... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bacteriophages CRISPR protein structure RNA-binding proteins Type I systems, subtypes I-A through I-G, are characterised by the presence of the signature gene cas3 ( Figure 2A ) [ 7 ]. Type I...

... preferred amino acid sequences resulting in proteolysis, but some also use exosites to select and cleave important proteins efficaciously. Such exosites have been found in a few caspases, notably caspase-7 that has a lysine patch (K 38 KKK) that binds RNA, which acts as a bridge to RNA-binding proteins...

... that the localization of fibrillarin and its association with RNA binding proteins is regulated by this phase transition. Phenylalanine-to-serine substitutions of the phenylalanine:glycine repeats in the fibrillarin LC domain impede its phase transition into liquid-like droplets, as well as the hydrogel-like state...

...Jana Alexandrova; David Piñeiro; Rebekah Jukes-Jones; Ryan Mordue; Mark Stoneley; Anne E. Willis NF-κB repressing factor (NKRF) was recently identified as an RNA binding protein that together with its associated proteins, the 5′–3′ exonuclease XRN2 and the helicase DHX15, is required to process...

...Kaiyue Qian; Mengyu Li; Junchao Wang; Min Zhang; Mingzhu Wang RNA-binding protein RBM38 was reported to bind the mRNA of several p53-related genes through its RRM domain and to up-regulate or down-regulate protein translation by increasing mRNA stability or recruitment of other effector proteins...

... chromatin epigenetics gene expression and regulation large intervening noncoding RNA RNA-binding proteins DNA, RNA, and proteins play critical roles in living cells, but RNA is uniquely able to both carry genetic information in the form of nucleotide sequence and also perform biochemical...

... of the Biochemical Society 2018 colorectal cancer IMP1 KRAS RNA-binding proteins The insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), also known as IMP1 or CRD-BP (coding region determinant-binding protein), belongs to a small conserved family of RNA-binding proteins, which also...

... and independent complexes with two identical proteins, integrator complex subunit 3 (INTS3) and C9ORF80. We and other groups have demonstrated that hNABP1 and 2 are single-stranded (ss) DNA- and RNA-binding proteins, and function in DNA repair; however, the function of INTS3 and C9OFR80 remains elusive...

...-transcriptional regulation of TPD52 family genes. An RNA immunoprecipitation (RIP) assay showed the potential binding ability of TPD52 family mRNAs to several RNA-binding proteins, and an RNA degradation assay revealed that TPD52 is subject to more prominent post-transcriptional regulation than are TPD53...

...Alice Ford Harrison; James Shorter Approximately 70 human RNA-binding proteins (RBPs) contain a prion-like domain (PrLD). PrLDs are low-complexity domains that possess a similar amino acid composition to prion domains in yeast, which enable several proteins, including Sup35 and Rnq1, to form...

... known that several diseases are a direct and indirect consequence of aberrant splicing events in humans. In addition to the conventional mode of alternative splicing regulation by ‘ cis ’ RNA-binding sites and ‘ trans’ RNA-binding proteins, recent literature provides enormous evidence for epigenetic...

...Michael Norman; Caroline Rivers; Youn-Bok Lee; Jalilah Idris; James Uney RNA-binding proteins play a central role in cellular metabolism by orchestrating the complex interactions of coding, structural and regulatory RNA species. The SAFB (scaffold attachment factor B) proteins (SAFB1, SAFB2...

.... It contains the bulk of pre-mRNA in association with the abundant group of nuclear RNA-binding proteins : the so-called heterogeneous nuclear (hn) ribonucleo- protein (RNP) species [3]. The interaction of hnRNP proteins with pre-mRNA is currently thought to be sequence- and transcript-specific, and to involve...

.... Key words: actin, cytoskeleton, mRNP, RNA-binding proteins. complex (p36 # p11 # ) together with p11, a protein belonging to the S-100 multigene family. Binding to p11 involves the N-terminal domain of annexin II, which also contains phosphorylation sites for pp60v-src and protein kinase C [15 17...

... for translation in the cytoplasm [1 7]. These RNA-binding proteins belong to several different multigene families. Among them, Y-box proteins have emerged recently as an important family of multifunctional proteins. They are involved in regulation of transcription of a number of genes in several systems [8...