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Keywords: Rab GTPases
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Articles

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR B GTPase domain

Asad U. Malik, Athanasios Karapetsas, Raja S. Nirujogi, Deep Chatterjee, Toan K. Phung, Melanie Wightman, Robert Gourlay, Nick Morrice, Sebastian Mathea, Stefan Knapp, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2022) 479 (18): 1941–1965.
https://doi.org/10.1042/BCJ20220308
Published: 23 September 2022
... Society under a transformative agreement with JISC. GTPases leucine rich repeat kinase protein kinase C Rab GTPases The Leucine Rich Repeat Protein Kinase-1 (LRRK1) and its paralog LRRK2 are large multidomain protein kinases possessing ANK, LRR, ROC-COR A -COR B containing ROCO GTPase...
View articletitled, PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR B GTPase domain
Open the PDF for PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR B GTPase domain in another window
Articles

Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites

Raja S. Nirujogi, Francesca Tonelli, Matthew Taylor, Pawel Lis, Alexander Zimprich, Esther Sammler, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2021) 478 (2): 299–326.
https://doi.org/10.1042/BCJ20200930
Published: 22 January 2021
...Raja S. Nirujogi; Francesca Tonelli; Matthew Taylor; Pawel Lis; Alexander Zimprich; Esther Sammler; Dario R. Alessi Mutations that increase the protein kinase activity of LRRK2 are one of the most common causes of familial Parkinson's disease. LRRK2 phosphorylates a subset of Rab GTPases within...
View articletitled, Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites
Open the PDF for Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites in another window
Includes: Supplementary data
Articles

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase

In Collection
Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019
Pawel Lis, Sophie Burel, Martin Steger, Matthias Mann, Fiona Brown, Federico Diez, Francesca Tonelli, Janice L. Holton, Philip Winglok Ho, Shu-Leong Ho, Meng-Yun Chou, Nicole K. Polinski, Terina N. Martinez, Paul Davies, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2018) 475 (1): 1–22.
https://doi.org/10.1042/BCJ20170802
Published: 02 January 2018
... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . antibodies leucine-rich repeat kinase Parkinson's disease protein kinase Rab GTPases Rab10 Littermate-matched wild-type and homozygous mutant mouse...
View articletitled, Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase
Open the PDF for Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase in another window
Includes: Supplementary data