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Keywords: Type 2 diabetes
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Adipose biology
Biochem J (2020) 477 (14): 2639–2653.
Published: 29 July 2020
... and metabolic diseases such as type 2 diabetes. In this review, we discuss epidemiological evidence linking pesticide exposure with body mass index (BMI) and the incidence of diabetes. We then review preclinical studies in rodent models which have directly evaluated the effects of different classes...
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Adipose biology
Biochem J (2020) 477 (6): 1089–1107.
Published: 23 March 2020
... are elevated in obese and type 2 diabetic patients and each cytokine could potentially modify insulin resistance and development of type 2 diabetes (T2D) [ 79–83 ]. Figure 1. Upstream activators of the NLRP3 inflammasome in adipose tissue. Priming: Following PRR stimulation, nuclear NF-κB...
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Biochem J (2016) 473 (9): 1247–1255.
Published: 26 April 2016
... glucagon signalling that leads to increased β-catenin activity that can be reversed with the antihelminthic drug niclosamide, which has recently shown promise as a potential treatment of T2D (Type 2 diabetes). This novel finding could be useful in liver cancer treatment, particularly in the context of T2D...
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Biochem J (2015) 472 (2): 147–156.
Published: 13 November 2015
...Mutsumi Katayama; Rasmus J.O. Sjögren; Brendan Egan; Anna Krook miRNAs regulate protein abundance and control diverse aspects of cellular processes and biological functions in metabolic diseases, such as obesity and type 2 diabetes (T2D). Let (lethal)-7 miRNAs specifically targets genes associated...
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Biochem J (2015) 471 (3): 307–322.
Published: 16 October 2015
... the diseases of old age, including type 2 diabetes (T2D), cardiovascular disease (CVD) and cancer. Developing new ways to improve health in the elderly is therefore a top priority for biomedical research. Although our understanding of the molecular basis of these morbidities has advanced rapidly, effective...
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Biochem J (2012) 443 (1): 57–64.
Published: 14 March 2012
...Amy R. Cameron; Katherine Wallace; Lisa Logie; Alan R. Prescott; Terry G. Unterman; Jean Harthill; Graham Rena Many diseases of aging including AD (Alzheimer's disease) and T2D (Type 2 diabetes) are strongly associated with common risk factors, suggesting that there may be shared aging mechanisms...
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Biochem J (2010) 429 (3): 451–462.
Published: 14 July 2010
...Suman Dasgupta; Sushmita Bhattacharya; Anindita Biswas; Subeer S. Majumdar; Satinath Mukhopadhyay; Sukanta Ray; Samir Bhattacharya Fetuin-A, a hepatic secretory protein, has recently been implicated in insulin resistance and Type 2 diabetes. It is an endogenous inhibitor of insulin receptor...
Includes: Supplementary data
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Biochem J (2010) 427 (3): 333–347.
Published: 14 April 2010
... structures and the epigenome, and (ii) how aberrant mitochondrial function can potentially lead to the development of Type 2 diabetes and other features of metabolic syndrome. 1 To whom correspondence should be addressed (email seo10@cam.ac.uk ). 22 12 2009 18 2 2010 19 2 2010...
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Biochem J (2009) 423 (2): 243–252.
Published: 25 September 2009
...Byounghoon Hwang; Nam Ho Jeoung; Robert A. Harris The hypothesis that PDHK4 (pyruvate dehydrogenase kinase isoenzyme 4) has potential as a target for the treatment of type 2 diabetes was tested by feeding wild-type and PDHK4 knockout mice a high saturated fat diet that induces hyperglycemia...
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Biochem J (2008) 414 (3): 313–325.
Published: 27 August 2008
... lipase (HSL) obesity skeletal muscle Type 2 diabetes Intracellular lipid pools are in a constant state of flux, with overall lipid content ultimately dependent on the balance between the rates of FA (fatty acid) uptake, esterification, hydrolysis and oxidation [ 1 – 3 ]. FAs are used...
Includes: Multimedia, Supplementary data
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Biochem J (2006) 393 (1): 151–159.
Published: 12 December 2005
... oxidative phosphorylation modular kinetics pancreatic beta cell (β-cell) proton leak type 2 diabetes The global incidence of type 2 diabetes is rising rapidly as 300 million people, mostly young adults, are projected to be affected by the year 2025 [ 1 ]. Multiple organ sites are involved...
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Biochem J (2004) 377 (3): 709–716.
Published: 01 February 2004
...Emma T. A. S. JAIKARAN; Melanie R. NILSSON; Anne CLARK Islet amyloid polypeptide (IAPP), or ‘amylin’, is co-stored with insulin in secretory granules of pancreatic islet β-cells. In Type 2 diabetes, IAPP converts into a β-sheet conformation and oligomerizes to form amyloid fibrils and islet...