...David Harrich; Hongping Jin The HIV-1 tat gene encodes a small 86–104 amino acid protein depending on the HIV-1 strain. Tat is essential for HIV-1 replication through interactions with numerous cellular transcription factors. The interaction between Tat and P-TEFb, which is a cellular protein...

...Rameez Raja; Larance Ronsard; Sneh Lata; Shubhendu Trivedi; Akhil C. Banerjea Murine double minute 2 (Mdm2) is known to enhance the transactivation potential of human immunodeficiency virus (HIV-1) Tat protein by causing its ubiquitination. However, the regulation of Mdm2 during HIV-1 infection...

... studies have indicated that during HIV-1 infection, PACT's normal cellular function is compromised and that PACT is unable to activate PKR. Using various reporter systems and in vitro kinase assays, we establish in this report that interactions between PACT, ADAR1 and HIV-1-encoded Tat protein diminish...

...Anna L. Remoli; Giulia Marsili; Edvige Perrotti; Eleonora Gallerani; Ramona Ilari; Filomena Nappi; Aurelio Cafaro; Barbara Ensoli; Riccardo Gavioli; Angela Battistini The Tat protein is the transcriptional activator of HIV-1 gene expression, which is not only essential for viral replication...

..., induced in response to IFN-γ (interferon-γ) in some cells, and constitutively expressed in others. In this issue of the Biochemical Journal , Remoli and colleagues describe the manipulation of the immunoproteasome by the Tat (transcriptional activation) protein of HIV. The authors show that Tat...

...-terminal CF [5(6)-carboxyfluorescein]-labelled CPP, namely hCT (human calcitonin)-derived sequences, Tat(47–57) and penetratin(43–58), was through Fmoc (fluoren-9-ylmethoxycarbonyl) chemistry. Metabolic degradation kinetics of the tested CPP in contact with three cell-cultured epithelial models, MDCK...

... was a highly effective inhibitor of both soluble and parasite-associated gp63. Finally, MRP ED peptides were synthesized together with an N-terminal HIV-1 Tat transduction domain (TD) to obtain cell-permeant peptide constructs. Such peptides retained gp63 inhibitory activity and efficiently entered both...