... residues within the SAH region and a preference for arginine over lysine in its C-terminal half. Using circular dichroism (CD) and NMR spectroscopy, combined with small-angle X-ray scattering (SAXS) measurements, we demonstrate that the Drebrin-SAH is helical and monomeric in solution. NMR resonance...

... the Creative Commons Attribution License 4.0 (CC BY) . anti-infective crystal structure DXR DXR inhibitors enzymatic assay fosmidomycin growth inhibition parasite SAXS Toxoplasma gondii Toxoplasma gondii , the causative agent of toxoplasmosis, is an obligate coccidian parasite member...

... spectrophotometer (Shimadzu). ATPase activity binding analysis EccCb1 M tuberculosis ESX-1 modeling SAXS The Mycobacterium tuberculosis ESX-1 (early secretory antigenic target 6 system-1) system is involved in virulence factor secretion into the host cell and helps mycobacterial survival...

... mechanism of cis -auto-inhibition and initial cis -auto-phosphorylation, followed by transient dimerisation to allow trans -auto-phosphorylation for full activation, yielding a monomeric active PAK protein. kinase SAXS structure Correspondence: Jonathan M. Elkins ( [email protected]...

... regulation calmodulin-binding motif crystal structure inositol trisphosphate 3-kinase Ins(1,4,5) P 3 SAXS Interestingly, Ca 2+ /CaM increases IP 3 -3K activity in mammals via protein–protein interactions [ 11 ]. CaM is a relatively small protein (148 residues in vertebrates) that is highly...