Articles

A comprehensive model of purine uptake by the malaria parasite Plasmodium falciparum : identification of four purine transport activities in intraerythrocytic parasites

Neils B. Quashie, Dominique Dorin-Semblat, Patrick G. Bray, Giancarlo A. Biagini, Christian Doerig, Lisa C. Ranford-Cartwright, Harry P. De Koning

Biochem J (2008) 411 (2): 287–295.

https://doi.org/10.1042/BJ20071460

Published: 27 March 2008

...Neils B. Quashie; Dominique Dorin-Semblat; Patrick G. Bray; Giancarlo A. Biagini; Christian Doerig; Lisa C. Ranford-Cartwright; Harry P. De Koning Plasmodium falciparum is incapable of de novo purine biosynthesis, and is absolutely dependent on transporters to salvage purines from the environment...

View article titled, A comprehensive model of purine uptake by the malaria parasite Plasmodium falciparum : identification of four purine transport activities in intraerythrocytic parasites

Includes: Supplementary data

Articles

Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum

Paul W. Bowyer, Ruwani S. Gunaratne, Munira Grainger, Chrislaine Withers-Martinez, Sasala R. Wickramsinghe, Edward W. Tate, Robin J. Leatherbarrow, Katherine A. Brown, Anthony A. Holder, Deborah F. Smith

Biochem J (2007) 408 (2): 173–180.

https://doi.org/10.1042/BJ20070692

Published: 14 November 2007

...Paul W. Bowyer; Ruwani S. Gunaratne; Munira Grainger; Chrislaine Withers-Martinez; Sasala R. Wickramsinghe; Edward W. Tate; Robin J. Leatherbarrow; Katherine A. Brown; Anthony A. Holder; Deborah F. Smith Recombinant N-myristoyltransferase of Plasmodium falciparum (termed PfNMT) has been used...

View article titled, Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum

Includes: Supplementary data

Articles

Evaluation of pH during cytostomal endocytosis and vacuolar catabolism of haemoglobin in Plasmodium falciparum

Nectarios Klonis, Olivia Tan, Katherine Jackson, Daniel Goldberg, Michael Klemba, Leann Tilley

Biochem J (2007) 407 (3): 343–354.

https://doi.org/10.1042/BJ20070934

Published: 12 October 2007

...Nectarios Klonis; Olivia Tan; Katherine Jackson; Daniel Goldberg; Michael Klemba; Leann Tilley The DV (digestive vacuole) of the malaria parasite, Plasmodium falciparum , is the site of Hb (haemoglobin) digestion and haem detoxification and, as a consequence, the site of action of CQ (chloroquine...

View article titled, Evaluation of pH during cytostomal endocytosis and vacuolar catabolism of haemoglobin in Plasmodium falciparum

Includes: Supplementary data

Articles

Selective permeabilization of the host cell membrane of Plasmodium falciparum -infected red blood cells with streptolysin O and equinatoxin II

Katherine E. Jackson, Tobias Spielmann, Eric Hanssen, Akinola Adisa, Frances Separovic, Matthew W. A. Dixon, Katharine R. Trenholme, Paula L. Hawthorne, Don L. Gardiner, Tim Gilberger, Leann Tilley

Biochem J (2007) 403 (1): 167–175.

https://doi.org/10.1042/BJ20061725

Published: 13 March 2007

...Katherine E. Jackson; Tobias Spielmann; Eric Hanssen; Akinola Adisa; Frances Separovic; Matthew W. A. Dixon; Katharine R. Trenholme; Paula L. Hawthorne; Don L. Gardiner; Tim Gilberger; Leann Tilley Plasmodium falciparum develops within the mature RBCs (red blood cells) of its human host in a PV...

View article titled, Selective permeabilization of the host cell membrane of Plasmodium falciparum -infected red blood cells with streptolysin O and equinatoxin II

Includes: Multimedia, Supplementary data

Articles

The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization

John M. Pisciotta, Isabelle Coppens, Abhai K. Tripathi, Peter F. Scholl, Joel Shuman, Sunil Bajad, Vladimir Shulaev, David J. Sullivan, Jr

Biochem J (2007) 402 (1): 197–204.

https://doi.org/10.1042/BJ20060986

Published: 25 January 2007

... lipid predominant nanospheres, which envelop haemozoin inside Plasmodium falciparum digestive vacuoles. Subcellular fractionation of parasite-derived haemozoin through a dense 1.7 M sucrose cushion identifies monoacylglycerol and diacylglycerol neutral lipids as well as some polar lipids in close...

View article titled, The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization

Includes: Supplementary data

Articles

Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum , a key enzyme in fatty acid biosynthesis

Sasala R. Wickramasinghe, Kirstine A. Inglis, Jonathan E. Urch, Sylke Müller, Daan M. F. van Aalten, Alan H. Fairlamb

Biochem J (2006) 393 (2): 447–457.

https://doi.org/10.1042/BJ20050832

Published: 23 December 2005

... by hexachlorophene. Under optimal conditions of pH and ionic strength, Plasmodium falciparum OAR displays kinetic properties similar to those of OAR from bacteria or plants. Activity with NADH is <3% of that with NADPH. Fluorescence enhancement studies indicate that NADPH can bind to the free enzyme, consistent...

View article titled, Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum , a key enzyme in fatty acid biosynthesis

Articles

Identification, molecular cloning and functional characterization of an octaprenyl pyrophosphate synthase in intra-erythrocytic stages of Plasmodium falciparum

Renata Tonhosolo, Fabio L. D'Alexandri, Fernando A. Genta, Gerhard Wunderlich, Fabio C. Gozzo, Marcos N. Eberlin, Valnice J. Peres, Emilia A. Kimura, Alejandro M. Katzin

Biochem J (2005) 392 (1): 117–126.

https://doi.org/10.1042/BJ20050441

Published: 08 November 2005

..., carotenoids in plants, and ubiquinones. Significant differences occur in the length of the isoprenic side chains of ubiquinone between different organisms, suggesting that different enzymes are involved in the synthesis of these side chains. Whereas in Plasmodium falciparum the isoprenic side chains...

View article titled, Identification, molecular cloning and functional characterization of an octaprenyl pyrophosphate synthase in intra-erythrocytic stages of Plasmodium falciparum

Articles

Localization of ferrochelatase in Plasmodium falciparum

Sundaramurthy VARADHARAJAN, B. K. Chandrashekar SAGAR, Pundi N. RANGARAJAN, Govindarajan PADMANABAN

Biochem J (2004) 384 (2): 429–436.

https://doi.org/10.1042/BJ20040952

Published: 23 November 2004

...Sundaramurthy VARADHARAJAN; B. K. Chandrashekar SAGAR; Pundi N. RANGARAJAN; Govindarajan PADMANABAN Our previous studies have demonstrated de novo haem biosynthesis in the malarial parasite ( Plasmodium falciparum and P. berghei ). It has also been shown that the first enzyme of the pathway...

View article titled, Localization of ferrochelatase in Plasmodium falciparum

Articles

‘FAS’t inhibition of malaria

Avadhesha SUROLIA, T. N. C. RAMYA, V. RAMYA, Namita SUROLIA

Biochem J (2004) 383 (3): 401–412.

https://doi.org/10.1042/BJ20041051

Published: 26 October 2004

... The Biochemical Society, London 2004 antimalarial apicoplast fatty acid biosynthesis pathway malaria Plasmodium falciparum triclosan “With rings on her fingers and (death) bells on her toes…” Banbury Cross nursery rhyme Be it in the marshy areas of age-old Rome or in the thickets...

View article titled, ‘FAS’t inhibition of malaria

Articles

Slow-tight-binding inhibition of enoyl-acyl carrier protein reductase from Plasmodium falciparum by triclosan

Mili KAPOOR, C. Chandramouli REDDY, M. V. KRISHNASASTRY, Namita SUROLIA, Avadhesha SUROLIA

Biochem J (2004) 381 (3): 719–724.

https://doi.org/10.1042/BJ20031821

Published: 27 July 2004

... elongation step in the type II fatty acid biosynthesis pathway. The malarial parasite Plasmodium falciparum also harbours the genes and is capable of synthesizing fatty acids by utilizing the enzymes of type II FAS (fatty acid synthase). The basic differences in the enzymes of type I FAS, present in humans...

View article titled, Slow-tight-binding inhibition of enoyl-acyl carrier protein reductase from Plasmodium falciparum by triclosan

Articles

Heparan sulphate identified on human erythrocytes: a Plasmodium falciparum receptor

Anna M. VOGT, Gerhard WINTER, Mats WAHLGREN, Dorothe SPILLMANN

Biochem J (2004) 381 (3): 593–597.

https://doi.org/10.1042/BJ20040762

Published: 27 July 2004

...Anna M. VOGT; Gerhard WINTER; Mats WAHLGREN; Dorothe SPILLMANN HS (heparan sulphate) has hitherto not been found on human red blood cells (RBCs, erythrocytes). However, malarial-parasite ( Plasmodium falciparum )-infected RBCs adhere to uninfected RBCs via HS-like receptors. In the present paper we...

View article titled, Heparan sulphate identified on human erythrocytes: a Plasmodium falciparum receptor

Articles

Copper pathways in Plasmodium falciparum infected erythrocytes indicate an efflux role for the copper P-ATPase

Dominique RASOLOSON, Lirong SHI, Curtis R. CHONG, Bjorn F. KAFSACK, David J. SULLIVAN, Jr

Biochem J (2004) 381 (3): 803–811.

https://doi.org/10.1042/BJ20040335

Published: 27 July 2004

...-dimethyl-4,7-diphenyl-1,10-phenanthrolinedisulphonic acid), an extracellular copper chelator, has no effect on parasite growth. We characterized a single copy PfCuP-ATPase ( Plasmodium falciparum copper P-ATPase) transporter, which, like the Crypto-sporidium parvum copper P-ATPase, has a single copper...

View article titled, Copper pathways in Plasmodium falciparum infected erythrocytes indicate an efflux role for the copper P-ATPase

Articles

Characterization of the lipid-binding domain of the Plasmodium falciparum CTP:phosphocholine cytidylyltransferase through synthetic-peptide studies

Marie-Pierre LARVOR, Rachel CERDAN, Catherine GUMILA, Luc MAURIN, Patrick SETA, Claude ROUSTAN, Henri VIAL

Biochem J (2003) 375 (3): 653–661.

https://doi.org/10.1042/bj20031011

Published: 01 November 2003

... which are regulated by reversible membrane interaction. To assess the role of the putative membrane-binding domain of Plasmodium falciparum CCT (PfCCT), we synthesized three peptides, K21, V20 and K54 corresponding to residues 274–294, 308–327 and 274–327 of PfCCT respectively. Conformational behaviour...

View article titled, Characterization of the lipid-binding domain of the Plasmodium falciparum CTP:phosphocholine cytidylyltransferase through synthetic-peptide studies

Articles

The role of two novel regulatory sites in the activation of the cGMP-dependent protein kinase from Plasmodium falciparum

Wensheng DENG, Asha PARBHU-PATEL, David J. MEYER, David A. BAKER

Biochem J (2003) 374 (2): 559–565.

https://doi.org/10.1042/bj20030474

Published: 01 September 2003

...Wensheng DENG; Asha PARBHU-PATEL; David J. MEYER; David A. BAKER The Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) uniquely contains three cGMP binding sites, but also has a ‘degenerate’ fourth site. The role of each cGMP-binding site in PfPKG activation remains unknown. We have...

View article titled, The role of two novel regulatory sites in the activation of the cGMP-dependent protein kinase from Plasmodium falciparum

Articles

The cyclic dipeptide CI-4 [cyclo-(l-Arg-d-Pro)] inhibits family 18 chitinases by structural mimicry of a reaction intermediate

Douglas R. HOUSTON, Ian EGGLESTON, Bj⊘rnar SYNSTAD, Vincent G.H. EIJSINK, Daan M.F. van AALTEN

Biochem J (2002) 368 (1): 23–27.

https://doi.org/10.1042/bj20021034

Published: 15 November 2002

... correspondence should be addressed (e-mail [email protected] ). 2 7 2002 2 9 2002 26 9 2002 26 9 2002 The Biochemical Society, London ©2002 2002 allosamidin Candida albicans glycoside hydrolase Plasmodium falciparum X-ray crystallography...

View article titled, The cyclic dipeptide CI-4 [cyclo-(l-Arg-d-Pro)] inhibits family 18 chitinases by structural mimicry of a reaction intermediate

Articles

Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials

Paul LORIA, Susanne MILLER, Michael FOLEY, Leann TILLEY

Biochem J (1999) 339 (2): 363–370.

https://doi.org/10.1042/bj3390363

Published: 08 April 1999

... of an equimolar concentration of H 2 O 2 . We have analysed the fate of haem molecules in Plasmodium falciparum -infected erythrocytes and have found that only about one third of the haem is polymerized to form haemozoin. The remainder appears to be degraded by a non-enzymic process which leads to an accumulation...

View article titled, Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials

NARROW

Filters

A Plasmodium falciparum ubiquitin-specific protease ( Pf USP) is essential for parasite survival and its disruption enhances artemisinin efficacy

Nanobodies against Pfs230 block Plasmodium falciparum transmission

Glm S mediated knock-down of a phospholipase expedite alternate pathway to generate phosphocholine required for phosphatidylcholine synthesis in Plasmodium falciparum

Plasmodium falciparum Atg18 localizes to the food vacuole via interaction with the multi-drug resistance protein 1 and phosphatidylinositol 3-phosphate

Molecular dynamics simulations and biochemical characterization of Pf 14-3-3 and Pf CDPK1 interaction towards its role in growth of human malaria parasite

Development of novel anti-malarial from structurally diverse library of molecules, targeting plant-like CDPK1, a multistage growth regulator of P. falciparum

A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1

Two insulin-like peptides differentially regulate malaria parasite infection in the mosquito through effects on intermediary metabolism

Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum

Functional dissection of proliferating-cell nuclear antigens (1 and 2) in human malarial parasite Plasmodium falciparum: possible involvement in DNA replication and DNA damage response

Plasmodium falciparum mitochondria import tRNAs along with an active phenylalanyl-tRNA synthetase

From crystal to compound: structure-based antimalarial drug discovery

Membrane transport in the malaria parasite and its host erythrocyte

Specific phosphorylation of the Pf Rh2b invasion ligand of Plasmodium falciparum

Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite Plasmodium falciparum

The antioxidative effect of de novo generated vitamin B 6 in Plasmodium falciparum validated by protein interference

Structural basis for the efficient phosphorylation of AZT-MP (3′-azido-3′-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase

Comparison of the cellular and biochemical properties of Plasmodium falciparum choline and ethanolamine kinases

A comprehensive model of purine uptake by the malaria parasite Plasmodium falciparum : identification of four purine transport activities in intraerythrocytic parasites

Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum

Evaluation of pH during cytostomal endocytosis and vacuolar catabolism of haemoglobin in Plasmodium falciparum

Selective permeabilization of the host cell membrane of Plasmodium falciparum -infected red blood cells with streptolysin O and equinatoxin II

The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization

Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum , a key enzyme in fatty acid biosynthesis

Identification, molecular cloning and functional characterization of an octaprenyl pyrophosphate synthase in intra-erythrocytic stages of Plasmodium falciparum

Localization of ferrochelatase in Plasmodium falciparum

‘FAS’t inhibition of malaria

Slow-tight-binding inhibition of enoyl-acyl carrier protein reductase from Plasmodium falciparum by triclosan

Heparan sulphate identified on human erythrocytes: a Plasmodium falciparum receptor

Copper pathways in Plasmodium falciparum infected erythrocytes indicate an efflux role for the copper P-ATPase

Characterization of the lipid-binding domain of the Plasmodium falciparum CTP:phosphocholine cytidylyltransferase through synthetic-peptide studies

The role of two novel regulatory sites in the activation of the cGMP-dependent protein kinase from Plasmodium falciparum

The cyclic dipeptide CI-4 [cyclo-(l-Arg-d-Pro)] inhibits family 18 chitinases by structural mimicry of a reaction intermediate

Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials

Email alerts

CONNECT

EXPLORE

Email alerts

CONNECT

EXPLORE

This Feature Is Available To Subscribers Only