... increased the AMPK-dependent phosphorylation of the autophagy-regulating kinase ULK1 (unc-51-like autophagy-activating kinase 1) on Ser 555 , but not proposed AMPK-γ3 substrates such as Ser 231 on TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 (TBC1D1) or Ser 212 on acetyl-CoA carboxylase subunit...

...Kanokwan Vichaiwong; Suneet Purohit; Ding An; Taro Toyoda; Niels Jessen; Michael F. Hirshman; Laurie J. Goodyear TBC1D1 (tre-2/USP6, BUB2, cdc16 domain family member 1) is a Rab-GAP (GTPase-activating protein) that is highly expressed in skeletal muscle, but little is known about TBC1D1 regulation...

...Shuai Chen; Jane Murphy; Rachel Toth; David G. Campbell; Nick A. Morrice; Carol Mackintosh AS160 (Akt substrate of 160 kDa) and TBC1D1 are related RabGAPs (Rab GTPase-activating proteins) implicated in regulating the trafficking of GLUT4 (glucose transporter 4) storage vesicles to the cell surface...

... has now discovered two related molecules that could function in this linking role. These proteins, Tbc1d4 (also known as AS160) and now Tbc1d1, as reported in this issue of the Biochemical Journal , have been demonstrated to be Rab GAPs (GTPase-activating proteins) that link upstream to Akt (protein...

... evidence indicates that the phosphorylation of this protein by Akt (protein kinase B) leads to suppression of its GAP activity and results in the elevation of the GTP form of a critical Rab. The present study examines a similar Rab GAP, Tbc1d1, about which very little is known. We found that the Rab...