1-14 of 14
Keywords: RhoA
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Biochem J (2023) 480 (14): 1109–1127.
Published: 19 July 2023
...Lorna O'Donoghue; Shane P. Comer; Dishon W. Hiebner; Ingmar Schoen; Alex von Kriegsheim; Albert Smolenski RhoGAP6 is the most highly expressed GTPase-activating protein (GAP) in platelets specific for RhoA. Structurally RhoGAP6 contains a central catalytic GAP domain surrounded by large, disordered...
Articles
Biochem J (2017) 474 (11): 1897–1918.
Published: 19 May 2017
..., guanylyl cyclase-A (GC-A), ANP maintains cardiovascular homeostasis by exerting diuretic, natriuretic, and hypotensive effects mediated, in part, by endothelial cells. Both in vivo and in vitro , ANP enhances endothelial barrier function by reducing RhoA activity and reorganizing the actin cytoskeleton. We...
Includes: Multimedia, Supplementary data
Articles
Articles
Biochem J (2012) 443 (2): 439–450.
Published: 27 March 2012
... or attenuated the neurite outgrowth associated with dynamic remodelling of the actin-based cytoskeleton. We show that γ-enolase-mediated PI3K activation regulates RhoA kinase, a key regulator of actin cytoskeleton organization. Moreover, the inhibition of RhoA downstream effector ROCK (Rho-associated kinase...
Includes: Supplementary data
Articles
Biochem J (2012) 443 (1): 145–151.
Published: 14 March 2012
...Hsiang-Hao Chuang; Chih-Hsuan Yang; Yeou-Guang Tsay; Chih-Yi Hsu; Ling-Ming Tseng; Zee-Fen Chang; Hsiao-Hui Lee ROCK (Rho-associated protein kinase), a downstream effector of RhoA, plays an important role in many cellular processes. Accumulating evidence has shown the involvement of ROCK activation...
Includes: Supplementary data
Articles
Biochem J (2011) 439 (1): 57–65.
Published: 14 September 2011
...Dean P. Staus; Joan M. Taylor; Christopher P. Mack It is clear that RhoA activates the DRF (diaphanous-related formin) mDia2 by disrupting the molecular interaction between the DAD (diaphanous autoregulatory domain) and the DID (diaphanous inhibitory domain). Previous studies indicate that a basic...
Includes: Supplementary data
Articles
Biochem J (2011) 436 (3): 699–708.
Published: 27 May 2011
.... This interaction was involved in a laminin 511/521-to-actin signalling pathway leading to stress fibre formation. This skeletal rearrangement was associated with an activation of the small GTP-binding protein RhoA, which depended on the integrity of the Lu/BCAM laminin 511/521-binding site. It also required a Lu...
Includes: Supplementary data
Articles
Articles
Articles
Biochem J (2002) 367 (1): 57–65.
Published: 01 October 2002
... in vitro the GTPase activity of RhoA, but is inactive towards other Rho family proteins such as Rac1 and Cdc42; it is also specific for RhoA in vivo . The same is true for the full-length protein, which is furthermore able to down-regulate RhoA-dependent stress fibres in Ref-52 rat fibroblasts...
Articles
Articles
Biochem J (2000) 352 (2): 319–325.
Published: 24 November 2000
... homology domain. p114-Rho-GEF interacted specifically with RhoA, in its nucleotide-free and guanosine 5′-[γ-thio]triphosphate-bound states, but not with Rac1 and Cdc42, and efficiently catalysed guanine nucleotide exchange of RhoA. Consistent with these results in vitro was our finding...
Articles
Articles
Biochem J (1999) 337 (2): 185–192.
Published: 08 January 1999
...)-mediated PLD activation, their role in monosodium urate (MSU)-stimulated PLD1 activity in human neutrophils is not clear. The translocation of PKCα, RhoA and Arf from the cytosol to the membranes was monitored. fMLP induced a cytochalasin B (CB)-dependent recruitment of Arf, RhoA and PKCα to neutrophil...