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Keywords: RGD motif
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Articles

Disruption of integrin–fibronectin complexes by allosteric but not ligand-mimetic inhibitors

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A. Paul Mould, Susan E. Craig, Sarah K. Byron, Martin J. Humphries, Thomas A. Jowitt
Journal: Biochemical Journal
Biochem J (2014) 464 (3): 301–313.
https://doi.org/10.1042/BJ20141047
Published: 05 December 2014
...+ -supported ligand binding [ 23 – 26 ]. Mn 2+ binding promotes the formation of the open form of the headpiece, whereas Ca 2+ favours the closed headpiece [ 13 , 20 ]. allostery antagonist fibronectin integrin RGD motif therapeutics Integrins are a large family of α,β heterodimeric...
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Includes: Supplementary data
Articles

Mapping the ligand-binding pocket of integrin α5β1 using a gain-of-function approach

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A. Paul Mould, Ewa J. Koper, Adam Byron, Grit Zahn, Martin J. Humphries
Journal: Biochemical Journal
Biochem J (2009) 424 (2): 179–189.
https://doi.org/10.1042/BJ20090992
Published: 11 November 2009
... integrins do bind zebrafish fibronectin-1, and mutagenesis of residues on the upper surface and side of the zebrafish α5 subunit β-propeller domain shows that these residues are important for the recognition of the Arg-Gly-Asp (RGD) motif and the synergy sequence [Pro-His-Ser-Arg-Asn (PHSRN)] in fibronectin...
View article titled, Mapping the ligand-binding pocket of integrin α5β1 using a gain-of-function approach
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Includes: Supplementary data