...Yongsheng Huang; Peng Wang; Hua Chen; Yi Ding; Ye-Guang Chen Our results revealed that Myc-interacting zinc-finger protein 1 (MIZ1) enhances Wnt signalling by protecting Dishevelled (Dvl) from Dapper1 (Dpr1)-mediated degradation and promotes cell proliferation. Human embryonic kidney (HEK)293T...

...Wantae Kim; Minseong Kim; Eek-hoon Jho Wnt/β-catenin signalling plays essential roles in embryonic development as well as tissue homoeostasis in adults. Thus abnormal regulation of Wnt/β-catenin signalling is linked to a variety of human diseases, including cancer, osteoporosis and Alzheimer's...

...Mitchell E. Menezes; Aparna Mitra; Lalita A. Shevde; Rajeev S. Samant DKK1 (dickkopf 1 homologue) is a secreted inhibitor of the Wnt signalling pathway and a critical modulator of tumour promotion and the tumour microenvironment. However, mechanisms regulating DKK1 expression are understudied...

...-lipoprotein-receptor-related protein) (Wnt co-receptor) and Sfrp (secreted frizzled-related protein) (Wnt antagonist) expression, which, in turn, may selectively enhance Lrp-independent non-canonical Wnt pathways in chondrocytes. In agreement with these findings, Ihh-induced Nkx3.2 degradation requires Wnt5a...

...Maria V. Barbolina; Rebecca J. Burkhalter; M. Sharon Stack Wnt signalling pathways have been shown to play key roles in both normal development and tumorigenesis. Progression of many human cancers is associated with defined mutations in Wnt pathway components that result in dysregulated β-catenin...

...Hwajin Jung; Suk Kyung Lee; Eek-hoon Jho Mest (mesoderm-specific transcript)/ Peg1 (paternally expressed gene 1) is an imprinted gene that plays important roles in embryo development, although its biochemical role has not been determined. Ectopic expression of Mest/Peg1 inhibited Wnt-mediated...

...Mark W. L. Kennedy; Kenneth R. Kao In Xenopus laevis embryonic development, activation of the Wnt/β-catenin pathway promotes mesoderm cell fate determination via Xnr ( Xenopus nodal-related) expression. We have demonstrated previously that Rel/NF-κB (nuclear factor κB) proteins expressed...

...Craig C. Malbon Wnt signalling remains a hot topic for cell signalling sleuthhounds. The trail of signalling downstream of the seven-transmembrane segment Frizzleds, which bind Wnt ligands, is replete of clues [e.g. LPR5/6 (lipoprotein receptor-related protein 5/6), G-proteins or Dishevelled...

...Alexandra Traister; Wen Shi; Jorge Filmus Glypicans are heparan sulfate proteoglycans that are attached to the cell surface by a GPI (glycosylphosphatidylinositol) anchor. Glypicans regulate the activity of Wnts, Hedgehogs, bone morphogenetic proteins and fibroblast growth factors...

... the gluconeogenic precursors alanine, lactate and glutamine. Expression changes among several members of the Wnt signalling pathway were identified, suggesting an as yet unexplained role in glycogen meta-bolism. In liver, the upregulation of Pfkfb1 and Pfkfb3 expression is consistent with increased glycolysis...

...Sheelagh FRAME; Philip COHEN Identified originally as a regulator of glycogen metabolism, glycogen synthase kinase-3 (GSK3) is now a well-established component of the Wnt signalling pathway, which is essential for setting up the entire body pattern during embryonic development. It may also play...