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Keywords: SUFU
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Articles
SUFU promotes GLI activity in a Hedgehog-independent manner in pancreatic cancer
Available to PurchaseBrooke D. Paradise, Vladimir G. Gainullin, Luciana L. Almada, Ashley N. Sigafoos, Sandhya Sen, Renzo E. Vera, Glancis Luzeena Raja Arul, Murat Toruner, David R. Pease, Alina L. Gonzalez, Fatima M. Mentucci, Daniel H. Grasso, Martin E. Fernandez-Zapico
Journal:
Biochemical Journal
Biochem J (2023) 480 (15): 1199–1216.
Published: 02 August 2023
...) signaling pathway, through which the GLI family of transcription factors (TF) is stimulated, is commonly observed in cancer cells. One well-established mechanism of this increased activity is through the inactivation of Suppressor of Fused (SUFU), a negative regulator of the Hh pathway. Relief from negative...
