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1-29 of 29
Keywords: Pseudomonas aeruginosa
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Articles
Journal:
Biochemical Journal
Biochem J (2025) 482 (11): 621–637.
Published: 23 May 2025
...Piyali Saha; Samir Kumar Mukherjee; Sk Tofajjen Hossain The survival and increasing antimicrobial resistance of various bacteria, including clinically relevant opportunistic pathogen, Pseudomonas aeruginosa , largely depends on their biofilm architectural strength that makes a challenge...
Includes: Supplementary data
Articles
Specialized killing across the domains of life by the type VI secretion systems of Pseudomonas aeruginosa
Open Access
Journal:
Biochemical Journal
Biochem J (2025) 482 (01): 1–15.
Published: 08 January 2025
...Jake Colautti; Steven D. Kelly; John C. Whitney Type VI secretion systems (T6SSs) are widespread bacterial protein secretion machines that inject toxic effector proteins into nearby cells, thus facilitating both bacterial competition and virulence. Pseudomonas aeruginosa encodes three...
Articles
Outer membrane translocation of pyocins via the copper regulated TonB-dependent transporter CrtA
Open Access
Journal:
Biochemical Journal
Biochem J (2023) 480 (14): 1035–1049.
Published: 17 July 2023
...Jiraphan Premsuriya; Khedidja Mosbahi; Iva Atanaskovic; Colin Kleanthous; Daniel Walker Pseudomonas aeruginosa is a common cause of serious hospital-acquired infections, the leading proven cause of mortality in people with cystic fibrosis and is associated with high levels of antimicrobial...
Includes: Supplementary data
Articles
Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity
Open AccessDaniel M. Foulkes, Keri McLean, Marta Sloniecka, Sophie Rustidge, Dominic P. Byrne, Atikah S. Haneef, Craig Winstanley, Neil Berry, David G. Fernig, Stephen B. Kaye
Journal:
Biochemical Journal
Biochem J (2022) 479 (24): 2511–2527.
Published: 22 December 2022
...Daniel M. Foulkes; Keri McLean; Marta Sloniecka; Sophie Rustidge; Dominic P. Byrne; Atikah S. Haneef; Craig Winstanley; Neil Berry; David G. Fernig; Stephen B. Kaye The opportunistic pathogen Pseudomonas aeruginosa is one of leading causes of disability and mortality worldwide and the world health...
Articles
Daniel M. Foulkes, Keri McLean, Yalin Zheng, Joscelyn Sarsby, Atikah S. Haneef, David G. Fernig, Craig Winstanley, Neil Berry, Stephen B. Kaye
Journal:
Biochemical Journal
Biochem J (2021) 478 (3): 647–668.
Published: 12 February 2021
...Daniel M. Foulkes; Keri McLean; Yalin Zheng; Joscelyn Sarsby; Atikah S. Haneef; David G. Fernig; Craig Winstanley; Neil Berry; Stephen B. Kaye Pseudomonas aeruginosa has recently been highlighted by the World Health Organisation (WHO) as a major threat with high priority for the development of new...
Includes: Supplementary data
Articles
A phosphatidic acid-binding protein is important for lipid homeostasis and adaptation to anaerobic biofilm conditions in Pseudomonas aeruginosa
Available to PurchaseMaike K. Groenewold, Marco Massmig, Stefanie Hebecker, Linna Danne, Zofia Magnowska, Manfred Nimtz, Franz Narberhaus, Dieter Jahn, Dirk W. Heinz, Lothar Jänsch, Jürgen Moser
Journal:
Biochemical Journal
Biochem J (2018) 475 (11): 1885–1907.
Published: 06 June 2018
...Maike K. Groenewold; Marco Massmig; Stefanie Hebecker; Linna Danne; Zofia Magnowska; Manfred Nimtz; Franz Narberhaus; Dieter Jahn; Dirk W. Heinz; Lothar Jänsch; Jürgen Moser A quantitative Pseudomonas aeruginosa proteomics approach revealed increased abundance of the so-far uncharacterized protein...
Includes: Supplementary data
Articles
Mechanistic insights into the allosteric regulation of Pseudomonas aeruginosa aspartate kinase
Available to PurchaseChang-Cheng Li, Mei-Jia Yang, Li Liu, Tao Li, Cui-Ting Peng, Li-Hui He, Ying-Jie Song, Yi-Bo Zhu, Ya-Lin Shen, Jing Yang, Ning-Lin Zhao, Chang Zhao, Qiao-Xia Zhou, Hong Li, Mei Kang, Ai-Ping Tong, Hong Tang, Rui Bao
Journal:
Biochemical Journal
Biochem J (2018) 475 (6): 1107–1119.
Published: 20 March 2018
... step of the aspartate family amino acid biosynthesis. Owing to various structural organizations, AKs from different species show tremendous diversity and complex allosteric controls. We report the crystal structure of AK from Pseudomonas aeruginosa (PaAK), a typical α2β2 hetero-tetrameric enzyme...
Includes: Supplementary data
Articles
Laura C. McCaughey, Inokentijs Josts, Rhys Grinter, Paul White, Olwyn Byron, Nicholas P. Tucker, Jacqueline M. Matthews, Colin Kleanthous, Cynthia B. Whitchurch, Daniel Walker
Journal:
Biochemical Journal
Biochem J (2016) 473 (15): 2345–2358.
Published: 28 July 2016
...Laura C. McCaughey; Inokentijs Josts; Rhys Grinter; Paul White; Olwyn Byron; Nicholas P. Tucker; Jacqueline M. Matthews; Colin Kleanthous; Cynthia B. Whitchurch; Daniel Walker Increasing rates of antibiotic resistance among Gram-negative pathogens such as Pseudomonas aeruginosa means alternative...
Includes: Supplementary data
Articles
Identification of novel members of the bacterial azoreductase family in Pseudomonas aeruginosa
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2016) 473 (5): 549–558.
Published: 24 February 2016
... suggested to have NAD(P)H quinone oxidoreductase (NQO) activity which leads to a proposed role in plant pathogenesis. Azoreductases have also been suggested to play a role in the mammalian pathogenesis of Pseudomonas aeruginosa. In view of the importance of P. aeruginosa as a pathogen, we therefore...
Includes: Supplementary data
Articles
Mechanisms of biofilm inhibition and degradation by antimicrobial peptides
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2015) 468 (2): 259–270.
Published: 22 May 2015
... of newly designed peptides that share the same amino acid composition, but differ in their sequences, and hence their biophysical properties and biological function. We used Pseudomonas aeruginosa , an opportunistic Gram-negative bacterium, which is a leading cause of severe pulmonary infections...
Includes: Supplementary data
Articles
TNF induces the expression of the sialyltransferase ST3Gal IV in human bronchial mucosa via MSK1/2 protein kinases and increases FliD/sialyl-Lewis x -mediated adhesion of Pseudomonas aeruginosa
Available to PurchaseFlorent Colomb, Olivier Vidal, Marie Bobowski, Marie-Ange Krzewinski-Recchi, Anne Harduin-Lepers, Eric Mensier, Sophie Jaillard, Jean-Jacques Lafitte, Philippe Delannoy, Sophie Groux-Degroote
Journal:
Biochemical Journal
Biochem J (2014) 457 (1): 79–87.
Published: 10 December 2013
... that the TNF-induced sLe x expression increases the adhesion of the Pseudomonas aeruginosa PAO1 and PAK strains to lung epithelial cells in a FliD-dependent manner. These results suggest that ERK and p38 MAPK, and the downstream kinase MSK1/2, should be considered as potential targets to hamper inflammation...
Articles
Structure and activity of the Pseudomonas aeruginosa hotdog-fold thioesterases PA5202 and PA2801
Available to PurchaseClaudio F. Gonzalez, Anatoli Tchigvintsev, Greg Brown, Robert Flick, Elena Evdokimova, Xiaohui Xu, Jerzy Osipiuk, Marianne E. Cuff, Susan Lynch, Andrzej Joachimiak, Alexei Savchenko, Alexander F. Yakunin
Journal:
Biochemical Journal
Biochem J (2012) 444 (3): 445–455.
Published: 29 May 2012
... and eukaryotes. Many of these proteins exhibit thioesterase activity against fatty acyl-CoAs and play important roles in lipid metabolism, cellular signalling and degradation of xenobiotics. The genome of the opportunistic pathogen Pseudomonas aeruginosa contains over 20 genes encoding predicted hotdog-fold...
Includes: Supplementary data
Articles
Novel NADPH–cysteine covalent adduct found in the active site of an aldehyde dehydrogenase
Available to PurchaseÁngel G. Díaz-Sánchez, Lilian González-Segura, Enrique Rudiño-Piñera, Alfonso Lira-Rocha, Alfredo Torres-Larios, Rosario A. Muñoz-Clares
Journal:
Biochemical Journal
Biochem J (2011) 439 (3): 443–455.
Published: 13 October 2011
...Ángel G. Díaz-Sánchez; Lilian González-Segura; Enrique Rudiño-Piñera; Alfonso Lira-Rocha; Alfredo Torres-Larios; Rosario A. Muñoz-Clares PaBADH ( Pseudomonas aeruginosa betaine aldehyde dehydrogenase) catalyses the irreversible NAD(P) + -dependent oxidation of betaine aldehyde to its corresponding...
Includes: Multimedia, Supplementary data
Articles
Observation of fast release of NO from ferrous d 1 haem allows formulation of a unified reaction mechanism for cytochrome cd 1 nitrite reductases
Available to PurchaseSerena Rinaldo, Katharine A. Sam, Nicoletta Castiglione, Valentina Stelitano, Alessandro Arcovito, Maurizio Brunori, James W. A. Allen, Stuart J. Ferguson, Francesca Cutruzzolà
Journal:
Biochemical Journal
Biochem J (2011) 435 (1): 217–225.
Published: 15 March 2011
... nitric oxide nitrite nitrite reductase Pseudomonas aeruginosa Paracoccus pantotrophus Denitrification is an anaerobic respiratory process, found widely in both autotrophic and heterotrophic micro-organisms [ 1 ], in which oxidized nitrogen compounds, such as nitrate and nitrite, are used...
Includes: Supplementary data
Articles
Promiscuous partnering and independent activity of MexB, the multidrug transporter protein from Pseudomonas aeruginosa
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2010) 430 (2): 355–364.
Published: 13 August 2010
...Alexander Welch; Chidiebere U. Awah; Shiheng Jing; Hendrik W. van Veen; Henrietta Venter The MexAB–OprM drug efflux pump is central to multidrug resistance of Pseudomonas aeruginosa . The ability of the tripartite protein to confer drug resistance on the pathogen is crucially dependent...
Articles
Activation of human pro-urokinase by unrelated proteases secreted by Pseudomonas aeruginosa
Available to PurchaseNathalie Beaufort, Paulina Seweryn, Sophie de Bentzmann, Aihua Tang, Josef Kellermann, Nicolai Grebenchtchikov, Manfred Schmitt, Christian P. Sommerhoff, Dominique Pidard, Viktor Magdolen
Journal:
Biochemical Journal
Biochem J (2010) 428 (3): 473–482.
Published: 27 May 2010
...Nathalie Beaufort; Paulina Seweryn; Sophie de Bentzmann; Aihua Tang; Josef Kellermann; Nicolai Grebenchtchikov; Manfred Schmitt; Christian P. Sommerhoff; Dominique Pidard; Viktor Magdolen Pathogenic bacteria, including Pseudomonas aeruginosa , interact with and engage the host plasminogen (Plg...
Articles
Electrostatic interactions play a minor role in the binding of ExoS to 14-3-3 proteins
Available to PurchaseLubna Yasmin, Jeffrey L. Veesenmeyer, Maureen H. Diaz, Matthew S. Francis, Christian Ottmann, Ruth H. Palmer, Alan R. Hauser, Bengt Hallberg
Journal:
Biochemical Journal
Biochem J (2010) 427 (2): 217–224.
Published: 29 March 2010
...-cycle regulation, apoptosis, stress responses, cell metabolism and malignant transformation. One example of a phosphorylation-independent interaction is the binding of 14-3-3 to ExoS (exoenzyme S), a bacterial ADP-ribosyltransferase toxin of Pseudomonas aeruginosa . In the present study, we have...
Includes: Supplementary data
Articles
Paraoxonase 2 is down-regulated by the Pseudomonas aeruginosa quorumsensing signal N-(3-oxododecanoyl)-L-homoserine lactone and attenuates oxidative stress induced by pyocyanin
Available to PurchaseSven Horke, Ines Witte, Sebastian Altenhöfer, Petra Wilgenbus, Marion Goldeck, Ulrich Förstermann, Junhui Xiao, Gerald L. Kramer, Donovan C. Haines, Puneet K. Chowdhary, Robert W. Haley, John F. Teiber
Journal:
Biochemical Journal
Biochem J (2010) 426 (1): 73–83.
Published: 27 January 2010
...Sven Horke; Ines Witte; Sebastian Altenhöfer; Petra Wilgenbus; Marion Goldeck; Ulrich Förstermann; Junhui Xiao; Gerald L. Kramer; Donovan C. Haines; Puneet K. Chowdhary; Robert W. Haley; John F. Teiber Two virulence factors produced by Pseudomonas aeruginosa are pyocyanin and N -(3-oxododecanoyl...
Articles
Structural basis for mannose recognition by a lectin from opportunistic bacteria Burkholderia cenocepacia
Available to PurchaseEmilie Lameignere, Lenka Malinovská, Margita Sláviková, Eric Duchaud, Edward P. Mitchell, Annabelle Varrot, Ondrej Šedo, Anne Imberty, Michaela Wimmerová
Journal:
Biochemical Journal
Biochem J (2008) 411 (2): 307–318.
Published: 27 March 2008
...Emilie Lameignere; Lenka Malinovská; Margita Sláviková; Eric Duchaud; Edward P. Mitchell; Annabelle Varrot; Ondrej Šedo; Anne Imberty; Michaela Wimmerová Chronic colonization of the lungs by opportunist bacteria such as Pseudomonas aeruginosa and members of the Bcc ( Burkholderia cepacia complex...
Includes: Supplementary data
Articles
Pseudomonas aeruginosa and sPLA 2 IB stimulate ABCA1-mediated phospholipid efflux via ERK-activation of PPARα–RXR
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2007) 403 (3): 409–420.
Published: 12 April 2007
...Marianna Agassandian; Olga L. Miakotina; Matthew Andrews; Satya N. Mathur; Rama K. Mallampalli Bacterial infection triggers an acute inflammatory response that might alter phospholipid metabolism. We have investigated the acute-phase response of murine lung epithelia to Pseudomonas aeruginosa...
Articles
Functional characterization of the dimerization domain of the ferric uptake regulator (Fur) of Pseudomonas aeruginosa
Available to PurchaseErdeni Bai, Federico I. Rosell, Bao Lige, Marcia R. Mauk, Barbara Lelj-Garolla, Geoffrey R. Moore, A. Grant Mauk
Journal:
Biochemical Journal
Biochem J (2006) 400 (3): 385–392.
Published: 28 November 2006
...Erdeni Bai; Federico I. Rosell; Bao Lige; Marcia R. Mauk; Barbara Lelj-Garolla; Geoffrey R. Moore; A. Grant Mauk The functional properties of the recombinant C-terminal dimerization domain of the Pseudomonas aeruginosa Fur (ferric uptake regulator) protein expressed in and purified from Escherichia...
Articles
Structural basis for the interaction between human milk oligosaccharides and the bacterial lectin PA-IIL of Pseudomonas aeruginosa
Available to PurchaseStéphanie Perret, Charles Sabin, Claire Dumon, Martina Pokorná, Catherine Gautier, Oxana Galanina, Shahov Ilia, Nicolai Bovin, Magali Nicaise, Michel Desmadril, Nechama Gilboa-Garber, Michaela Wimmerov´, Edward P. Mitchell, Anne Imberty
Journal:
Biochemical Journal
Biochem J (2005) 389 (2): 325–332.
Published: 05 July 2005
.... In the present study, we demonstrate the specific blocking of PA-IIL, a fucose-binding lectin of the human pathogen Pseudomonas aeruginosa , by milk oligosaccharides. Two fucosylated epitopes, Lewis a and 3-fucosyl-lactose (Lewis x glucose analogue) bind to the lectin with dissociation constants of 2.2×10 −7 M...
Articles
Pseudomonas aeruginosa MutL protein functions in Escherichia coli
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2005) 388 (3): 879–887.
Published: 07 June 2005
...) methylation. Although Pseudomonas aeruginosa does not have the corresponding E. coli MutH and Dam homologues, and consequently the MMRS seems to work differently, we show that the mutL gene from P. aeruginosa is capable of complementing a MutL-deficient strain of E. coli . MutL from P. aeruginosa has...
Articles
Structure–function analysis of water-soluble inhibitors of the catalytic domain of exotoxin A from Pseudomonas aeruginosa
Available to PurchaseSusan P. YATES, Patricia L. TAYLOR, René JØRGENSEN, Dana FERRARIS, Jie ZHANG, Gregers R. ANDERSEN, A. Rod MERRILL
Journal:
Biochemical Journal
Biochem J (2005) 385 (3): 667–675.
Published: 24 January 2005
...Susan P. YATES; Patricia L. TAYLOR; René JØRGENSEN; Dana FERRARIS; Jie ZHANG; Gregers R. ANDERSEN; A. Rod MERRILL The mono-ADPRT (mono-ADP-ribosyltransferase), Pseudomonas aeruginosa ETA (exotoxin A), catalyses the transfer of ADP-ribose from NAD + to its protein substrate. A series of water...
Articles
Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase
Available to PurchaseIsaac M. WESTWOOD, Simon J. HOLTON, Fernando RODRIGUES-LIMA, Jean-Marie DUPRET, Sanjib BHAKTA, Martin E. M. NOBLE, Edith SIM
Journal:
Biochemical Journal
Biochem J (2005) 385 (2): 605–612.
Published: 07 January 2005
...Isaac M. WESTWOOD; Simon J. HOLTON; Fernando RODRIGUES-LIMA; Jean-Marie DUPRET; Sanjib BHAKTA; Martin E. M. NOBLE; Edith SIM The gene for NAT (arylamine N-acetyltransferase) from Pseudomonas aeruginosa ( panat ) has been cloned from genomic DNA, and the gene product (PANAT) expressed as an N...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2003) 374 (2): 413–421.
Published: 01 September 2003
.... Only recently PHA MCL synthases from Pseudomonas oleovorans and Pseudomonas aeruginosa were purified and in vitro activity was achieved. A threading model of the P. aeruginosa PHA MCL synthase PhaC1 was developed based on the homology to the epoxide hydrolase (1ek1) from mouse which belongs to the α/β...
Articles
Exoenzyme S shows selective ADP-ribosylation and GTPase-activating protein (GAP) activities towards small GTPases in vivo
Available to PurchaseMaria L. HENRIKSSON, Charlotta SUNDIN, Anna L. JANSSON, Åke FORSBERG, Ruth H. PALMER, Bengt HALLBERG
Journal:
Biochemical Journal
Biochem J (2002) 367 (3): 617–628.
Published: 01 November 2002
...Maria L. HENRIKSSON; Charlotta SUNDIN; Anna L. JANSSON; Åke FORSBERG; Ruth H. PALMER; Bengt HALLBERG Intracellular targeting of the Pseudomonas aeruginosa toxins exoenzyme S (ExoS) and exoenzyme T (ExoT) initially results in disruption of the actin microfilament structure of eukaryotic cells. ExoS...
Articles
Activation of bacterial ceramidase by anionic glycerophospholipids: possible involvement in ceramide hydrolysis on atopic skin by Pseudomonas ceramidase
Available to PurchaseKatsuhiro KITA, Noriyuki SUEYOSHI, Nozomu OKINO, Masanori INAGAKI, Hideharu ISHIDA, Makoto KISO, Shuhei IMAYAMA, Takashi NAKAMURA, Makoto ITO
Journal:
Biochemical Journal
Biochem J (2002) 362 (3): 619–626.
Published: 08 March 2002
...Katsuhiro KITA; Noriyuki SUEYOSHI; Nozomu OKINO; Masanori INAGAKI; Hideharu ISHIDA; Makoto KISO; Shuhei IMAYAMA; Takashi NAKAMURA; Makoto ITO We have reported previously that the ceramidase from Pseudomonas aeruginosa AN17 isolated from a patient with atopic dermatitis requires detergents...
Articles
Ras effector pathway activation by epidermal growth factor is inhibited in vivo by exoenzyme S ADP-ribosylation of Ras
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2000) 347 (1): 217–222.
Published: 27 March 2000
...Maria L HENRIKSSON; Roland ROSQVIST; Maxim TELEPNEV; Hans WOLF-WATZ; Bengt HALLBERG We have examined the functional consequences of ADP-ribosyltransferase modification of Ras by the exoenzyme S (ExoS) protein of Pseudomonas aeruginosa . ExoS has been shown previously to ADP-ribosylate a number...