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1-27 of 27
Keywords: Type 2 diabetes
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Articles
Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator
Open AccessAshley J. Ovens, Yi Sing Gee, Naomi X.Y. Ling, Dingyi Yu, Justin P. Hardee, Jin D. Chung, Kevin R.W. Ngoei, Nicholas J. Waters, Nolan J. Hoffman, John W. Scott, Kim Loh, Katrin Spengler, Regine Heller, Michael W. Parker, Gordon S. Lynch, Fei Huang, Sandra Galic, Bruce E. Kemp, Jonathan B. Baell, Jonathan S. Oakhill, Christopher G. Langendorf
Journal:
Biochemical Journal
Biochem J (2022) 479 (11): 1181–1204.
Published: 08 June 2022
... strategies to treat type 2 diabetes and insulin resistance, with recent genetic and pharmacological studies indicating the α2β2γ1 isoform combination as the heterotrimer complex primarily responsible. With the goal of developing α2β2-specific activators, here we perform structure/function analysis of the 2...
Includes: Supplementary data
Articles
Piyali Majumder, Kaushik Chanda, Debajyoti Das, Brijesh Kumar Singh, Partha Chakrabarti, Nihar Ranjan Jana, Debashis Mukhopadhyay
Journal:
Biochemical Journal
Biochem J (2021) 478 (17): 3297–3317.
Published: 14 September 2021
...Piyali Majumder; Kaushik Chanda; Debajyoti Das; Brijesh Kumar Singh; Partha Chakrabarti; Nihar Ranjan Jana; Debashis Mukhopadhyay Alzheimer's Disease (AD) and Type 2 Diabetes (T2D) share a common hallmark of insulin resistance. Reportedly, two non-canonical Receptor Tyrosine Kinases (RTKs), ALK...
Includes: Supplementary data
Articles
Impact of pesticide exposure on adipose tissue development and function
Available to PurchaseIn Collection
Adipose biology
Robert M. Gutgesell, Evangelia E. Tsakiridis, Shanza Jamshed, Gregory R. Steinberg, Alison C. Holloway
Journal:
Biochemical Journal
Biochem J (2020) 477 (14): 2639–2653.
Published: 29 July 2020
... and metabolic diseases such as type 2 diabetes. In this review, we discuss epidemiological evidence linking pesticide exposure with body mass index (BMI) and the incidence of diabetes. We then review preclinical studies in rodent models which have directly evaluated the effects of different classes...
Articles
The NLRP3 inflammasome regulates adipose tissue metabolism
Available to PurchaseIn Collection
Adipose biology
Journal:
Biochemical Journal
Biochem J (2020) 477 (6): 1089–1107.
Published: 23 March 2020
... Society 2020 adipocytes immunometabolism inflammasome inflammation obesity type 2 diabetes Adipose tissue is a critical energy storage site, where lipids are primarily stored as triglycerides in adipocytes. White adipocytes mainly act as a lipid storage and release site. In a state...
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (4): 763–772.
Published: 20 February 2020
... and the Biochemical Society under a transformative agreement with CAUL. actin alpha-catenin beta-catenin calcium influx insulin secretion type 2 diabetes The proper control of glucose homeostasis relies on the appropriate levels of insulin being secreted from the β-cells in the pancreas so...
Articles
In Collection
Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019
Journal:
Biochemical Journal
Biochem J (2019) 476 (19): 2883–2908.
Published: 11 October 2019
...Cecilia Jönsson; Ana P. Castor Batista; Preben Kjølhede; Peter Strålfors Control of fatty acid storage and release in adipose tissue is fundamental in energy homeostasis and the development of obesity and type 2 diabetes. We here take the whole signalling network into account to identify how...
Includes: Supplementary data
Articles
Adipose depot-specific effects of ileal interposition surgery in UCD-T2D rats: unexpected implications for obesity and diabetes
Available to PurchaseConnie Hung, Casey Bronec, Eleonora Napoli, James Graham, Kimber L. Stanhope, Ilaria Marsilio, Maria Cecilia Giron, Peter J. Havel, Cecilia Giulivi
Journal:
Biochemical Journal
Biochem J (2018) 475 (3): 649–662.
Published: 14 February 2018
...Connie Hung; Casey Bronec; Eleonora Napoli; James Graham; Kimber L. Stanhope; Ilaria Marsilio; Maria Cecilia Giron; Peter J. Havel; Cecilia Giulivi Ileal interposition (IT) surgery delays the onset of diabetes in a rat model of type-2 diabetes (UCD-T2DM). Here, to gain a deeper understanding...
Includes: Supplementary data
Articles
Recombinant human islet amyloid polypeptide forms shorter fibrils and mediates β-cell apoptosis via generation of oxidative stress
Available to PurchaseRicha Dubey, Pooja Minj, Nikita Malik, Devika M. Sardesai, Shruti H. Kulkarni, Jhankar D. Acharya, Neel Sarovar Bhavesh, Shilpy Sharma, Ashutosh Kumar
Journal:
Biochemical Journal
Biochem J (2017) 474 (23): 3915–3934.
Published: 16 November 2017
...Richa Dubey; Pooja Minj; Nikita Malik; Devika M. Sardesai; Shruti H. Kulkarni; Jhankar D. Acharya; Neel Sarovar Bhavesh; Shilpy Sharma; Ashutosh Kumar Protein misfolding and aggregation play an important role in many human diseases including Alzheimer's, Parkinson's and type 2 diabetes mellitus...
Includes: Supplementary data
Articles
Niclosamide blocks glucagon phosphorylation of Ser 552 on β-catenin in primary rat hepatocytes via PKA signalling
Available to PurchaseMd. Kamrul H. Chowdhury, Lindsay E. Wu, James L.J. Coleman, Nicola J. Smith, Margaret J. Morris, Peter R. Shepherd, Greg C. Smith
Journal:
Biochemical Journal
Biochem J (2016) 473 (9): 1247–1255.
Published: 26 April 2016
... glucagon signalling that leads to increased β-catenin activity that can be reversed with the antihelminthic drug niclosamide, which has recently shown promise as a potential treatment of T2D (Type 2 diabetes). This novel finding could be useful in liver cancer treatment, particularly in the context of T2D...
Articles
Palmitate-induced impairment of glucose-stimulated insulin secretion precedes mitochondrial dysfunction in mouse pancreatic islets
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2016) 473 (4): 487–496.
Published: 09 February 2016
... pancreatic β-cells Type 2 diabetes Type 2 diabetes affects over 500 million people worldwide [ 1 ] and it is generally accepted that obesity is a major risk factor in the development of this metabolic disease [ 2 ]. The obese state is characterized by high non-esterified fatty acids (NEFA) levels...
Articles
miRNA let-7 expression is regulated by glucose and TNF-α by a remote upstream promoter
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2015) 472 (2): 147–156.
Published: 13 November 2015
...Mutsumi Katayama; Rasmus J.O. Sjögren; Brendan Egan; Anna Krook miRNAs regulate protein abundance and control diverse aspects of cellular processes and biological functions in metabolic diseases, such as obesity and type 2 diabetes (T2D). Let (lethal)-7 miRNAs specifically targets genes associated...
Articles
Repurposing metformin: an old drug with new tricks in its binding pockets
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2015) 471 (3): 307–322.
Published: 16 October 2015
... the diseases of old age, including type 2 diabetes (T2D), cardiovascular disease (CVD) and cancer. Developing new ways to improve health in the elderly is therefore a top priority for biomedical research. Although our understanding of the molecular basis of these morbidities has advanced rapidly, effective...
Articles
Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity
Available to PurchaseRebecca J. Ford, Morgan D. Fullerton, Stephen L. Pinkosky, Emily A. Day, John W. Scott, Jonathan S. Oakhill, Adam L. Bujak, Brennan K. Smith, Justin D. Crane, Regje M. Blümer, Katarina Marcinko, Bruce E. Kemp, Hertzel C. Gerstein, Gregory R. Steinberg
Journal:
Biochemical Journal
Biochem J (2015) 468 (1): 125–132.
Published: 05 May 2015
... diabetes Non-alcoholic fatty liver disease (NAFLD) is estimated to affect nearly 40% of all adults and more than 80% of those with type 2 diabetes (T2D) [ 1 ]. Elevated rates of liver fatty acid synthesis ( de novo lipogenesis) cause NAFLD in humans [ 2 ] and NAFLD may promote the development...
Articles
Novel insights into pancreatic β-cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cells
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2013) 456 (3): 417–426.
Published: 22 November 2013
... Obesity-related pancreatic β-cell failure contributes to development of Type 2 diabetes. We show that defects in mitochondrial oxidative phosphorylation largely account for fatty-acid-induced impairment of glucose-stimulated insulin secretion, but not for the lipotoxicity-related loss of β-cell viability...
Articles
Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release
Available to PurchasePeter Spégel, Vladimir V. Sharoyko, Isabel Goehring, Anders P. H. Danielsson, Siri Malmgren, Cecilia L. F. Nagorny, Lotta E. Andersson, Thomas Koeck, Geoffrey W. G. Sharp, Susanne G. Straub, Claes B. Wollheim, Hindrik Mulder
Journal:
Biochemical Journal
Biochem J (2013) 450 (3): 595–605.
Published: 28 February 2013
... Biochemical Society 2013 glutathione islets mass spectrometry NADPH ribose 5-phosphate Type 2 diabetes A metabolomics approach allows a deeper understanding of metabolism. The goal of metabolomics is an unbiased and global determination of all metabolites in a biological sample [ 16...
Includes: Supplementary data
Articles
The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a
Available to PurchaseAmy R. Cameron, Katherine Wallace, Lisa Logie, Alan R. Prescott, Terry G. Unterman, Jean Harthill, Graham Rena
Journal:
Biochemical Journal
Biochem J (2012) 443 (1): 57–64.
Published: 14 March 2012
...Amy R. Cameron; Katherine Wallace; Lisa Logie; Alan R. Prescott; Terry G. Unterman; Jean Harthill; Graham Rena Many diseases of aging including AD (Alzheimer's disease) and T2D (Type 2 diabetes) are strongly associated with common risk factors, suggesting that there may be shared aging mechanisms...
Articles
Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells
Available to PurchaseJulien Véret, Nicolas Coant, Evgeny V. Berdyshev, Anastasia Skobeleva, Nicole Therville, Danielle Bailbé, Irina Gorshkova, Viswanathan Natarajan, Bernard Portha, Hervé Le Stunff
Journal:
Biochemical Journal
Biochem J (2011) 438 (1): 177–189.
Published: 27 July 2011
...) was added to lipid extracts which were incubated for 30 min at 210 °C. After cooling, water and 4.2% ammonium molybdate in 4 M HCl/0.045% Malachite Green (1:3, v/v) was added. Samples were incubated at 37 °C for 30 min, and absorbance was measured at 660 nm. Type 2 diabetes mellitus is a disease...
Includes: Supplementary data
Articles
A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking
Available to PurchaseEbru Boslem, Gemma MacIntosh, Amanda M. Preston, Clarissa Bartley, Anna K. Busch, Maria Fuller, D. Ross Laybutt, Peter J. Meikle, Trevor J. Biden
Journal:
Biochemical Journal
Biochem J (2011) 435 (1): 267–276.
Published: 15 March 2011
...Ebru Boslem; Gemma MacIntosh; Amanda M. Preston; Clarissa Bartley; Anna K. Busch; Maria Fuller; D. Ross Laybutt; Peter J. Meikle; Trevor J. Biden Saturated fatty acids promote lipotoxic ER (endoplasmic reticulum) stress in pancreatic β-cells in association with Type 2 diabetes. To address...
Includes: Supplementary data
Articles
NF-κB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance
Available to PurchaseSuman Dasgupta, Sushmita Bhattacharya, Anindita Biswas, Subeer S. Majumdar, Satinath Mukhopadhyay, Sukanta Ray, Samir Bhattacharya
Journal:
Biochemical Journal
Biochem J (2010) 429 (3): 451–462.
Published: 14 July 2010
...Suman Dasgupta; Sushmita Bhattacharya; Anindita Biswas; Subeer S. Majumdar; Satinath Mukhopadhyay; Sukanta Ray; Samir Bhattacharya Fetuin-A, a hepatic secretory protein, has recently been implicated in insulin resistance and Type 2 diabetes. It is an endogenous inhibitor of insulin receptor...
Includes: Supplementary data
Articles
Mechanisms involved in the developmental programming of adulthood disease
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2010) 427 (3): 333–347.
Published: 14 April 2010
... structures and the epigenome, and (ii) how aberrant mitochondrial function can potentially lead to the development of Type 2 diabetes and other features of metabolic syndrome. 1 To whom correspondence should be addressed (email [email protected] ). 22 12 2009 18 2 2010 19 2 2010...
Articles
Brd2 disruption in mice causes severe obesity without Type 2 diabetes
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2010) 425 (1): 71–85.
Published: 14 December 2009
... in Type 2 diabetes. Current searches for relevant genes consume significant effort. We have reported previously a novel double bromodomain protein called Brd2, which is a transcriptional co-activator/co-repressor with SWI/SNF (switch mating type/sucrose non-fermenting)-like functions that regulates...
Includes: Supplementary data
Articles
Pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) deficiency attenuates the long-term negative effects of a high-saturated fat diet
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2009) 423 (2): 243–252.
Published: 25 September 2009
...Byounghoon Hwang; Nam Ho Jeoung; Robert A. Harris The hypothesis that PDHK4 (pyruvate dehydrogenase kinase isoenzyme 4) has potential as a target for the treatment of type 2 diabetes was tested by feeding wild-type and PDHK4 knockout mice a high saturated fat diet that induces hyperglycemia...
Articles
Regulation and function of triacylglycerol lipases in cellular metabolism
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2008) 414 (3): 313–325.
Published: 27 August 2008
... lipase (HSL) obesity skeletal muscle Type 2 diabetes Intracellular lipid pools are in a constant state of flux, with overall lipid content ultimately dependent on the balance between the rates of FA (fatty acid) uptake, esterification, hydrolysis and oxidation [ 1 – 3 ]. FAs are used...
Includes: Multimedia, Supplementary data
Articles
Inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2008) 412 (2): 359–366.
Published: 14 May 2008
...Darya Zibrova; Rolf Grempler; Rüdiger Streicher; Stefan G. Kauschke In Type 2 diabetes, increased glycogenolysis contributes to the hyperglycaemic state, therefore the inhibition of GP (glycogen phosphorylase), a key glycogenolytic enzyme, is one of the possibilities to lower plasma glucose levels...
Articles
Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2008) 409 (1): 199–204.
Published: 11 December 2007
... secretion mitochondrial uncoupling oxidative phosphorylation pancreatic β-cell Type 2 diabetes uncoupling protein-2 (UCP2) Type 2 diabetes is rapidly becoming a global pandemic. Although the development of this metabolic disorder is understood incompletely, it is evident that pancreatic β-cell...
Articles
Stronger control of ATP/ADP by proton leak in pancreatic β-cells than skeletal muscle mitochondria
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2006) 393 (1): 151–159.
Published: 12 December 2005
... be addressed (email [email protected] ). 5 8 2005 26 8 2005 2 9 2005 2 9 2005 The Biochemical Society, London 2006 metabolic control analysis mitochondrial oxidative phosphorylation modular kinetics pancreatic beta cell (β-cell) proton leak type 2 diabetes...
Articles
Pancreatic beta-cell granule peptides form heteromolecular complexes which inhibit islet amyloid polypeptide fibril formation
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2004) 377 (3): 709–716.
Published: 01 February 2004
...Emma T. A. S. JAIKARAN; Melanie R. NILSSON; Anne CLARK Islet amyloid polypeptide (IAPP), or ‘amylin’, is co-stored with insulin in secretory granules of pancreatic islet β-cells. In Type 2 diabetes, IAPP converts into a β-sheet conformation and oligomerizes to form amyloid fibrils and islet...
