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Keywords: SHP2
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Articles
Cancer stem cell phosphatases
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2021) 478 (14): 2899–2920.
Published: 28 July 2021
... by Portland Press Limited on behalf of the Biochemical Society 2021 DUSP6 PP2A PTEN PTP1B SHP2 WIP1 In normal adult tissues, stem cells (SCs) confer the capacity for tissue regeneration and homeostasis [ 1 ]. The self-renewal capacity of SCs, and generation of differentiated cellular...
Articles
Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP
Available to PurchaseYanli Liu, Johnathan Lau, Weiguo Li, Wolfram Tempel, Li Li, Aiping Dong, Ashrut Narula, Su Qin, Jinrong Min
Journal:
Biochemical Journal
Biochem J (2016) 473 (2): 179–187.
Published: 05 January 2016
... the binding capability of PPxY motifs of TXNIP to Itch, whereas this phosphorylation is a prerequisite to the binding activity of TXNIP to SHP2 [SH2 (Src homology 2) domain-containing protein tyrosine phosphatase 2] and their roles in stabilizing the phosphorylation and activation of CSK (c-Src tyrosine...
Includes: Supplementary data
Articles
Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2005) 391 (1): 143–151.
Published: 26 September 2005
... signals through Gab2. Gab1–SHP2 interaction has been shown to mediate ERK (extracellular-signal-regulated kinase) activation by EGF (epidermal growth factor). However, it was unclear whether EGF selectively utilizes Gab1 for signalling to ERK and whether Gab2 is dispensable in cells where Gab1 and Gab2...
